Dinitolmide

225.16

225.16

204-499-8

AOX68RY4TV

1552

758213

DTXSID6042521

Crystals from dilute alcohol|Yellowish, crystalline solid|Yellowish solid or needles from aqueous ethanol

29242990

134.73000

1.01

Yellowish, crystalline solid. Mp: 177°C. Very slightly soluble in water. Soluble in acetone, acetonitrile, and dimethylformamide. Used as an anti-parasite drug for poultry. Store in a cool, ventilated place, away from acute fire hazards and easily oxidized materials.

1.5406 (rough estimate)

181 °C

366.66°C (rough estimate)

2 °C

1.7400 (estimate)

Slight

0-6°C

6.78X10-8 mm Hg at 25 deg C /Estimated/

Noncombustible Solid

A 1.3 tons batch of off-spec. material had been redried in a rotating double cone vacuum drier heated by steam to around 120-130 deg C for 23 hr. It was left in the drier after heating had been discontinued (though cooling was not applied) and air had been allowed in, to await discharge the next working day. After 2 hr, a violent explosion occurred. Later investigation of the stability of the compound, notably by accelerating rate calorimetry techniques, showed that the excessively long drying t

Henry's Law constant = 3.8X10-14 atm-cu m/mole @ 25 °C /Estimated/

143.7 Ų [M+H]+ [CCS Type: TW, Method: calibrated with polyalanine and drug standards]

Hydroxyl radical reaction rate constant = 2.1X10-12 cu cm/molecule-sec @ 25 °C /Estimated/

No rapid reaction with air No rapid reaction with water

Amides and Imides

DINITOLMIDE reacts as an oxidizing agent. Has been known on at least one occasion to explode destructively. Incompatible with easily oxidized materials. Emits toxic NOx fumes if heated to decomposition.

Noncombustible Solid

UN 1648 3/PG 2

2

22

36

XS4200000

Xn

P264, P270, P280, P301+P312, P302+P352, P321, P330, P332+P313, P362, P501

H302

SRP: The most favorable course of action is to use an alternative chemical product with less inherent propensity for occupational exposure or environmental contamination. Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air quality; potential migration in soil or water; effects on animal, aquatic, and plant life; and conformance with environmental and public health regulations.

Tolerances are established for residues of zoalene (3,5-dinitro-o- toluamide) and its metabolite 3-amino-5-nitro-o-toluamide in food as follows: (a) In edible tissues of chickens: (1) 6 parts per million in uncooked liver and kidney; (2) 3 parts per million in uncooked muscle tissue; (3) 2 parts per million in uncooked fat. (b) In edible tissues of turkeys: 3 parts per million in uncooked muscle tissue and liver.

Not combustible.

|Warning|H302: Harmful if swallowed [Warning Acute toxicity, oral]|P264, P270, P280, P301+P312, P302+P352, P321, P330, P332+P313, P362, and P501

In case of fire in the surroundings, use appropriate extinguishing media.

Skin: Wear appropriate personal protective clothing to prevent skin contact. Eyes: Wear appropriate eye protection to prevent eye contact. Wash skin: The worker should immediately wash the skin when it becomes contaminated. Remove: Work clothing that becomes wet or significantly contaminated should be removed and replaced. Change: Workers whose clothing may have become contaminated should change into uncontaminated clothing before leaving the work premise. (NIOSH, 2016)|Wear appropriate personal protective clothing to prevent skin contact.|Wear appropriate eye protection to prevent eye contact.|(See protection codes)

A 1.3 tons batch of off-spec. material had been redried in a rotating double cone vacuum drier heated by steam to around 120-130 °C for 23 hr. It was left in the drier after heating had been discontinued (though cooling was not applied) and air had been allowed in, to await discharge the next working day. After 2 hr, a violent explosion occurred. Later investigation of the stability of the compound, notably by accelerating rate calorimetry techniques, showed that the excessively long drying time had probably caused the onset of thermal decomposition while heat was still being applied, and that further storage under virtually adiabatic conditions would have led to the steady acceleration of the exothermic decomposition to the point of explosion. At this point, it was estimated that a temperature in excess of 800 °C had been attained in the drier at detonation, when the shock wave would generate a pressure approaching 800 bar. Differential scanning calorimetry techniques had shown exotherms at 273 °C for unheated material, and of 248-259 for material which had been preheated using conditions thought to be present in the drier. The finely powdered amide is also a significant dust explosion hazard, maximum explosion pressures of 10.4 bar and maximum rate of rise above 680 bar/second having been determined.

SRP: The scientific literature for the use of contact lenses in industry is conflicting. The benefit or detrimental effects of wearing contact lenses depend not only upon the substance, but also on factors including the form of the substance, characteristics and duration of the exposure, the uses of other eye protection equipment, and the hygiene of the lenses. However, there may be individual substances whose irritating or corrosive properties are such that the wearing of contact lenses would be harmful to the eye. In those specific cases, contact lenses should not be worn. In any event, the usual eye protection equipment should be worn even when contact lenses are in place.|SRP: Contaminated protective clothing should be segregated in such a manner so that there is no direct personal contact by personnel who handle, dispose, or clean the clothing. Quality assurance to ascertain the completeness of the cleaning procedures should be implemented before the decontaminated protective clothing is returned for reuse by the workers. Contaminated clothing should not be taken home at end of shift, but should remain at employee's place of work for cleaning.|The worker should immediately wash the skin when it becomes contaminated.|Work clothing that becomes wet or significantly contaminated should be removed and replaced.|Workers whose clothing may have become contaminated should change into uncontaminated clothing before leaving the work premises.

Recommended Exposure Limit: 10 Hr Time-Weighted Avg: 5 mg/cu m

Personal protection: particulate filter respirator adapted to the airborne concentration of the substance. Sweep spilled substance into covered containers. If appropriate, moisten first to prevent dusting.

A nuisance-causing concentration of airborne particles can be reached quickly when dispersed.

Use local exhaust or breathing protection.

Protective gloves.

Wear safety goggles.

LD50 Rat oral 600 mg/kg|LD50 Dog iv 75 mg/kg

(VET): Coccidiostat|VET: /Dinitolmide exerts its/ greatest coccidiostatic activity against the asexual stages by arresting parasite development. Efficacy is limited to Eimeria tenell and E. necatrix unless combined with other products.

Agents useful in the treatment or prevention of COCCIDIOSIS in man or animals. (See all compounds classified as Coccidiostats.)

Exposure Routes: inhalation, ingestion, skin and/or eye contact Symptoms: Contact eczema Target Organs: Skin, liver, blood (NIOSH, 2016)

Eye: If this chemical contacts the eyes, immediately wash the eyes with large amounts of water, occasionally lifting the lower and upper lids. Get medical attention immediately. Contact lenses should not be worn when working with this chemical. Skin: If this chemical contacts the skin, immediately wash the contaminated skin with soap and water. If this chemical penetrates the clothing, immediately remove the clothing, wash the skin with soap and water, and get medical attention promptly. Breathing: If a person breathes large amounts of this chemical, move the exposed person to fresh air at once. If breathing has stopped, perform mouth-to-mouth resuscitation. Keep the affected person warm and at rest. Get medical attention as soon as possible. Swallow: If this chemical has been swallowed, get medical attention immediately. (NIOSH, 2016)|(See procedures)

Fresh air, rest.

Rinse and then wash skin with water and soap.

First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.

Basic treatment: Establish a patent airway. Suction if necessary. Watch for signs of respiratory insufficiency and assist ventilations if needed. Administer oxygen by nonrebreather mask at 10 to 15 L/min. Monitor for pulmonary edema and treat if necessary ... . Monitor for shock and treat if necessary ... . Anticipate seizures and treat if necessary ... . For eye contamination, flush eyes immediately with water. Irrigate each eye continuously with normal saline during transport ... . Do not use emetics. For ingestion, rinse mouth and administer 5 ml/kg up to 200 ml of water for dilution if the patient can swallow, has a strong gag reflex, and does not drool ... . Cover skin burns with dry sterile dressings after decontamination ... . /Poison A and B/|Advanced treatment: Consider orotracheal or nasotracheal intubation for airway control in the patient who is unconscious, has severe pulmonary edema, or is in respiratory arrest. Positive pressure ventilation techniques with a bag valve mask device may be beneficial. Monitor cardiac rhythm and treat arrhythmias as necessary ... . Start an IV with D5W /SRP: "To keep open", minimal flow rate/. Use lactated Ringer's if signs of hypovolemia are present. Watch for signs of fluid overload. Consider drug therapy for pulmonary edema ... . For hypotension with signs of hypovolemia, administer fluid cautiously. Watch for signs of fluid overload ... . Treat seizures with diazepam (Valium) ... . Use proparacaine hydrochloride to assist eye irrigation ... . /Poison A and B/

/SIGNS AND SYMPTOMS/ Potential symptom of overexposure by direct contact is eczema.

Coccidot

The substance can be absorbed into the body by ingestion.|inhalation, ingestion, skin and/or eye contact

Contact eczema; In Animals: methemoglobinemia, liver changes

Skin, liver, blood

Zoalene

Harris et al, US 2937204 (1960 to Dow)

Method: AOAC 961.26, Zoalene in Feeds; Procedure: spectrophotometric method; Analyte: zoalene; Matrix: feeds; Detection Level: not reported.[|Method: AOAC 966.26, Zoalene Residues in Animal Tissues; Procedure: spectrophotometric method; Analyte: zoalene; Matrix: animal tissue; Detection Level: not reported.[

Animal Drugs -> FDA Approved Animal Drug Products (Green Book) -> Active Ingredients