ETHYL2-FLUOROPHENYLACETATE
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ETHYL2-FLUOROPHENYLACETATE
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CAS No:
584-74-7
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Formula:
C10H11FO2
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Chemical Name:
ETHYL2-FLUOROPHENYLACETATE
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Synonyms:
ETHYL2-FLUOROPHENYLACETATE;Ethyl2-fluorophenylacetate99%;Ethyl2-(2-fluorophenyl)acetate;2-Fluorophenylaceticacidethylester;2-Fluorophenylaceticacidethylester,Ethyl(2-fluorophenyl)acetate
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CAS No:
Safety Information
36/38
26-36
P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, P501
H315
ETHYL2-FLUOROPHENYLACETATE Use and Manufacturing
At RT, 30 ml of conc. sulfuric acid were added dropwise slowly and carefully to a solution of 2-fluorophenylacetic acid (20 g) in EtOH (300 ml). The mixture was then heated at reflux for 5 hours, put into ice water (400 g) and extracted with MTBE (3×250 ml). The combined organic phases were dried over sodium sulfate and concentrated. This gave 22.7 g of the desired product as a white solid (96%). 1H NMR (300 MHz, CDCl3) delta 7.28-7.23 (m, 2H), 7.12-7.05 (m, 2H), 4.17 (q, J=6 Hz, 2H), 3.66 (s, 2H), 1.25 (t, J=7.2 Hz, 3H).Concentrated sulfuric acid (2 mL) was added slowly to a stirred solution of 2- fluorophenylacetic acid a (10.0 g, 65.0 mmol) in toluene (100 mL) and EtOH (7.6 mL, 130 mmol). The resulting mixture was heated at 100 0C for 1.5 h. It was concentrated in vacuo, diluted with EtOAc (200 mL), washed with 10% K2CO3 until the washes were basic, dried (MgSO4), and concentrated in vacuo to afford 9.9 g (84%) of ester b as a light yellow oil.
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