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Methicillin sodium

Methicillin sodium structure

CAS No:
132-92-3
Formula:
C17H20N2O6S.Na
Chemical Name:
Methicillin sodium
Synonyms:
4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid,6-[(2,6-dimethoxybenzoyl)amino]-3,3-dimethyl-7-oxo-,sodium salt (1:1),(2S,5R,6R)-;4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid,6-(2,6-dimethoxybenzamido)-3,3-dimethyl-7-oxo-,monosodium salt;4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid,6-[(2,6-dimethoxybenzoyl)amino]-3,3-dimethyl-7-oxo-,monosodium salt,[2S-(2α,5α,6β)]-;4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid,6-[(2,6-dimethoxybenzoyl)amino]-3,3-dimethyl-7-oxo-,monosodium salt,(2S,5R,6R)-;Belfacillin;Dimocillin-R-2;Dimocillin sodium;Sodium 6-(2,6-dimethoxybenzamido)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate;Sodium 6-(2′,6′-dimethoxybenzamido)penicillanate;Staphcillin;Sodium (2,6-dimethoxyphenyl)penicillin;Methicillin sodium;Methicillin sodium salt;Sodium methicillin;Celpilline;Sodium dimethoxyphenylpenicillin;Estafcilina;Penysol;Lucopenin;Staficyn;Penaureus;Synticillin;X-1497;SQ 16123;Flabelline;Cinopenil;Meticillin sodium;Celbenin;Meticillin sodium salt;Dimocillin;Azapen;Penistaph;Dimethoxyphenecillin sodium;Celpillina;BRL 1241;3690-70-8
Categories:
Active Pharmaceutical Ingredients > Antibiotics

Description

Methicillin is a β-lactam antibiotic which acts by inhibiting penicillin-binding proteins that are involved in the synthesis of peptidoglycan.

Methicillin(1-) is a penicillinate anion. It is a conjugate base of a methicillin.|One of the PENICILLINS which is resistant to PENICILLINASE but susceptible to a penicillin-binding protein. It is inactivated by gastric acid so administered by injection.

Methicillin sodium Basic Attributes

Molecular Weight：

402.39733

Exact Mass：

402.08600

EC Number：

205-083-9

DSSTox ID：

DTXSID30872398

Characteristics

PSA：

133.30000

Appearance：

white to off-white

Melting Point：

196-197℃

Boiling Point：

640℃

Flash Point：

>110°(230°F)

Water Solubility：

Slightly soluble in acetone. soluble in ethanol or water

Storage Conditions：

2-8°C

Safety Information

hazard class code：

36/37/38-42/43

safety instructions：

26-36

RTECS Number：

XH8950000

Marks：

Precautionary statement(s)：

P261, P264, P271, P272, P280, P285, P302+P352, P304+P340, P304+P341, P305+P351+P338, P312, P321, P332+P313, P333+P313, P337+P313, P342+P311, P362, P363, P403+P233, P405, P501

Hazard Statements：

H315

GHS Classification：

|Danger|H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]|P261, P264, P271, P272, P280, P285, P302+P352, P304+P340, P304+P341, P305+P351+P338, P312, P321, P332+P313, P333+P313, P337+P313, P342+P311, P362, P363, P403+P233, P405, and P501|Aggregated GHS information provided by 39 companies from 2 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Drug Information

MeSH：

Substances that inhibit the growth or reproduction of BACTERIA. (See all compounds classified as Anti-Bacterial Agents.)

MeSH Entry Terms：

Dimethoxyphenyl Penicillin

Methicillin sodium Use and Manufacturing

Uses

antibacterial

Use Classification：

Human Drugs -> FDA Approved Drug Products with Therapeutic Equivalence Evaluations (Orange Book) -> Active Ingredients

Computed Properties

Molecular Weight:379.4
XLogP3:1.9
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:4
Exact Mass:379.09638250
Monoisotopic Mass:379.09638250
Topological Polar Surface Area:133
Heavy Atom Count:26
Formal Charge:-1
Complexity:595
Defined Atom Stereocenter Count:3
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes