2-(Acetylamino)-5-nitrothiazole
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2-(Acetylamino)-5-nitrothiazole
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CAS No:
140-40-9
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Formula:
C5H5N3O3S
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Chemical Name:
2-(Acetylamino)-5-nitrothiazole
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Synonyms:
Acetamide,N-(5-nitro-2-thiazolyl)-;Thiazole,2-acetamido-5-nitro-;N-(5-Nitro-2-thiazolyl)acetamide;2-Acetamido-5-nitrothiazole;Acetyl enheptin;Acinitrazole;Aminitrozole;Enheptin A;Pleocide;Trichlorad;Trichorad;Trichoral;Tricolaval;Tritheon;Lavoflagin;2-(Acetylamino)-5-nitrothiazole;5-Nitro-2-acetamidothiazole;Gynofon;Cyzine Premix;Nitazol;Trichocid;Acinitrazol;Trikolaval;Tricosteril;Ametoterina;Aminitrozol;Tricogen;Trichoman;Tricoral;Nithiamide;Nitazole;CL 5279;NSC 31539;NSC 45914;N-(5-Nitro-1,3-thiazol-2-yl)acetamide;8028-25-9;176976-49-1
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CAS No:
Description
Yellow-brown solid
Aminitrozole is an aromatic amide and a member of acetamides.|Nithiamide is an orally available antiprotozoan agent used in the treatment of vaginal trichomoniasis.
2-(Acetylamino)-5-nitrothiazole Basic Attributes
187.18
187.18
167361
205-414-7
9CBM60191Z
759136|45914|31539
DTXSID6046391
C81722
29341000
Characteristics
116
1.3
1.546 (estimate)
264.5 °C
421°C at 760 mmHg
137.5ºC
1.6560 (estimate)
Oral-rat LD50: >400 mg/kg; Oral-Mouse LD50: 1000 mg/kg
Flammable; decomposes by heating to release toxic nitrogen oxides and sulfur oxide fumes
Safety Information
NONH for all modes of transport
22
22-36/37-24/25
XJ1570000
Xn
Warehouse ventilated, low temperature and dry
P264, P270, P301+P312, P330, P501
H302
|Warning|H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]|P264, P270, P301+P312, P330, and P501|Aggregated GHS information provided by 46 companies from 3 notifications to the ECHA C&L Inventory.
2-(Acetylamino)-5-nitrothiazole Use and Manufacturing
General procedure: To a solution of 2-amino-5-nitrothiazole (0.3 g, 0.0020 mol) in dichloromethane was added 1.2 molar equiv of triethylamine (TEA). After the reaction mixture was stirred at 5 °C for 15 min, acetic anhydride (0.0100 mol, 5 equiv), or respectively acyl chlorides (0.0022 mol, 1.1 equiv) were added drop-wise. The reaction mixture was stirred at room temperature for 4–24 h. After complete conversion, the solvent was removed in vacuo and the residue was neutralized with saturated NaHCO
antiinflammatory, glucocorticoid
Computed Properties
Molecular Weight:187.18
XLogP3:1.3
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:1
Exact Mass:187.00516220
Monoisotopic Mass:187.00516220
Topological Polar Surface Area:116
Heavy Atom Count:12
Complexity:205
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
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