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2-(Acetylamino)-5-nitrothiazole

2-(Acetylamino)-5-nitrothiazole structure

CAS No:
140-40-9
Formula:
C5H5N3O3S
Chemical Name:
2-(Acetylamino)-5-nitrothiazole
Synonyms:
Acetamide,N-(5-nitro-2-thiazolyl)-;Thiazole,2-acetamido-5-nitro-;N-(5-Nitro-2-thiazolyl)acetamide;2-Acetamido-5-nitrothiazole;Acetyl enheptin;Acinitrazole;Aminitrozole;Enheptin A;Pleocide;Trichlorad;Trichorad;Trichoral;Tricolaval;Tritheon;Lavoflagin;2-(Acetylamino)-5-nitrothiazole;5-Nitro-2-acetamidothiazole;Gynofon;Cyzine Premix;Nitazol;Trichocid;Acinitrazol;Trikolaval;Tricosteril;Ametoterina;Aminitrozol;Tricogen;Trichoman;Tricoral;Nithiamide;Nitazole;CL 5279;NSC 31539;NSC 45914;N-(5-Nitro-1,3-thiazol-2-yl)acetamide;8028-25-9;176976-49-1
Categories:
Analytical Chemistry > Standard

Description

Yellow-brown solid

Aminitrozole is an aromatic amide and a member of acetamides.|Nithiamide is an orally available antiprotozoan agent used in the treatment of vaginal trichomoniasis.

2-(Acetylamino)-5-nitrothiazole Basic Attributes

Molecular Weight：

187.18

Exact Mass：

187.18

BRN：

167361

EC Number：

205-414-7

UNII：

9CBM60191Z

NSC Number：

759136|45914|31539

DSSTox ID：

DTXSID6046391

NCI Thesaurus Code：

C81722

HScode：

29341000

Characteristics

PSA：

116

XLogP3：

1.3

Density：

1.546 (estimate)

Melting Point：

264.5 °C

Boiling Point：

421°C at 760 mmHg

Flash Point：

137.5ºC

Refractive Index：

1.6560 (estimate)

Toxicity：

Oral-rat LD50: >400 mg/kg; Oral-Mouse LD50: 1000 mg/kg

Flammability characteristics：

Flammable; decomposes by heating to release toxic nitrogen oxides and sulfur oxide fumes

Safety Information

Transport codes：

NONH for all modes of transport

hazard class code：

safety instructions：

22-36/37-24/25

RTECS Number：

XJ1570000

Marks：

Storage features：

Warehouse ventilated, low temperature and dry

Precautionary statement(s)：

P264, P270, P301+P312, P330, P501

Hazard Statements：

H302

GHS Classification：

|Warning|H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]|P264, P270, P301+P312, P330, and P501|Aggregated GHS information provided by 46 companies from 3 notifications to the ECHA C&L Inventory.

Toxicity

Toxicity class：

moderately toxic

Drug Information

MeSH Entry Terms：

2-acetylamino-5-nitrothiazole

2-(Acetylamino)-5-nitrothiazole Use and Manufacturing

Methods of Manufacturing

General procedure: To a solution of 2-amino-5-nitrothiazole (0.3 g, 0.0020 mol) in dichloromethane was added 1.2 molar equiv of triethylamine (TEA). After the reaction mixture was stirred at 5 °C for 15 min, acetic anhydride (0.0100 mol, 5 equiv), or respectively acyl chlorides (0.0022 mol, 1.1 equiv) were added drop-wise. The reaction mixture was stirred at room temperature for 4–24 h. After complete conversion, the solvent was removed in vacuo and the residue was neutralized with saturated NaHCO

Uses

antiinflammatory, glucocorticoid

Computed Properties

Molecular Weight:187.18
XLogP3:1.3
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:1
Exact Mass:187.00516220
Monoisotopic Mass:187.00516220
Topological Polar Surface Area:116
Heavy Atom Count:12
Complexity:205
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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2-ACETAMIDO-5-NITROTHIAZOLE

CAS No.: 140-40-9

Content: 99.00%

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Guide of 2-(Acetylamino)-5-nitrothiazole

Description
Basic Attributes
Characteristics
Safety Information
Toxicity
Drug Information
Use and Manufacturing
Computed Properties
Recommended Suppliers
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2-(Acetylamino)-5-nitrothiazole

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