8-(9-Fluorenylmethoxycarbonylamino)-3,6-dioxaoctanoic acid
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8-(9-Fluorenylmethoxycarbonylamino)-3,6-dioxaoctanoic acid
structure -
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CAS No:
166108-71-0
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Formula:
C21H23NO6
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Chemical Name:
8-(9-Fluorenylmethoxycarbonylamino)-3,6-dioxaoctanoic acid
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Synonyms:
3,6,11-Trioxa-9-azadodecanoic acid,12-(9H-fluoren-9-yl)-10-oxo-;2,7,10-Trioxa-4-azadodecan-12-oic acid,1-(9H-fluoren-9-yl)-3-oxo-;12-(9H-Fluoren-9-yl)-10-oxo-3,6,11-trioxa-9-azadodecanoic acid;8-(9-Fluorenylmethoxycarbonylamino)-3,6-dioxaoctanoic acid;9-Fluorenylmethoxycarbonyl-8-amino-3,6-dioxaoctanoic acid;8-(Fmoc-amino)-3,6-dioxaoctanoic acid;[2-[2-(9H-Fluoren-9-ylmethoxycarbonylamino)ethoxy]ethoxy]acetic acid;Fmoc-NH-PEG2-CH2COOH;1-(9H-Fluoren-9-yl)-3-oxo-2,7,10-trioxa-4-azadodecan-12-oic acid;Fmoc-aeea;2-[2-[2-(9H-Fluoren-9-ylmethoxycarbonylamino)ethoxy]ethoxy]acetic acid;2-[2-[2-([[(9H-Fluoren-9-yl)methoxy]carbonyl]amino)ethoxy]ethoxy]acetic acid;1776111-66-0;2096497-78-6
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CAS No:
Description
Fmoc-8-amino-3,6-dioxaoctanoic acid (Fmoc-NH-PEG2-CH2COOH) is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].
8-(9-Fluorenylmethoxycarbonylamino)-3,6-dioxaoctanoic acid Basic Attributes
385.41
385.41
DTXSID50373231
29189900
Characteristics
94.1
2.4
White Crystalline Powder
1.3±0.1 g/cm3
90-92℃
631.4°C at 760 mmHg
335.6±28.7 °C
1.580
-15°C
Safety Information
3
22-24/25
P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, P501
H315
|Warning|H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]|P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, and P501|Aggregated GHS information provided by 2 companies from 2 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
8-(9-Fluorenylmethoxycarbonylamino)-3,6-dioxaoctanoic acid Use and Manufacturing
Hydrophillic spacer group.
Computed Properties
Molecular Weight:385.4
XLogP3:2.4
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:11
Exact Mass:385.15253745
Monoisotopic Mass:385.15253745
Topological Polar Surface Area:94.1
Heavy Atom Count:28
Complexity:491
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
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8-(9-Fluorenylmethoxycarbonylamino)-3,6-dioxaoctanoic acid
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