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Mirtazapine

Mirtazapine structure

CAS No:
61337-67-5
Formula:
C17H19N3
Chemical Name:
Mirtazapine
Synonyms:
1,2,3,4,10,14B-HEXAHYDRO-2-METHYLPYRAZINO[2,1-A]PYRIDO[2,3-C][2]BENZAZEPINE;1,2,3,4,10,14b-Hexahydro-2-methylpyrazino[2,1-α]pyrido[2,3-c][2]benzazepine;Mirtazepine, 1,2,3,4,10,14b-Hexahydro-2-methylpyrazino[2,1-a]pyrido[2,3-c][2]benzazepine;ORG-3770;REMERON;1,2,3,4,10,14b-Hexahydro-2-methylpyrazino[2,1-a]pyrido[2,3-c]benzazepine;1-a)pyrido(2,3-c)(2)benzazepine,1,2,3,4,10,14b-hexahydro-2-methyl-pyrazino(;2-Methyl-1,2,3,4,10,14b-hexahydropyrazino[2,1-a]pyrido[2,3-c][2]benzazepine
Categories:
Analytical Chemistry > Standard

Description

White Crystalline Solid

Mirtazapine is an antidepressant launched in the Netherlands. Mirtazapine is a potent antagonist of presynaptic α2 receptors as well as a moderately potent 5-HT antagonist. Studies suggested that blockade of α2-adrenoceptors, but not inhibition of noradrenaline uptake, is involved in the mechanism of the antidepressant action of mirtazapine. Mirtazapine has demonstrated efficacy in various studies in depressed patients, being equal or more potent than mianserin, amitriptyline, etc. and exhibiting less anticholinergic and gastrointestinal side effects and low cardiovascular toxicity. In addition to its antidepressant effects, studies in animals indicated that mirtazapine has anxiolytic andor hypnotic activity.

ChEBI: Mirtazapine is a benzazepine and a tetracyclic antidepressant. It has a role as an alpha-adrenergic antagonist, a serotonergic antagonist, a histamine antagonist, an anxiolytic drug, a H1-receptor antagonist and a oneirogen.

Mirtazapine (Remeron) is another example of tetracyclicα2-blockers that shows selectivity for α2-receptorsversus 1-receptors. Blockade of central α2-receptors resultsin an increased release of NE and serotonin. This hasprompted its use as an antidepressant. This agent also hasactivity at nonadrenergic receptors. It is a potent blockerof 5-HT2 and 5-HT3 serotonin receptors and at histamineH1-receptors.

Mirtazapine (Remeron) was recently introduced for clinicaluse in the United States; its parent mianserin (pyridyl N replacedwith C-H) was long known to be an antidepressant.It is reported to be faster acting and more potent than certainSSRIs. The mode of action gives increased NE release viaα2-NE receptor antagonism and increased 5-HT release viaantagonism of NE α2 heteroreceptors located on serotoninergicneurons.

Mirtazapine Basic Attributes

Molecular Weight：

265.35

Exact Mass：

265.35

EC Number：

641-354-1

Color/Form：

white

HScode：

2933990090

Characteristics

PSA：

19.4

XLogP3：

2.9

Appearance：

white solid

Density：

1.2±0.1 g/cm3

Melting Point：

114-116°C

Boiling Point：

432.4±45.0 °C at 760 mmHg

Flash Point：

9℃

Refractive Index：

1.668

Water Solubility：

H2O: Slight soluble ;DMSO: ~8 mg/mL, soluble

Storage Conditions：

2-8°C

PKA：

pKa 7.1(47% MeOH in H2O,t =25,I=0.15(KCl)) (Uncertain)

Critical Temperature & Pressure：

2-8°C

Safety Information

Transport codes：

UN1230 - class 3 - PG 2 - Methanol, solution

wgk germany：

hazard class code：

F,T

safety instructions：

22-24/25-45-36/37-16-7

Marks：

F,T

Precautionary statement(s)：

P210-P260-P280-P301 + P310-P311

Hazard Statements：

11-23/24/25-39/23/24/25

RIDADR：

UN1230 - class 3 - PG 2 - Methanol, solution

Mirtazapine Use and Manufacturing

An a 2-Adrenergic blocker. An analogue of Mianserin. Antidepressant

antidepressant;antagonist at the H1, 5-HT2A, 5-HT2C, 5-HT3, and a2-adrenergic receptors, in that order of potency

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