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Home > Active Pharmaceutical Ingredients > Antipyretic Analgesics (Find 171 items)

Antipyretic Analgesics

Dipyrone

(68-89-3)
Dipyrone is a non-steroidal anti-inflammatory drug that, when coadministered with morphine, potentiates its antinociceptive action and delays the development of tolerance. Dipyrone is a relatively selective inhibitor of cyclooxygenase-3 (COX-3), with lower activity against COX-1 and no activity against COX-2. Dipyrone blocks PGE2-induced hyperalgesia in several models.

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Indomethacin

(53-86-1)
antiinflammatory, antipyretic, analgesic.The product has anti-inflammatory and antipyretic effects, and is mainly used for rheumatoid arthritis, ankylosing spondylitis, osteoarthritis, etc., which are not easy to tolerate or have no significant effect on salicylic acid drugs. Uses are non-hormonal anti-inflammatory analgesics. Uses are cyclooxygenase (COX) inhibitors, which selectively inhibit COX-1; block the biosynthesis of prostate cord. It has anti-inflammatory and antipyretic effects in med

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Mefenamic acid

(61-68-7)
Anti-inflammatory; analgesic.

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Salicylamide

(65-45-2)
The main medical applications of salicylamine lie in its analgesic (pain relief) and antipyretic (fever reduction) properties. Similar to its close relative aspirin, salicylamine is used as a non-narcotic analgesic and anti-rheumatic, which can relieve various types of pain and inflammation. In addition, salicylamine has been used in combination with other active ingredients (such as aspirin and caffeine) for over-the-counter painkillers, further expanding its therapeutic application. Salicylamine's versatility goes beyond its medical use. Researchers and industry have explored the compound's potential in other areas, including its use as a chemical intermediate for synthesizing more complex organic molecules and its use in specialized industrial processes. The unique physicochemical properties of salicylamide, such as sublimation behavior and dissolution properties, have also generated interest in its potential uses in various technical and engineering applications. As researchers and medical professionals continue to study the properties and potential applications of salicylamine, this versatile compound is likely to maintain its relevance in fields such as pharmaceuticals, chemistry, and more, contributing to the advancement of human health and scientific knowledge. In pharmacology, salicylamine is known for its excellent anti-inflammatory, analgesic and antipyretic properties. Its mechanism of action mainly involves inhibiting the synthesis of prostaglandins, a body substance that plays a key role in pain and inflammatory responses. For this reason, salicylamine is commonly used to treat headaches, muscle pain, arthritis, and fever caused by colds and flu. In addition, salicylamine also shows certain antibacterial and antifungal activity, which makes it potential for topical application in the treatment of skin infections and inflammation. In some cases, it may be used as an alternative to antibiotics, reducing the risk of over-dependence on antibiotics. In the medical field, salicylamine is used as an active ingredient in over-the-counter and prescription drugs, such as non-steroidal anti-inflammatory drugs and certain antimalarial drugs. Because it is less irritating to the gastrointestinal tract, salicylamine may be a better option for patients who cannot tolerate other NSaids, such as aspirin. However, it is important to note that salicylamine may also cause some side effects, such as nausea, stomach upset, or allergic reactions. Therefore, when using any product containing salicylamine, you should follow the advice of your doctor or pharmacist and be aware of possible adverse reactions. Salicylamine has become an important molecule in the pharmaceutical industry due to its unique pharmacological properties, wide range of therapeutic applications and relatively low side effects. With the deepening of scientific research, we may find more new ways to use salicylamine to treat various diseases.

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Flurbiprofen

(5104-49-4)
antiinflammatory, analgesic

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(-)-Flurbiprofen

(51543-40-9)
(R)-2-Flurbiprofen is the R-isomer of Flurbiprofen (F598700), an anti-inflammatory used as an analgesic.

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Phenylbutazone

(50-33-9)
Phenylbutazone, a nonsteroidal anti-inflammatory drug, is an efficient reducing cofactor for the peroxidase activity of COX. Phenylbutazone-dependent inactivation of COX and prostacyclin synthase is markedly increased in the presence of 100 μM hydrogen peroxide with half-maximal effects at Phenylbutazone concentrations of 100 and 25 μM for COX and prostacyclin synthase, respectively.

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Flunixin meglumine

(42461-84-7)
1. Dental carries prophylactic
2. Cyclooxigenase inhibitor. Anti-inflammatory; analgesic; antipyretic.

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Zolmitriptan

(139264-17-8)
adrenergic agonist, nasal decongestant

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Sumatriptan

(103628-46-2)
Serotonin 5HT1 receptor agonist; treatment of migraine.

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Antipyretic Analgesics refer to drugs that can restore the body temperature of fever patients to normal, but have no effect on the body temperature of normal people. Such drugs also have moderate analgesic effects, but their strength is not as strong as morphine and its synthetic substitutes. Commonly used Antipyretic Analgesics can be divided into salicylic acid, aniline and pyrazolone according to their chemical structure. The "ECHEMI Antipyretic Analgesics" list mainly supplies APIs for such drugs.

Frequently Asked Questions

What are Antipyretic Analgesics and how do they work?

Antipyretic analgesics are medications that reduce fever (antipyretic effect) and relieve pain (analgesic effect). Common examples include acetaminophen (paracetamol), ibuprofen, and aspirin. These drugs primarily work by inhibiting the production of prostaglandins—chemicals in the body that promote inflammation, pain, and fever—through the suppression of cyclooxygenase (COX) enzymes. Understanding their mechanism helps in selecting the right medication based on patient needs and safety profiles.

What is the difference between antipyretic analgesics and NSAIDs?

While all NSAIDs (Non-Steroidal Anti-Inflammatory Drugs) like ibuprofen and naproxen are antipyretic analgesics, not all antipyretic analgesics are NSAIDs. For example, acetaminophen reduces fever and pain but has minimal anti-inflammatory effects and does not significantly inhibit COX-1 or COX-2 in peripheral tissues. In contrast, NSAIDs provide strong anti-inflammatory action along with antipyretic and analgesic effects. This distinction is crucial when choosing treatment for conditions involving inflammation versus simple pain or fever.

Are there safety concerns when using antipyretic analgesics?

Yes, antipyretic analgesics can pose safety risks if misused. Acetaminophen overdose may cause severe liver damage, while long-term or high-dose use of NSAIDs like ibuprofen can lead to gastrointestinal bleeding, kidney issues, or cardiovascular complications. It’s essential to follow recommended dosages, avoid combining multiple products containing the same active ingredient, and consult a healthcare provider—especially for patients with pre-existing conditions such as liver disease, ulcers, or heart problems.

Which antipyretic analgesic is safest for children?

Acetaminophen (paracetamol) and ibuprofen are generally considered safe for children when used at appropriate doses based on weight and age. Acetaminophen is often preferred for mild fever or pain due to its gentler effect on the stomach, while ibuprofen may be more effective for inflammatory conditions like sore throats or injuries. Aspirin should be avoided in children and teenagers due to the risk of Reye’s syndrome, a rare but serious condition. Always use pediatric formulations and consult a pediatrician before administration.

How are antipyretic analgesics used in pharmaceutical manufacturing?

In pharmaceutical manufacturing, antipyretic analgesics serve as active pharmaceutical ingredients (APIs) in a wide range of over-the-counter (OTC) and prescription medications. They are formulated into tablets, capsules, syrups, and injectables for global distribution. Manufacturers must adhere to strict Good Manufacturing Practices (GMP), ensure raw material quality, and conduct rigorous stability and purity testing. Reliable sourcing of high-purity APIs and intermediates is critical to meet regulatory standards from agencies like the FDA and EMA.

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