Clariant launches Mulberry root extract to fight skin aging

On September 1, Clariant's active ingredients business chain launched Prenylium, the first product launched after establishing a new partnership with French biotechnology company Plant Advanced Technologies (PAT). Prenylium is rich in rare flavonoids. It is a unique mulberry root extract that can effectively protect the skin matrix from the erosion of time and ultraviolet rays. Prenylium can also significantly reduce the appearance of wrinkles, improve skin smoothness, and help delay signs of aging.

Prenylium is produced through PAT’s patented plant milking technology, which can explore the normally inaccessible part of the plant-the roots, without destroying the trees, and allows the production of industrial-grade rare compounds. This highly sustainable, 100% traceable and eco-friendly process focuses on an innovative air-planted soilless system that can stimulate the root system to produce a higher number of targeted molecules than the natural environment. Without disrupting plant cultivation, the roots can be cut and collected from the same plant multiple times a year to obtain the required molecules; the root system can also be regenerated multiple times.

Prenylium contains a very high concentration of flavonoids, which is 2000% higher than the traditional mulberry root extract, and has stronger efficacy and performance.

Compared with a large number of nonflavonoids that are more common in nature, this type of biologically active

The skin matrix is a collection of all genetically coded elements, which help to enhance the integrity of the matrix and the physiological functions of the skin.

Prenylium has been shown in vitro to regulate the expression of CCN1-CCN1 is a protein that increases with age-thereby helping to protect the integrity of the matrix. Therefore, due to its unique active ingredients, Prenylium can rebalance the balance between collagen synthesis and degradation.

PAT's target binding patented technology makes it possible to evaluate the interaction between flavonoids and collagenase, which is an enzyme that induces collagen damage. All active compounds of Prenylium have the effect of inhibiting collagenase activity. Therefore, compared with traditional mulberry root extracts, the concentration of these specific polyphenols is more interesting and is also indispensable for the pursuit of better efficacy.

At the clinical level, we have seen strong results. It has achieved rapid and significant effects in reducing the appearance of wrinkles and improving the smoothness and plumpness of the skin. In a double-blind randomized study, the subjects were 22 wrinkled women, aged between 45 and 70 years, one group used a product containing 1% Prenylium twice a day, and the other group used a placebo . The results were analyzed after 4 and 8 weeks of use.

The data showed that over time, a group of wrinkles using Prenylium products gradually decreased. Deep wrinkles decreased by 12.7% after 4 weeks, and 16.6% after 8 weeks. The data also showed that the smoothness of the subjects' skin has been improved, which helps to keep the skin young. Skin plumpness increased by 13.4% after 8 weeks.

The diverse advantages of Prenylium make it suitable for a wide range of applications, including anti-aging creams, moisturizing essences, dermal matrix preventive care, repair night creams and other smooth skin products. Recently, Prenylium also won the PCHi 2020 Fangdian Award for its outstanding effects in "anti-aging".

Alexandre Lapeyre, Marketing Director of Clariant’s Active Ingredients Business Chain, said: “Prenylium can maintain key skin matrix ingredients and protect the skin from time and ultraviolet rays. It is a market-friendly active ingredient especially favored by skin care formulators and can help formula The teacher actively develops effective skin care solutions for the "anti-aging" group. In addition, through the controllable cultivation environment and the sustainable acquisition of tree roots, the traceability and reliability of product ingredients can be guaranteed, which is important for ensuring beauty The sustainable development of the industry in the future is very important. We are very pleased to start cooperation with PAT to obtain active ingredients through unique root extraction technology, thereby protecting the growth cycle of the plant. This truly reflects our commitment to “powering by nature and using technology Be the leader's promise."