Neomycin Sulfate Combined With Amoxicillin Can Significantly Enhance Antibacterial And Therapeutic Effects

Neomycin for veterinary use, kanamycin and gentamicin are all aminoglycoside antibiotics, and neomycin sulfate soluble powder is currently the most widely used in veterinary clinical treatment. Its qualified properties are white or off-white crystalline powder, which is a raw material obtained by semi-synthesis after biological fermentation; it is easily soluble in water, and the aqueous solution is acidic; its stability in drinking water is very good, and its nephrotoxicity for injection is relatively high. Strong, which is also the reason why it is mainly administered orally in large quantities in livestock and poultry veterinary clinics.

Typically, the intact gastrointestinal tract absorbs very little (generally no more than 3%) of orally ingested neomycin sulfate. However, if the gastrointestinal tract is ulcerated, the mucous membrane is detached or there is inflammation, the gastrointestinal tract will absorb a considerable amount of neomycin sulfate. Neomycin sulfate entering the body can be distributed to the heart, liver, spleen, lung, kidney and other organs and some tissues, but the dose of a single drug absorbed into the body by oral administration is far from the effective therapeutic dose.

Therefore, unless the application of special preparation technology has greatly improved the bioavailability of a single drug, or because of the support of the overall formula technology embodied in the product treatment (such as Zoetis' new fertilizer (neomycin sulfate soluble powder), most veterinary drugs The neomycin sulfate soluble powder produced by the manufacturer is an ordinary preparation product without any pharmacodynamic technology, and only has an effective therapeutic effect on the intestinal tract in the clinical manifestation of veterinary treatment.

The antibacterial effect of neomycin sulfate is that it first enters the bacterial cell, and then can be combined with the 30S subunit of the ribosome, thereby inhibiting the synthesis of bacterial protein and achieving the bactericidal effect. The antibacterial effect of amoxicillin is achieved by irreversibly destroying the bacterial cell wall, thereby achieving a rapid sterilization effect. It can be seen that the combination of neomycin sulfate and amoxicillin into a veterinary prescription, amoxicillin opens the door for neomycin sulfate to freely enter bacterial cells, and this synergistic effect can significantly enhance the single drug neomycin sulfate, adria Antibacterial efficacy of moxicillin.

Neomycin sulfate absorbed into the body can be rapidly distributed to various tissues and organs throughout the body. Among them, the highest concentration is distributed in the heart, liver and kidney, and it is mainly concentrated in nucleated cells (higher content in white blood cells). Within 24h, about 12% to 25% of neomycin sulfate is excreted by the kidneys; about 50% to 90% is excreted by the bile, so it has a better effect on the intestinal tract. Since neomycin sulfate absorbed into the body is slowly released from storage tissues, the plasma elimination half-life of neomycin sulfate is relatively long, about 36 hours.

Amoxicillin is a bio-fermentative semi-synthetic drug, which belongs to oral penicillin antibiotics in the pharmaceutical classification. In the field of penicillin antibiotics, most of them require injection to be effective, and there are very few effective drugs that can be used orally. Amoxicillin is relatively stable under acidic and weak alkaline conditions, and its oral bioavailability can reach 90%. Its effect on sensitive bacteria is mainly to kill (many antibiotics only inhibit the growth and reproduction of bacteria), and the effective contact time with pathogenic bacteria will have a great impact on its clinical treatment effect.

Oral absorption of amoxicillin is better. Such a large amount of amoxicillin entering the body can play a synergistic antibacterial effect with a large amount of neomycin sulfate that has entered the body. The effective therapeutic dose of this synergistic antibacterial neomycin sulfate only requires amoxicillin than new A 5:1 amount of mycin is sufficient. Calculated in this way, the effective amoxicillin absorbed into the body by oral intake ensures that it is not less than 20mg/kg body weight, then only 4mg/kg body weight of neomycin sulfate is needed to make the prescription of "neomycin sulfate + amoxicillin" very good. 

Therefore, in the treatment of livestock and poultry for a variety of bacterial infectious diseases, the combination of technical neomycin sulfate products (mainly absorption or overall prescription effect) and amoxicillin products can significantly enhance neomycin sulfate Antibacterial and therapeutic effects of suetidine and amoxicillin as single agents. In addition, this combination of different types of drugs also has dual antibacterial mechanisms and anti-drug resistance, thereby reducing the increase in the resistance rate of pathogenic microorganisms in this field. Long-term statistics show that this has a significant effect on reducing the use of antibiotics.