Get More About Antipyretic

Antipyretic Definition

Antipyretic drugs are a class of drugs with antipyretic, and most of them also have anti-inflammatory and anti-rheumatic effects. The mechanism of action is to inhibit the biosynthesis of prostaglandin (PG) in the body. Due to its special anti-inflammatory effect, this class of drugs is also called non-steroidal anti-inflammatory drugs.

Some Given Antipyretic Examples

◇ Ibuprofen

Ibuprofen is also known as ibuprofen and its chemical name is 2-(4-isobutylphenyl)propionic acid. It is a new generation of non-steroidal anti-inflammatory and analgesic drugs, suitable for the treatment of rheumatoid arthritis and rheumatoid arthritis. Arthritis, osteoarthritis, ankylosing spondylitis, neuritis, pharyngitis and bronchitis, etc., have stronger antipyretic, anti-inflammatory and analgesic effects than aspirin, and their side effects are much smaller than aspirin.

◇ Analgin

Analgin was once the best-selling antipyretic drug in the country, but due to its fatal side effects, it has been banned from sale, withdrawn from the market or restricted in use in nearly 30 foreign countries. At present, entering "Analgin Tablets" on the official website of the State Food and Drug Administration can also inquire about 845 related Chinese medicine quasi-brand names. 

◇ Paracetamol

During the global fight against the new crown pneumonia epidemic, as the most popular antipyretic and analgesic drug, paracetamol has been unanimously recommended by WHO experts and doctors from all over the world because of its better antipyretic and analgesic effect and safety. The market demand is strong.

◇ Phenacetin

Functional groups in phenacetin play a significant role in the functionalities of organic molecules. Phenacetin is no exception. Phenacetin is used as a pain reliever and antipyretic, reducing fever by lowering body temperature. In addition to these uses, phenacetin is also known for its presence in over-the-counter painkillers such as Excedrin or Anacin.

◇ Some natural plants

Among the common herbal tea ingredients, chrysanthemum, honeysuckle, Prunella vulgaris and licorice belong to the category of antipyretic drugs. They are cold in nature and have the functions of clearing heat and purging fire, cooling blood and detoxifying, diuresis and cooling liver.

Antipyretic Trade and Price Trends

● Increased export growth potential, both volume and price of API inclined

Antipyretic drugs are indispensable drugs in the treatment of new coronary pneumonia characterized by fever. China is a major producer and exporter of paracetamol, ibuprofen, analgin, and other antipyretic and analgesic APIs, with exports reaching US $ 640 million in 2019. Among them, paracetamol, which has good safety, has only antipyretic and analgesic effect, and no anti-inflammatory effect, has been recommended by WHO experts and doctors from various countries, causing a large number of foreign people to buy it.

● Import and export of foreign trade and the impact of national policy

In the early stage of the epidemic, foreign trade business was greatly affected and almost stopped. As a result, the domestic prices of sulfonamide products fell, which eased the perennial tight supply situation. Antipyretic and analgesic products have risen worldwide due to the epidemic.

● Monthly tracking report of pharmaceutical biological APIs

the market quotations of various vitamins are generally stable and strong, with varying degrees of increase, mainly due to the market driven by replenishment in the new year. Among them, large varieties such as VA and VE are worthy of attention. Due to a supply gap in the expansion of BASF's production line, VE prices have rebounded; antipyretic and analgesic and hormones and other bulk APIs are not significant Variety.

● Upstream changes, the export price of paracetamol APIs will skyrocket?

China is the world's largest producer and exporter of Paracetamol raw materials, with production capacity accounting for about half of the world; it is also the world's largest producer and exporter of para-AMINOPHENOL, with a global production capacity as high as 80%, occupying an absolute dominant position. In 2019, my country exported 38,900 tons of paracetamol raw materials with an export value of 185 million US dollars, and an export volume of 36,700 tons of p-aminophenol, with an export value of approximately 124 million US dollars.

● Antipyretic price trend recently

Paracetamol -- Affected by upstream raw materials and other factors, domestic mainstream factories have firm quotations and concentrated supply (transactions are at 66-68 yuan/kg), and the market price index is running at a high level.

Carbaspirin calcium -- The supply of mainstream factories is generally, the factory production capacity is relatively scattered, and the market price index remains stable.