Clinical knowledge of fungal allergic asthma has a history of more than 200 years. In 1728, John Floyer reported that someone had a sudden asthma attack while visiting a brewery. In 1924, Von Leeuwen proposed that the cause of asthma in Dutch patients was humidity. In the same year, Cadhan reported three cases of asthma induced by wheat rust in the United States. These findings are the prototypes of research on fungal allergic asthma. In 1928, Dr. Hansen in Germany formally confirmed for the first time that 15% of asthma patients had a positive reaction to skin tests of Alternaria and Penicillium antigens collected in the living environment, and confirmed that inhalation of Alternaria or Penicillium spores in some patients could induce asthma attacks. In 1932, Tubs reported a case of an asthmatic child who developed the disease every time he ate fermented food, and proposed that yeast and Candida were the causes of some asthma patients. In 1934, Prince et al. observed the method of culturing fungi in the living environment of patients and found that when the fungi grew vigorously, the patient's asthma symptoms worsened.