Opium, morphine, codeine, paregoric and papaverine in this category are effective drugs for analgesia, cough relief, diarrhea relief, anesthesia and spasmolysis, and are widely used in clinical practice. Opium is commonly known as opium and opium. The main toxic component is morphine. Acute poisoning often causes death from respiratory paralysis. Misuse of large amounts or frequent use of morphine can cause poisoning. The poisoning dose of morphine for adults is 0.06g, and the lethal dose is 0.25g; the lethal dose of dry opium is 10 times that of morphine, and its oral lethal dose is 2 to 5g. The toxicity of codeine is 1/4 of that of morphine, and the toxic dose is 0.2g, and the lethal dose is 0.8g. Misuse of large amounts at one time or frequent use can cause poisoning. Barbiturates and other hypnotic drugs have synergistic effects with drugs in this category, so be cautious when using them together.