Extract from the above information

A broad-spectrum third-generation cephalosporin with a low MIC, very stable to beta-lactamase, widely distributed in body fluids and various organs, with few side effects and good stability. It has strong antibacterial activity against Enterobacteriaceae, and both influenza bacilli and gonococci that produce and do not produce beta-lactamase are highly sensitive to this product. It has stronger antibacterial effects on Escherichia coli, aerogenes, various Proteus species, and influenza bacilli than second-generation cephalosporins. It has stronger activity against gram-positive cocci such as hemolytic streptococci and pneumococci.

Bactericidal cephalosporin antibiotics that work by inhibiting bacterial cell wall synthesis. Effective against a broad spectrum of Gram-positive and Gram-negative bacteria, resistant to most beta-lactamases. Effective against many pathogenic strains and pathogens associated with hospital-acquired infections, including strains resistant to gentamicin and other aminoglycosides. When used in combination with aminoglycoside antibiotics, the efficacy is at least additive, with significant synergistic effects against some strains.

Ampicillin sodium is a broad-spectrum semi-synthetic penicillin. This product has a strong antibacterial effect on hemolytic streptococci, Streptococcus pneumoniae and non-penicillinase-producing Staphylococci, which is similar to or slightly inferior to penicillin. Ampicillin also has a good antibacterial effect on viridans streptococci, and is better than penicillin on enterococci and Listeria. This product has antibacterial activity against Corynebacterium diphtheriae, Bacillus anthracis, Actinomyces, Haemophilus influenzae, Bordetella pertussis, Neisseria and anaerobic bacteria except Bacteroides fragilis. Some Proteus mirabilis, Escherichia coli, Salmonella and Shigella are sensitive to this product. Ampicillin exerts its bactericidal effect by inhibiting bacterial cell wall synthesis.

When used in combination with sulbactam sodium, it can reduce the MIC of Staphylococcus aureus, Haemophilus influenzae, Escherichia coli, Bacteroides fragilis, etc., which are resistant to penicillins and cephalosporins due to enzyme production, to within the sensitive range. It has a strong affinity for PBP1 of Bacillus paradoxalis.

This product is a semi-synthetic β-lactamase inhibitor. It has strong antibacterial activity against Neisseria gonorrhoeae, Neisseria meningitidis and Acinetobacter calcoaceticus. It has poor effects on other bacteria, but has strong and irreversible competitive inhibition of β-lactamase produced by Staphylococcus aureus and most Gram-negative bacteria. The concentration of 2mg/L has a strong inhibitory effect on Richmond classification type II, III, IV and V β-lactamase, but has a poor effect on type I β-lactamase. It has a strong affinity for PBP2 of Acinetobacter calcoaceticus.