Wuhan Humanwell Pharmaceutical Co., Ltd.

This product is a formyl derivative of tetrahydrofolate, mainly used for the rescue of high-dose methotrexate and other folic acid antagonists. It can be converted into tetrahydrofolate by tetrahydrofolate reductase, which can limit the damage of methotrexate to normal cells and reverse the reaction of methotrexate to bone marrow and gastrointestinal mucosa, but it has no obvious effect on the neurotoxicity caused by methotrexate.

The pharmacological effects are mainly exerted through its metabolite monohydroxy derivative (MHD). The mechanism of action of oxcarbazepine and MHD is mainly through blocking voltage-sensitive sodium channels, stabilizing overexcited neuronal cell membranes, inhibiting the repetitive discharge of neurons, and reducing the propagation of synaptic impulses. In addition, it also has an anticonvulsant effect by increasing potassium conductivity and regulating high-voltage activated calcium channels. No effect on brain neurotransmitters and regulatory receptors was found. In animal experiments, oxcarbazepine and its active metabolite (MHD) are a powerful and effective anticonvulsant drug that can prevent tonic-clonic seizures in rodents or reduce the severity of clonic seizures, and eliminate or reduce the effects of aluminum implants in the body.

This product is a congener of cyanocobalamin B12. It is an important coenzyme for the synthesis of nucleotides in cells, participates in methyl conversion and folic acid metabolism in the body, and promotes the reduction of methylfolate to tetrahydrofolate; it also participates in the tricarboxylic acid cycle, which is very important for the formation of lipoproteins in nerve myelin, and can keep sulfhydryl enzymes in an active state, thereby participating in a wide range of protein and fat metabolism. This product can promote the development and maturation of red blood cells, which is a necessary factor for the complete formation of nerve sheath spinal cord fibers and maintaining the function of epithelial cells in the digestive system.

Sodium nitroprusside is a fast-acting and short-acting vasodilator. It has a direct dilating effect on both arterial and venous smooth muscles, but does not affect the contraction of the uterus, duodenum or myocardium. Vasodilation reduces peripheral vascular resistance, thus having a hypotensive effect. Vasodilation reduces both the preload and afterload of the heart and improves cardiac output, so it is beneficial for heart failure. Reducing afterload can reduce the impedance of the aorta and left ventricle during valvular insufficiency and reduce reflux.

It has a broad-spectrum antibacterial effect, with high antibacterial activity against Candida species. Cryptococcus neoformans, Aspergillus, Mucor, Microsporum, Histoplasma capsulatum, Blastomyces dermatitidis and tinea are also usually sensitive to this product. Its mechanism of action is to combine with sterols on the fungal cell membrane, causing changes in cell membrane permeability, resulting in the leakage of important cell contents, thereby exerting an antifungal effect.

Multivitamins can enhance the repair of vaginal epithelial tissue.

Multivitamins can enhance the repair of vaginal epithelial tissue.

Multivitamins can enhance the repair of vaginal epithelial tissue.