Extract from the above information

It offsets the compensatory mechanism induced by diuretics, enhances the antihypertensive effect of diuretics, selectively blocks AT1 subtype receptors to exert antihypertensive effects, and weakens the increase in serum uric acid and decrease in blood potassium induced by hydrochlorothiazide.

It causes activation of the sympathetic nervous system and the renin-angiotensin system, counteracts the antihypertensive effect, and reduces blood potassium levels. Combination with irbesartan can enhance the antihypertensive effect.

Azasetron hydrochloride is a selective 5-HT3 receptor antagonist, which has a significant inhibitory effect on nausea and vomiting caused by anticancer drugs such as cisplatin. Animal studies have shown that the affinity of azasetron hydrochloride for the 5-HT3 receptor in the rat cerebral cortex is about 410 times stronger than that of metoclopramide, twice that of ondansetron, and basically the same as that of granisetron.

Animal experiments have shown that (1) Effects on smooth muscle: Various total flavonoid compounds in Pueraria root have the effect of relaxing smooth muscle; (2) Effects on body temperature: Oral administration of Pueraria root decoction or ethanol infusion can reduce the body temperature of febrile rabbits, and the effect of the infusion is particularly obvious; (3) Effects on the cardiovascular system: Pueraria root has a certain antihypertensive effect on normal and hypertensive animals. Pueraria root total flavonoids and puerarin have a significant effect of dilating coronary arteries, which can increase coronary blood flow, reduce vascular resistance, and inhibit thrombin-induced 5-HT release in platelets.

Animal experiments have shown the following: (1) Effects on smooth muscle: various total flavonoid compounds in Pueraria root have the effect of relaxing smooth muscle; (2) Effects on body temperature: Pueraria root can reduce the body temperature of artificially fevered rabbits; (3) Effects on the cardiovascular system: Pueraria root has a certain antihypertensive effect on normal and hypertensive animals. Pueraria root total flavonoids and puerarin have a significant effect of dilating coronary arteries, increasing coronary blood flow and reducing vascular resistance, and can also inhibit thrombin-induced 5-HT release in platelets.