Shandong Shenglu Pharmaceutical Co., Ltd.

This product can compete with histamine released from tissues for H20 receptors on effector cells, thereby preventing the onset of allergic reactions and relieving the spasmodic and congestive effects of histamine.

In the treatment of metabolic acidosis, this product increases the concentration of carbonate in plasma, neutralizes hydrogen ions, and thus corrects acidosis; alkalizes urine, because the pH value increases after the concentration of carbonate in urine increases, making it difficult for uric acid, sulfonamide drugs and hemoglobin to form crystals or aggregate in urine; and antacids, oral administration can quickly neutralize or buffer gastric acid without directly affecting gastric acid secretion. Therefore, the pH in the stomach increases rapidly to relieve symptoms caused by high gastric acid.

This product is an amide local anesthetic. After blood absorption or intravenous administration, it has obvious biphasic effects of excitation and inhibition on the central nervous system, and there may be no precursor excitation. When the blood concentration is low, analgesia and drowsiness occur, and the pain threshold increases; with increasing doses, the effect or toxicity increases, and there is an anticonvulsant effect at sub-toxic blood concentrations; when the blood concentration exceeds 5mu; gml-1, convulsions may occur. At low doses, this product can promote the outflow of potassium in myocardial cells, reduce the autonomy of the myocardium, and have an anti-ventricular arrhythmia effect; at therapeutic doses, it has no obvious effect on the electrical activity of myocardial cells, atrioventricular conduction, and myocardial contraction; further increases in blood concentrations can cause a slowing of cardiac conduction velocity, atrioventricular conduction block, inhibition of myocardial contractility, and a decrease in cardiac output.

It has a peripheral anti-M cholinergic receptor effect, can relieve smooth muscle spasms caused by acetylcholine, can also relieve microvascular spasms, improve microcirculation, relax gastrointestinal smooth muscle, and inhibit its peristalsis. Its effect is slightly weaker than atropine, and its effect of inhibiting digestive gland secretion is 1/10 of atropine. Its effect of inhibiting saliva secretion and dilating pupils is weaker, which is 1/20-1/10 of atropine. Because it is not easy to pass through the blood-cerebrospinal fluid barrier, its central effect is also weaker than atropine.

This product can cause blood vessels to contract, reduce capillary permeability, enhance platelet aggregation and adhesion, promote platelets to release coagulation active substances, shorten coagulation time, and achieve hemostatic effect.