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Etamsylate

Etamsylate structure

CAS No:
2624-44-4
Formula:
C6H6O5S.C4H11N
Chemical Name:
Etamsylate
Synonyms:
Benzenesulfonic acid,2,5-dihydroxy-,compd. with N-ethylethanamine (1:1);Benzenesulfonic acid,2,5-dihydroxy-,compd. with diethylamine (1:1);Benzenesulfonic acid,2,5-dihydroxy-,compd. with Et2NH;Diethylamine,2,5-dihydroxybenzenesulfonate;Ethanamine,N-ethyl-,2,5-dihydroxybenzenesulfonate;141 MD;Dicynene;Dicynone;Diethylammonium 2,5-dihydroxybenzenesulfonate;Ethamsylate;Cyclonamine;Eselin;Aglumin;Altodor;Etamsylate;2,5-Dihydroxybenzenesulfonic acid diethylamine salt;Dicinone;Biosinon;MD 141;E 141;K-Stat;Hemsyl;Sylate
Categories:
Active Pharmaceutical Ingredients > Blood System Drugs

Description

Ethamsylate is a haemostatic drug, also inhibits biosynthesis and action of those prostaglandins.

Etamsylate is a sulfonic acid derivative and an organosulfur compound.|Benzenesulfonate derivative used as a systemic hemostatic.

Etamsylate Basic Attributes

Molecular Weight：

263.31

Exact Mass：

263.082733

EC Number：

220-090-7

UNII：

24YL531VOH

DSSTox ID：

DTXSID4045559

ATC Code：

B02BX01|B - Blood and blood forming organs

HScode：

2922299090

Characteristics

PSA：

115

XLogP3：

2.43200

Appearance：

White crystals or crystalline powder

Density：

1.3441 (rough estimate)

Melting Point：

125 °C

Boiling Point：

496.4°C at 760 mmHg

Flash Point：

254ºC

Vapor Pressure：

1.13E-10mmHg at 25°C

Toxicity：

LD50 i.v. in mice, rats: 800, 1350 mg/kg (Esteve)

Safety Information

Hazard category：

IRRITANT

RTECS Number：

DB6145000

Precautionary statement(s)：

P201, P202, P281, P308+P313, P405, P501

Hazard Statements：

H361

GHS Classification：

|Warning|H319 (97.22%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]|P264, P280, P305+P351+P338, and P337+P313|Aggregated GHS information provided by 41 companies from 3 notifications to the ECHA C&L Inventory.

Drug Information

MeSH：

Agents acting to arrest the flow of blood. Absorbable hemostatics arrest bleeding either by the formation of an artificial clot or by providing a mechanical matrix that facilitates clotting when applied directly to the bleeding surface. These agents function more at the capillary level and are not effective at stemming arterial or venous bleeding under any significant intravascular pressure. (See all compounds classified as Hemostatics.)

MeSH Entry Terms：

Altodor

Etamsylate Use and Manufacturing

Uses

Hemostatic;prostaglandin synthesis inhibitor he product can increase the number, aggregation and adhesion of platelets, and promote the release of coagulation active substances from platelets. It can also accelerate the contraction of blood clots, shorten the clotting time, enhance the resistance of capillaries, and reduce capillary permeability. Used to prevent and treat bleeding before surgery. It is also used for bleeding caused by platelet insufficiency or other causes, such as gastrointestinal bleeding, cerebral hemorrhage and urinary tract bleeding.

Manufacturing Info：

Benzenesulfonic acid, 2,5-dihydroxy-, compd. with N-ethylethanamine (1:1): INACTIVE

Use Classification：

Human drugs -> Rare disease (orphan)

Computed Properties

Molecular Weight:263.31
Hydrogen Bond Donor Count:4
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:3
Exact Mass:263.08274382
Monoisotopic Mass:263.08274382
Topological Polar Surface Area:115
Heavy Atom Count:17
Complexity:252
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes

Material

Quinone

Drug Function and Efficacy

It can cause blood vessels to contract, reduce capillary permeability, enhance platelet aggregation and adhesion, promote platelets to release coagulation active substances, shorten coagulation time, and achieve hemostatic effect.

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Ethamethamide injection
Ingredients	Phenolsulfonylamine, chemical name: 2,5-dihydroxybenzenesulfonic acid diethylamine salt
Indication	Dextran inhibits platelet aggregation, prolongs bleeding and coagulation time, and theoretically has an antagonistic effect with this product.
Specifications	2ml: 0.5g
Manufacturer	Jiangsu Lianshui Pharmaceutical Co., Ltd.

Ethamethamide injection
Ingredients	Phenolsulfonylamine, chemical name: 2,5-dihydroxybenzenesulfonic acid diethylamine salt
Indication	Dextran inhibits platelet aggregation, prolongs bleeding and coagulation time, and theoretically has an antagonistic effect with this product.
Specifications	2ml:0.25g
Manufacturer	Xi'an Lijun Pharmaceutical Co.Limited

Ethamethamide injection
Ingredients	Phenolsulfonylamine, chemical name: 2,5-dihydroxybenzenesulfonic acid diethylamine salt
Indication	Dextran inhibits platelet aggregation, prolongs bleeding and coagulation time, and theoretically has an antagonistic effect with this product.
Specifications	5ml:1g
Manufacturer	Jilin Century Hanke Pharmaceutical Co., Ltd.

See More Related Drugs

Registered Holders

Double-Crane Pharmaceutical(Shangqiu) Co., Ltd.

China
Active
China Resources Double-Crane Pharmaceutical Co., Ltd.

China
Active
Hunan Er-Kang Pharmaceutical Co., Ltd.

China
Active

See More Registered Holders

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