Compound sodium chloride is a drug for replenishing body fluids and regulating water and electrolyte balance. Na and Cl- are important electrolytes in the body, mainly existing in extracellular fluid, and play a very important role in maintaining the normal volume and osmotic pressure of blood and extracellular fluid in the human body.

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This product is a blood volume expander. Its volume expansion effect and blood dilution effect depend on the molecular weight, degree of substitution, substitution pattern and drug concentration, as well as the dosage and infusion rate.

This product is a blood volume expander. Its volume expansion effect and blood dilution effect depend on the molecular weight, degree of substitution, substitution mode and drug concentration, as well as the dosage and infusion rate. After 500ml of this product was infused into healthy volunteers within 30 minutes, its volume expansion effect was 100% of the infusion volume of this product, and this 100% volume effect can be stably maintained for 4-6 hours. This product can maintain blood volume for at least 6 hours by isovolumetric blood replacement. In the subchronic toxicity test study of dogs and rats, this product was intravenously infused at 9g/kg body weight daily for 3 consecutive months, and no toxic reaction was found. During the administration period, due to the increase in liver and kidney stress response under non-physiological conditions, it can be observed that the reticuloendothelial system, liver parenchyma and other tissues of the test animals have increased uptake and metabolism of hydroxyethyl starch. The minimum toxic dose of this product for daily intravenous infusion is higher than 9g/kg body weight, which is equivalent to more than 3 times the maximum therapeutic dose of humans. Studies conducted in rats or rabbits have shown that this product has no teratogenic toxicity. When rabbits were infused with 10% hydroxyethyl starch 130/0.4 solution 50ml/kg daily, embryonic death was observed. When pregnant and lactating rats were given a single bolus of the above dose, delayed weight gain and growth of the pups were observed, and increased fluid load was observed in the mother. No studies have been conducted on the effects of this product on fertility.

This product is a commonly used contrast agent for X-ray and CT examinations, and can be used in blood vessels, spinal canals, and body cavities. Animal test results show that this product has an enhancement effect on dog liver, abdominal aorta, and CT scan images.

Cerebral vasodilators can inhibit phosphodiesterase activity, increase the effect of vascular smooth muscle relaxation messenger C-GMP, selectively increase cerebral blood flow, and also inhibit platelet aggregation, reduce human blood viscosity, enhance red blood cell deformability, improve blood fluidity and microcirculation, promote brain tissue uptake of glucose, increase brain oxygen consumption, and improve brain metabolism.