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Hangzhou Jiuyuan Genetic Biopharmaceutical Co., Ltd.
  • Founded in:

    1993-12-31
  • Country:

    China China
  • Address:

    No. 23, No. 8 Street, Baiyang Street, Qiantang District, Hangzhou City, Zhejiang Province
  • Tax NO.:

    91330100609130315G
  • Registered Funds:

    245.3988 million yuan
  • Website:

  • Email:

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The main ingredient of this product is palonosetron hydrochloride, chemical name: 2-[1-azabicyclo[2,2,2]oct-3S-yl]-2,3,3aS,4,5,6-hexahydro-1H-benzo[de]isoquinolin-1-one hydrochloride.
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Palonosetron Hydrochloride

Palonosetron is a selective antagonist of the 5-HT3 receptor with strong affinity, and has no affinity or low affinity for other receptors. The 5-HT3 receptor is located in the central and peripheral vagus nerve endings of the emetic chemotherapy receptor area in the medulla oblongata. Chemotherapy drugs stimulate the release of 5-HT by chromaffin cells in the small intestine, and 5-HT then activates the 5-HT3 receptors of the vagal afferent nerves, producing a vomiting reflex.

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Palonosetron is a selective antagonist of the 5-HT3 receptor with strong affinity, and has no affinity or low affinity for other receptors. The 5-HT3 receptor is located in the central and peripheral vagus nerve endings of the emetic chemotherapy receptor area in the medulla oblongata. Chemotherapy drugs stimulate the release of 5-HT by chromaffin cells in the small intestine, and 5-HT then activates the 5-HT3 receptors of the vagal afferent nerves, producing a vomiting reflex.

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One of the main cytokines that regulates granulocyte hematopoiesis in the bone marrow. It selectively acts on granulocyte hematopoietic progenitor cells, promotes their proliferation and differentiation, and increases the function of terminally differentiated granulocyte cells.

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