Compound Lophatherum gracile tablets
Function and Efficacy
This product was administered orally to experimental dogs with renal hypertension at a dose of 0.2g/kg, which significantly reduced blood pressure from 190/142 to 153/98mmHg 2 hours after oral administration. This product was administered orally to dogs and cats at 0.2 and 0.4g/kg, which slowed the heart rate 20 minutes later and lasted for 5 hours. This product was administered orally to rats at 0.3 and 0.6g/kg, which significantly counteracted arrhythmias caused by aconitine, calcium chloride and coronary artery ligation, and its anti-arrhythmic mechanism may be related to the effect on calcium ion influx. This product was administered orally to mice at 0.6 and 1.2g/kg, which reduced spontaneous activity in mice, and had a synergistic effect with sodium pentobarbital, causing the mice to lose their righting reflex.
Ingredients
Dry powder of Luobu Ma decoction, dry powder of wild chrysanthemum decoction, dry powder of Stephania tetrandra decoction, magnesium trisilicate, guanidine sulfate, dihydralazine sulfate, hydrochlorothiazide, promethazine hydrochloride, vitamin B1, vitamin B6, calcium pantothenate.
| Name | Description | Content | CAS NO. | Manufacturer |
|---|---|---|---|---|
| Magnesium trisilicateIngredients |
The pharmacological effect is not mentioned separately, but it may have certain auxiliary antihypertensive or antiarrhythmic effects. More |
14987-04-3 | 11 | |
| GUANOXAN SULFATEIngredients |
May be involved in the antihypertensive effect. More |
5714-04-5 | 1 | |
| OphthazinIngredients |
Participates in the blood pressure lowering effect. More |
484-23-1 | 0 | |
| HydrochlorothiazideIngredients |
Participates in the antihypertensive effect, possibly through a diuretic effect. More |
58-93-5 | 56 | |
| Promethazine hydrochlorideIngredients |
May be involved in sedation and reduction of spontaneous activity. More |
58-33-3 | 29 | |
| Thiamine chlorideIngredients |
The pharmacological effects are not mentioned separately, but it may serve as an auxiliary ingredient to improve the overall metabolic status. More |
59-43-8 | 9 | |
| Vitamin B6Ingredients |
The pharmacological effects are not mentioned separately, but it may serve as an auxiliary ingredient to improve the overall metabolic status. More |
8059-24-3 | 12 | |
| Calcium D-PantothenateIngredients |
The pharmacological effects are not mentioned separately, but it may serve as an auxiliary ingredient to improve the overall metabolic status. More |
137-08-6 | 8 |
Appearance
This product is a film-coated tablet, which is dark brown after removing the film coating; it tastes bitter.
Indication
Used for hypertension.
Usage and Dosage
Oral, usual dosage: three times a day, two tablets each time. Maintenance dosage: two tablets a day after blood pressure drops
Adverse Reactions
Oral administration of Lophatherum preparations often causes bowel sounds, diarrhea, occasional stomach pain, dry mouth and other adverse reactions, and some patients experience asthma and liver pain; cardiotoxicity is mainly bradycardia and premature contractions. Excessive use can cause sedation, drowsiness, fatigue, etc., and can also cause an increase in blood uric acid.
Precautions
Not yet clear.
Special Population Medication
Precautions for children: Not yet clear. Precautions for pregnancy and lactation: Not yet clear. Precautions for the elderly: Not yet clear.
Drug Interactions
-Atropine: can partially counteract the antihypertensive effect of Apocynum venetum leaves. -Diphenhydramine: can block the antihypertensive effect of Apocynum venetum leaves by more than 50%. Other antihypertensive drugs: Apocynum venetum can be used in combination with external Chinese medicine patches such as Li's Medicinal Patch, Jiangya Shen Patch, and Xuanya Patch to enhance the antihypertensive effect. For other drug interactions, please consult your doctor or pharmacist.
Storage
Keep tightly closed.
Packaging Specification
Compound
Validity Period
24 months
Manufacturer
Guangdong Heping Pharmaceutical Co., Ltd.
-
Founded in:
2002-09-10 -
Address:
No. 21 Shanhu Road, Heping County, Guangdong -
Tax NO.:
91441624742971842K -
Registered Funds:
17.5 million yuan -
Email: