Amoxicillin Sodium and Sulbactam Sodium for Injection

It is a thioxanthene derivative with a strong dopamine receptor blocking effect. In addition to blocking D1 and D2 receptors, it can also inhibit D2 autoreceptors and increase the DA concentration between synapses. It has no sedative effect. Its antipsychotic effect is 4 to 8 times stronger than that of Telden. In addition, it also has antidepressant and antianxiety effects.

Flupenthixol dihydrochloride

This product is white to yellow powder.

The effect is stronger than that of aminosulfone thiothioxanthene. It can be used for acute and chronic schizophrenia. Its decanoate is a long-acting agent. It is suitable for negative symptoms of schizophrenia such as apathy and withdrawal, and also has a certain effect on those with anxiety and lack of motivation. Its decanoate long-acting preparation is often used for the maintenance treatment of chronic schizophrenia patients. 533 cases were reported abroad, with a significant efficacy of 41% to 55%. Shanghai Mental Health Center treated 60 chronic patients with a course of more than 5 years, and found that 25 cases (41.7%) had moderate efficacy or above after 3 months of treatment.

The usual dose is 1 mg twice a day, with an increase of 500 μg each time, up to a maximum of 3 mg per day. The dosage can be reduced for the elderly.

Extrapyramidal symptoms are common. They are mainly extrapyramidal reactions, with occasional transient insomnia. Long-term use of the drug may cause tardive dyskinesia.

1. Patients allergic to penicillin or other β-lactam antibiotics are contraindicated. 2. Patients allergic to sulbactam are contraindicated.

Precautions for children: Most penicillins have been used in pediatric patients and no special problems have been found so far. Incomplete renal development in newborns and infants under 6 months of age may slow the excretion of penicillin through the urinary tract. Precautions for pregnancy and lactation: Pregnancy: There are no appropriate and well-controlled human studies to date. Penicillin should be used in pregnant women only when the benefits outweigh the risks. However, penicillin use during pregnancy has not been shown to have toxic effects on the fetus. Breastfeeding mothers: Penicillin can be secreted in human milk. Although no major problems have been seen so far, penicillin use by breastfeeding mothers may cause susceptibility, diarrhea, candidiasis, and rash in infants. Precautions for the elderly: Penicillin has been used in elderly patients and no special problems have been found so far. However, since the elderly are prone to age-related renal failure, dose adjustment is necessary.

Large doses can increase the effects of ethanol, barbiturates and other central nervous system depressants. It can block the antihypertensive effect of guanethidine and weaken the effects of levodopa and adrenaline. Combination with metoclopramide and piperazine can increase the occurrence of extrapyramidal symptoms.

Sealed storage

0.75 g (2:1)

24 months