Cefixime Granules (Dalifen)
Function and Efficacy
1. Antibacterial effect This product has antibacterial activity against some Gram-positive and Gram-negative bacteria and is a broad-spectrum antibiotic. In particular, it has a stronger antibacterial effect than other oral cephalosporin antibiotics against streptococci (except enterococci) and pneumococci among Gram-positive bacteria, and gonococci, Branhamella, Escherichia coli, Clostridium, Salivarius, Proteus, and Haemophilus influenzae among Gram-negative bacteria, and its mechanism of action is bactericidal. It has extremely strong stability against β-lactamases produced by various bacteria and shows superior antibacterial power against bacteria that produce β-lactamases. 2. Mechanism of action The mechanism of action is to prevent the synthesis of bacterial cell walls. Its point of action varies depending on the species, and it has a higher affinity with 1 (1a, 1b, 1c) and 3 in penicillin-binding protein (PBP).
Ingredients
Cefixime trihydrate.
| Name | Description | Content | CAS NO. | Manufacturer |
|---|---|---|---|---|
| YTTERBIUM(III) IONOPHORE IIngredients |
It has antibacterial activity against some Gram-positive and Gram-negative bacteria and is a broad-spectrum antibiotic. In particular, it has a stronger antibacterial effect than other oral cephalosporin antibiotics against Streptococcus (except enterococci) and pneumococci among Gram-positive bacteria, and against gonococci, Branhamella, Escherichia coli, Clostridium, Saccharomyces, Proteus, and Haemophilus influenzae among Gram-negative bacteria. Its mechanism of action is bactericidal. It has extremely strong stability against β-lactamases produced by various bacteria and shows superior antibacterial activity against bacteria that produce β-lactamases. The mechanism of action is to prevent the synthesis of bacterial cell walls. Its point of action varies depending on the species, and it has a higher affinity with 1 (1a, 1b, 1c) and 3 in penicillin-binding protein (PBP). More |
125110-14-7 | 1 |
Appearance
This product is a suspension granule with a fragrant aroma and sweet taste.
Indication
It is effective for the following infections caused by cefixime-sensitive bacteria among Streptococcus (except enterococci), Pneumococcus, Neisseria gonorrhoeae, Branhamella catarrhalis, Escherichia coli, Klebsiella, Serratia, Proteus, and Haemophilus influenzae. Bronchitis, bronchiectasis (infection), secondary infection of chronic respiratory infections, pneumonia, pyelonephritis, cystitis, gonococcal urethritis; cholecystitis, cholangitis, scarlet fever; otitis media, sinusitis.
Usage and Dosage
Usually used for oral administration in children. 1.5-3.0 mg/kg per time, twice a day. In addition, the dosage can be increased or decreased appropriately according to the symptoms. For severe cases or cases with no obvious effect, 6 mg/kg per time, twice a day.
Adverse Reactions
Among the total 12,879 cases, adverse reactions including abnormal clinical examination values were found in 294 cases (2.58%). These adverse reactions included 112 cases (0.87%) of gastrointestinal symptoms such as diarrhea, 29 cases (0.23%) of skin symptoms such as rash, and abnormal clinical examination values including 78 cases (0.61%) of increased GPT, 58 cases (0.45%) of increased GOT, 26 cases (0.20%) of eosinophilia, etc. Serious adverse reactions: 1. Shock: Due to the possibility of causing shock (0.1%), close observation should be made. If discomfort, abnormal sensation in the mouth, asthma, dizziness, urge to defecate, tinnitus, sweating, etc. occur, the drug should be stopped and appropriate treatment should be taken. 2. Allergic-like symptoms: If there are
Precautions
Patients who are allergic to this product or cephalosporin antibiotics are contraindicated.
Special Population Medication
Precautions for children: Use with caution in newborns and premature infants. Precautions for pregnancy and lactation: Use with caution in pregnant and lactating women. Precautions for the elderly: Use with caution in elderly patients.
Drug Interactions
1. This product is contraindicated with the following drugs: Amikacin sulfate, gentamicin, kanamycin, tobramycin. Neomycin, chlortetracycline hydrochloride, tetracycline hydrochloride, oxytetracycline hydrochloride, colistin sodium methanesulfonate, polymyxin B sulfate, erythromycin gluconate, erythromycin lactobionate, lincomycin, sulfisoxazole, aminophylline, soluble barbiturates, calcium chloride, calcium gluconate, other antihistamines such as diphenhydramine hydrochloride, lidocaine, norepinephrine, metaraminol, methylphenidate, succinylcholine, etc. Occasionally, it may also be contraindicated with the following drugs: penicillin, methicillin, hydrocortisone succinate, phenytoin sodium. Prochlorperazine, B vitamins and vitamin C, hydrolyzed protein. 2. Furosemide, ethacrynic acid, bumetamol
Storage
Seal and store in a cool dark place (avoid light and not exceed 20℃).
Packaging Specification
50 mg (sugar-free) based on 2 tablets of C16H15N507
Validity Period
30 months.
Manufacturer
Sinopharm ZHIJUN(Shenzhen)PHARMACEUTICAL Co., Ltd.
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Founded in:
1985-12-11 -
Address:
No. 16, Lanqing 1st Road, Guanlan High-tech Park, Longhua New District, Shenzhen -
Tax NO.:
91440300192190290M -
Registered Funds:
200 million yuan -
Website:
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Email: