Levamisole Hydrochloride Suppository

This product is the levorotatory form of tetramisole, which can selectively inhibit succinate dehydrogenase in the muscles of the worm, so that fumaric acid cannot be reduced to succinic acid, thereby affecting the anaerobic metabolism of the muscles of the worm and reducing energy production. When the worm comes into contact with it, it can depolarize the nerves and muscles, and the muscles will continue to contract and cause paralysis; the drug's cholinergic effect is conducive to the excretion of the worm. Its activity is about 1 to 2 times that of tetramisole (racemic form), but its toxic side effects are lower. In addition, the drug may have an inhibitory effect on the microtubule structure of the worm. Levamisole also has immune regulation and immune excitation functions.

Main ingredient: Levamisole hydrochloride Chemical name: (S)-(-)-6-phenyl-2,3,5,6-tetrahydroimidazo[2,1-b]thiazole hydrochloride.

This product is a milky white or slightly yellow suppository.

Used to expel ascaris, hookworms, pinworms and strongyloides, etc.

Rectal administration for pinworm and ascariasis: 50 mg for children under 1 year old, 75 mg for children under 3 years old, 100 mg for children under 5 years old, 150 mg for children under 10 years old, 1 tablet once a day, 3 consecutive days as a course of treatment. For hookworm disease, 25 mg for children aged 1-4 years old, 50 mg for children aged 5-12 years old, and 100 mg for children aged 13-15 years old, 1 tablet once a day, 3 consecutive days as a course of treatment.

Generally mild. Symptoms include nausea, vomiting, abdominal pain, etc. A few may experience taste disorders, fatigue, dizziness, headache, joint pain, confusion, insomnia, fever, flu-like symptoms, low blood pressure, vasculitis, rash, photosensitivity dermatitis, etc. Proteinuria is occasionally seen. Some may have granulocytopenia and thrombocytopenia. A few may even have agranulocytosis (often reversible), which often occurs in patients with rheumatism or tumors. In addition, it can cause immediate and Arthus allergic reactions, which may be atopic reactions caused by stimulating T cells. Individual cases may experience ataxia, paresthesia, or blurred vision.

It is contraindicated for patients with impaired liver and kidney function, active hepatitis, early pregnancy, or pre-existing schistosomiasis.

Precautions for children: Not yet clear. Precautions for pregnancy and lactation: Not yet clear. Precautions for the elderly: Not yet clear.

1. Combined with pyrantel, it can treat severe hookworm infection and improve the effect of expelling American hookworm. 2. Combined with thiabendazole, it can treat mixed intestinal nematode infection. 3. Sequential use with diethylcarbamazine citrate can treat filarial infection. 4. It should not be used in combination with tetrachloroethylene to avoid increasing its toxicity.

Keep tightly closed in a cool place.

0.1g

24 months

Shanxi Dayin Children's Pharmaceutical Co., Ltd.

• Founded in:

  2015-12-14

• Address:

  No. 20 Huagong Road, Jinyuan District

• Tax NO.:

  91140100MA0GRM9W8E

• Registered Funds:

  50 million yuan

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