Ciprofloxacin Hydrochloride Tablets

This product has a broad-spectrum antibacterial effect, especially high antibacterial activity against aerobic Gram-negative bacilli. It has good antibacterial activity in vitro against the following bacteria: most bacteria of the Enterobacteriaceae family, including Citrobacter, cloacae, Enterobacter aerogenes, Escherichia coli, Klebsiella, Proteus, Salmonella, Shigella, Vibrio, Yersinia, etc. It often has antibacterial activity against multi-drug resistant bacteria. It has high antibacterial activity against penicillin-resistant Neisseria gonorrhoeae, enzyme-producing Haemophilus influenzae and Moraxella. It has antibacterial activity against most strains of Pseudomonas such as Pseudomonas aeruginosa. This product has antibacterial activity against methicillin-sensitive Staphylococcus, and only moderate antibacterial activity against Streptococcus pneumoniae, hemolytic Streptococcus and Enterococcus faecalis. It also has good effects on Chlamydia trachomatis, Mycoplasma, Legionella, and antibacterial activity against Mycobacterium tuberculosis and atypical mycobacteria. Poor antibacterial activity against anaerobic bacteria. Ciprofloxacin is a bactericide that acts on the A subunit of bacterial DNA gyrase, inhibiting DNA synthesis and replication, leading to bacterial death.

Ciprofloxacin hydrochloride

This product is white or off-white tablets or film-coated tablets, which appear white or off-white after removing the coating.

Respiratory tract infections caused by sensitive bacteria such as pneumonia, bronchopneumonia, infectious pleurisy, empyema, lung abscess, infectious bronchiectasis, acute exacerbation of chronic bronchitis, and lung infections in patients with cystic fibrosis. Urinary tract infections such as acute and chronic pyelonephritis, prostatitis, cystitis, epididymitis, and chronic recurrent urinary tract infections. Ear, nose, and throat infections: such as otitis media, sinusitis, and mastoiditis. Gonorrhea: including gonorrheal urethral, rectal, and pharyngeal infections, as well as infections caused by drug-resistant gonococci. Skin and soft tissue infections such as infected ulcers, wound infections, abscesses, cellulitis, otitis externa, and post-burn infections. Intra-abdominal infections such as peritonitis, intra-abdominal abscesses, cholangitis, cholecystitis, and gallbladder empyema. Gynecological infections such as salpingitis, endometritis, and pelvic inflammatory disease. Bone joints

Oral. 1 Common dosage for adults: 0.5-1.5g per day, divided into 2-3 times. 2 Bone and joint infections: 1-1.5g per day, divided into 2-3 times, the course of treatment is 4-6 weeks or longer. 3 Pneumonia and skin and soft tissue infections: 1-1.5g per day, divided into 2-3 times, the course of treatment is 7-14 days. 4 Intestinal infections: 1g per day, divided into 2 times, the course of treatment is 5-7 days. 5 Typhoid fever: 1.5g per day, divided into 2-3 times, the course of treatment is 10-14 days. 6 Urinary tract infection: Acute simple lower urinary tract infection, 0.5g per day, divided into 2 times, the course of treatment is 5-7 days; complicated urinary tract infection, 1g per day, divided into 2 times, the course of treatment is 7-14 days. 7 Simple gonorrhea: single oral administration of 0.5g.

1 Gastrointestinal reactions are relatively common and may manifest as abdominal discomfort or pain, diarrhea, nausea or vomiting. 2 Central nervous system reactions may include dizziness, headache, drowsiness or insomnia. 3 Allergic reactions: rash, skin itching, and occasionally exudative erythema multiforme and angioedema. A small number of patients have photosensitivity reactions. 4 Occasionally, the following may occur: (1) epileptic seizures, mental abnormalities, irritability, confusion, hallucinations, and tremors. (2) Manifestations of interstitial nephritis such as hematuria, fever, and rash. (3) Crystalluria, which is more common when used in high doses. (4) Joint pain. 5 A small number of patients may experience elevated serum aminotransferases, elevated blood urea nitrogen, and decreased peripheral white blood cells, which are mostly mild and transient.

Patients who are allergic to ciprofloxacin or quinolone derivatives, children under 12 years old. Patients with central nervous system diseases such as severe cerebral arteriosclerosis and epilepsy should use with caution. Patients with severe renal impairment (creatinine clearance is less than or equal to 20mL/min) should reduce the dosage by half. This drug should be avoided from being used simultaneously with antacids, and you should drink plenty of water when taking it. Effects on pregnancy and lactation Studies on the use of this drug in pregnant women have not yet reached a clear conclusion, but since this drug can cause joint lesions in minor animals, it should be used with caution in pregnant and lactating women.

Precautions for children: The safety of this product in infants and adolescents under 18 years of age has not been determined. However, this product can cause joint lesions when used in several young animals. Therefore, it should not be used in children and adolescents under 18 years of age. Precautions for pregnancy and lactation: Animal experiments have not confirmed that quinolones are teratogenic, but studies on the use of drugs in pregnant women have not yet reached a clear conclusion. Since this drug can cause joint lesions in underage animals, it is contraindicated for pregnant women, and lactating women should suspend breastfeeding when using this product. Precautions for the elderly: Elderly patients often have impaired renal function, and since this product is partially excreted through the kidneys, it needs to be used in reduced doses.

1 Urine alkalinizing drugs can reduce the solubility of this product in urine, leading to crystalluria and nephrotoxicity. 2 Acid-reducing drugs containing aluminum or magnesium can reduce the oral absorption of this product, and it is recommended to avoid co-use. If it cannot be avoided, it should be taken 2 hours before taking this product, or 6 hours after taking the medicine. 3 When this product is used in combination with theophylline, competitive inhibition of the binding site of cytochrome P450 may lead to a significant reduction in the liver elimination of theophylline, prolonged blood elimination half-life (t1/2beta;), increased blood drug concentration, and symptoms of theophylline poisoning, such as nausea, vomiting, tremor, restlessness, excitement, convulsions, palpitations, etc. Therefore, theophylline blood drug concentration should be measured and the dose adjusted when used in combination. 4 When cyclosporine is used in combination with this product, its blood drug concentration increases, and the blood concentration of cyclosporine must be monitored and the dose adjusted. 5 When this product is used in combination with the anticoagulant warfarin, it can enhance the anticoagulant effect of the latter. When used in combination, the patient's prothrombin time should be closely monitored. 6. Probenecid can reduce the secretion of this product from the renal tubules by about 50%. When used together, it may cause toxicity due to the increased blood concentration of this product. 7. This product interferes with the metabolism of caffeine, resulting in reduced caffeine elimination, prolonged blood elimination half-life (t1/2beta;), and may cause central nervous system toxicity. 8. Didanosine (DDI) drugs can reduce the oral absorption of this product. Because the aluminum and magnesium contained in its preparations can chelate with this product, it is not suitable for use together.

Store in a cool place away from light

Calculated as ciprofloxacin 0.25g

24 months.

Chongqing KERUI Pharmaceutical (GROUP) Co., Ltd.

• Founded in:

  1999-03-03

• Address:

  No. 2 Dashizhi Road, Nan'an Economic and Technological Development Zone, Chongqing

• Tax NO.:

  915001082031636780

• Registered Funds:

  110.6375 million yuan

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