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Low molecular weight dextran amino acid injection

Function and Efficacy

This product is a nutritional blood volume expander. After intravenous injection, it can increase plasma colloidal osmotic pressure, absorb extravascular water to increase blood volume, and increase and maintain blood pressure. Its blood volume expansion effect is weaker and shorter than that of dextran 70, but its effect on improving microcirculation is stronger than that of dextran 70. It can disaggregate already aggregated red blood cells and platelets, reduce blood viscosity, improve microcirculation, and prevent thrombosis. In addition, it also has an osmotic diuretic effect, and this product has strong antigenicity. Since there are bacteria that produce this product in the normal intestine, some patients will have allergic reactions even after the first injection of this product. It is mainly an allergic reaction of the skin and mucous membranes. It can supplement the body's essential amino acids, significantly increase protein synthesis and improve nutritional status. It has the effects of promoting normal protein metabolism in the human body, correcting negative nitrogen balance, supplementing protein, and accelerating wound healing.

Ingredients

This product is a colorless or slightly yellowish, slightly viscous, clear sterile solution containing 6% low molecular weight dextran (average molecular weight of about M40,000) and 11 kinds of amino acids, containing 2.72% of total amino acids. Each 1ml contains 60mg of dextran, 2.72mg of total amino acids, and 4.2mg of effective nitrogen. The electrolyte concentration of this product is about 7mmol/L potassium ion and about 53mmol/L chloride ion. The pH value is 5.0-7.0. The osmotic pressure is about 300mOsm/L.

Name Description Content CAS NO. Manufacturer
DextranIngredients

Expand blood volume, improve microcirculation, prevent thrombosis, osmotic diuretic effect

More
9004-54-0 16
L-tert-LeucineIngredients

Supplement essential amino acids, promote normal protein metabolism, correct negative nitrogen balance, supplement protein, and accelerate wound healing

More
20859-02-3 0

Appearance

This product is a colorless or slightly yellowish, slightly viscous clear liquid, sometimes showing a slight opalescence.

Indication

It is used for various shock and thrombotic diseases. It can also be used for limb replantation and vascular surgery to prevent postoperative thrombosis.

Usage and Dosage

Intravenous drip, 500 ml at a time, once a day, can be used continuously for 4 to 5 days or as directed by the doctor.

Adverse Reactions

1. A small number of patients may experience allergic reactions, manifested as skin itching, urticaria, nausea, vomiting, asthma, cyanosis of the lips, collapse, a sharp drop in blood pressure, bronchospasm in severe cases, and some patients may even experience anaphylactic shock and even death. The incidence of allergic reactions is about 0.03% to 4.7%. People with allergic constitutions should undergo a skin test before use. 2. Fever, chills, swollen lymph nodes, arthritis, etc. are occasionally seen. 3. Bleeding tendency can cause coagulation disorders and prolong bleeding time. This reaction is often related to the dose. 4. Too fast an infusion rate can cause nausea, vomiting, headache and asthma.

Precautions

It is contraindicated for patients with congestive heart failure and severe bleeding diseases. It is contraindicated for those who are allergic to this product.

Special Population Medication

Precautions for children: Not yet clear. Precautions for pregnancy and lactation: Do not use it together with painkillers or epidural anesthesia during childbirth for prevention or treatment. If the mother is allergic to dextran or has an anaphylactic reaction, it may cause excessive uterine tension and fetal hypoxia. There is a risk of death or serious consequences to the infant's nervous system. Precautions for the elderly: Not yet clear.

Drug Interactions

1. When used in combination with heparin, the possibility of bleeding increases due to synergistic effects. 2. When used in combination with gentamicin and paromomycin, nephrotoxicity increases.

Storage

Keep tightly closed in a cool, dark and dry place.

Packaging Specification

250 ml contains 6.0% low molecular weight dextran and 2.72% total amino acids

Validity Period

Tentative 24 months

Manufacturer

Livzon Pharmaceutical Grouping Limin Pharmaceutical FACTORY

  • Founded in:

    1997-05-24
  • Address:

    No. 89, Gongye West Road, Shaoguan City, Guangdong
  • Tax NO.:

    91440200618357941C
  • Registered Funds:

    61.56101 million yuan
  • Email:

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