Diclofenac Sodium Sustained Release Capsules

Pharmacological action: Diclofenac sodium is a non-steroidal anti-inflammatory analgesic derived from phenylacetic acid. Its mechanism of action is to inhibit the activity of cyclooxygenase, thereby blocking the conversion of arachidonic acid to prostaglandins. At the same time, it can also promote the combination of arachidonic acid and triglycerides, reduce the concentration of free arachidonic acid in cells, and indirectly inhibit the synthesis of leukotrienes. Diclofenac sodium is a stronger non-steroidal anti-inflammatory drug. Its inhibitory effect on prostaglandin synthesis is stronger than that of aspirin and indomethacin.

The main ingredient of this product is: diclofenac sodium.

This product is a capsule, and the contents are off-white to light yellow spherical micro-pellets.

① Relieve acute attacks or persistent joint swelling and pain in rheumatoid arthritis, osteoarthritis, spondyloarthropathies, gouty arthritis, rheumatoid arthritis and other chronic arthritis; ② Various soft tissue rheumatic pains, such as shoulder pain, tenosynovitis, bursitis, myalgia and pain after sports injuries; ③ Acute mild and moderate pains, such as pain after surgery, trauma, strain, primary dysmenorrhea, toothache, headache, etc.

Oral administration: This product should be swallowed whole without chewing. 100 mg (1 tablet) once a day, or as directed by a doctor.

1 Gastrointestinal reactions: The most common adverse reactions include stomach discomfort, abdominal pain, burning sensation, acid reflux, poor appetite, nausea and constipation, etc. A few patients may experience ulcers, bleeding, and perforation. 2 Nervous system manifestations include headache, dizziness, drowsiness, excitement, etc. 3 It may cause serious adverse reactions such as edema, oliguria, and electrolyte imbalance. 4 Other rare adverse reactions include transient increase in serum transaminase, and very few patients may experience jaundice, rash, arrhythmia, granulocytopenia, thrombocytopenia, etc.

It is contraindicated for patients who are allergic to this product or other non-steroidal anti-inflammatory drugs.

Precautions for children: This product is not recommended for children under 14 years old. Precautions for pregnancy and lactation: This product can cross the placenta. Animal experiments showed toxicity to fetal mice, but it was not teratogenic. It is forbidden for pregnant and lactating women. Precautions for the elderly: This product can cause or aggravate gastrointestinal bleeding, gastric ulcers and perforations in the elderly, so use with caution.

1. Drinking alcohol or taking it with other non-steroidal anti-inflammatory drugs will increase gastrointestinal adverse reactions and the risk of ulcers. Long-term use with acetaminophen may increase the toxic side effects on the kidneys. 2. When used with anticoagulants such as heparin and dicoumarol and platelet aggregation inhibitors, there is an increased risk of bleeding. 3. When used with furosemide, the latter's sodium excretion and antihypertensive effects are weakened. 4. When used with verapamil and nifedipine, the blood concentration of this product increases. 5. This product can increase the blood concentration of digoxin, so it is necessary to pay attention to adjusting the dose of digoxin when used together. 6. When this product is used with antidiabetic drugs, it can affect the efficacy of the latter, so it needs to be considered carefully. 7. When this product is used with antihypertensive drugs, it can affect the antihypertensive effect of the latter. 8. Probenecid can reduce the excretion of this product, increase the blood concentration, and thus increase the toxicity, so it is advisable to reduce the dose of this product when used together. 9 This product can reduce the excretion of methotrexate and increase its blood concentration, even to toxic levels, so this product should not be used with medium or large doses of methotrexate. 10 It can cause hyperkalemia when used with potassium-sparing diuretics.

Store sealed in a dry place away from light.

50mg

24 months

Nanjing CHANG AO Pharmaceutical Co., Ltd.

• Founded in:

  1997-08-13

• Address:

  No. 63, Kexin Road, Jiangbei New District, Nanjing

• Tax NO.:

  91320100634081762H

• Registered Funds:

  $46.83 million

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