Simvastatin Capsules

This product itself is inactive. The hydrolysis product after oral absorption competitively inhibits the rate-limiting enzyme hydroxymethylglutaryl coenzyme A reductase in the cholesterol synthesis process in the body, reducing the synthesis of cholesterol and increasing the synthesis of low-density lipoprotein receptors. The main site of action is in the liver, resulting in lower blood cholesterol and low-density lipoprotein cholesterol levels, moderately lower serum triglyceride levels and increased blood high-density lipoprotein levels. This has an effect on the prevention and treatment of atherosclerosis and coronary heart disease. In mice, 3-4 times the human dose can cause cancer, but no increase in tumor occurrence has been observed in large-scale long-term clinical trials in humans. Existing studies have not found that this product has a mutagenic effect.

The main ingredient of this product is simvastatin

This product is a capsule with white or off-white contents.

Used for the treatment of hypercholesterolemia and combined hyperlipidemia; prevention and treatment of coronary heart disease and cerebral stroke.

The usual oral dose for adults is 10-20 mg, once a day, taken at dinner. The dose can be adjusted as needed, but the maximum dose should not exceed 80 mg per day.

1 The most common adverse reaction of this product is gastrointestinal discomfort, and others include headache, rash, dizziness, blurred vision and taste disturbance. 2 It may occasionally cause a reversible increase in blood aminotransferase. Therefore, liver function needs to be monitored. 3 Rare adverse reactions include impotence and insomnia. 4 Rare adverse reactions include myositis, myalgia, and rhabdomyolysis, which are manifested as muscle pain, fatigue, fever, and are accompanied by increased blood creatine phosphokinase, myoglobinuria, etc. Rhabdomyolysis can lead to renal failure, but it is rare. The combination of this product with immunosuppressants, folic acid derivatives, niacin, gemfibrozil, erythromycin, etc. can increase the risk of myopathy. 5 Hepatitis, pancreatitis and allergic reactions such as angioedema have been reported.

1. Patients who are allergic to simvastatin should not use this drug. Patients who are allergic to other HMG-CoA reductase inhibitors should use this drug with caution. 2. Patients with active liver disease or unexplained persistent elevation of blood aminotransferase should not use this drug.

Precautions for children: The safety and effectiveness of simvastatin for children have not been determined. Simvastatin is not currently recommended for children. Precautions for pregnancy and lactation: Because this product can cause fetal maldevelopment in animal experiments and it is unclear whether it is excreted in breast milk, it is not recommended for use in pregnant women and nursing mothers. Precautions for the elderly: In controlled clinical trials of simvastatin in elderly patients (over 65 years old), its effect on lowering total cholesterol and low-density lipoprotein (LDL) cholesterol was the same as that of other populations, and the frequency of adverse reactions and laboratory test abnormalities did not increase significantly.

1. The combination of this product with oral anticoagulants can prolong the prothrombin time and increase the risk of bleeding. 2. The combination of this product with immunosuppressants such as cyclosporine, erythromycin, gemfibrozil, niacin, etc. can increase the risk of myolysis and acute renal failure. 3. Colestipol and cholestyramine can reduce the bioavailability of this product, so this product should be taken 4 hours after taking the former.

Keep in a light-proof and airtight container.

5 mg

24 months

Shandong Lukang Pharmaceutical Co., Ltd.

• Founded in:

  1993-02-15

• Address:

  No. 88, Deyuan Road, Jining High-tech Zone, Shandong Province

• Tax NO.:

  913700001659297311

• Registered Funds:

  880.229735 yuan

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