Cisapride Tablets

This product is a whole gastrointestinal tract motility drug, which can enhance esophageal peristalsis and lower esophageal sphincter tension, prevent gastric contents from reflux into the esophagus, and improve esophageal clearance; increase gastric and duodenal contractility and coordination of gastric antrum and duodenum; reduce duodenal and gastric reflux, improve gastric and duodenal emptying; strengthen intestinal movement and promote small and large intestine transit. This product does not increase the basal and pentagastrin-induced gastric acid secretion. In addition, it has almost no effect on plasma prolactin levels.

Main ingredients: The main ingredient of this product is cisapride. Its chemical name is cis-4-amino-5-chloro-N-[1-[3-(4-fluorophenoxy)propyl]-3-methoxy-4-pyridyl]-2-methoxyaniline. Molecular formula: C23H29ClFN3O4 Molecular weight: 465.95

White tablets.

(1) Gastroparesis syndrome, or upper gastrointestinal discomfort, but with negative X-ray and endoscopy, characterized by early satiety, fullness after meals, decreased appetite, bloating, excessive belching, anorexia, nausea, vomiting or ulcer-like complaints (burning pain in the upper abdomen). (2) Gastroesophageal reflux, including the treatment and maintenance of esophagitis. (3) Pseudo-intestinal obstruction This product can improve insufficient peristalsis and gastrointestinal content retention. (4) Chronic constipation.

Oral administration, the total daily dose for adults is 15-40 mg, divided into 2-4 times, depending on the condition. 1 General condition: 5 mg once, 3 times a day; 2 Severe condition: (gastroparesis, esophagitis, stubborn constipation) 10 mg once, 3 times a day, or 10 mg once, 4 times a day, before three meals and before bedtime. Or 20 mg once, 2 times a day, before breakfast and before bedtime; 3 Maintenance treatment of esophagitis: 10 mg once, 2 times a day (before breakfast and before bedtime) or 20 mg once, 1 time a day (before bedtime), the dose can be doubled for severe cases; 4 For the treatment of upper gastrointestinal dysfunction, it should be taken at least 15 minutes before meals and at an appropriate time before bedtime with some drinks; 5 For the treatment of constipation, the total daily dose should be taken twice. There are large individual differences in dosage, number of doses per day, course of treatment, and whether maintenance treatment is needed (once a day is sufficient). Generally, symptoms can be improved within a week, but for patients with severe constipation, ideal treatment effects may take 2 to 3 months.

1 Occasionally, transient abdominal cramps, borborygmus, and diarrhea may occur, and the dose can be halved; 2 Occasionally, allergies, mild transient headaches or dizziness, and frequent urination related to the dose have been reported; 3 Rarely, reversible liver function abnormalities may occur, with or without cholestasis; 4 Male breast feminization and galactorrhea, the incidence in large-scale monitoring studies (<0.1%) does not exceed the common value of the general population, and is reversible after discontinuation of the drug. The causal relationship is not clear; 5 Rarely, it affects the central nervous system, namely, convulsive epilepsy, extrapyramidal reactions, and frequent urination.

1. Patients with known allergy to this product are prohibited from using this product; 2. Patients with gastrointestinal bleeding, obstruction or perforation.

Precautions for children: Premature infants less than 34 weeks of gestation should be used with caution. Precautions for pregnancy and lactation: 1. Although it does not affect embryo formation in animals, has no original embryo toxicity, and has no teratogenic effect, if it is used during pregnancy, especially in the first three months of pregnancy, the pros and cons should be weighed. 2. Although the amount excreted through breast milk is very small, it is still recommended that breastfeeding mothers do not use it. Precautions for the elderly: In the elderly, due to the moderate extension of the elimination half-life, the steady-state plasma concentration will generally increase, so the therapeutic dose should be reduced as appropriate.

1. This product is a strong inhibitor of CYP3A4, so it should not be used with drugs that are mainly metabolized by CYP3A4, such as imidazoles, macrolides, etc., to avoid serious adverse reactions; 2. This product can accelerate gastric emptying of drugs, reduce the absorption rate of drugs absorbed through the stomach, and increase the absorption rate of drugs absorbed through the intestines.

Store in a dry place at 15-30℃, out of reach of children.

10mg (calculated as C23H29ClFN3O4)

Zhejiang Jingxin Pharmaceutical Co., Ltd.

• Founded in:

  1999-02-13

• Address:

  No. 800, Xinchang Avenue East Road, Yulin Street, Xinchang County, Zhejiang Province

• Tax NO.:

  91330000704503984N

• Registered Funds:

  861.02914 million yuan

• Website:

  Log in to view

• Email:

  Log in to view