Levofloxacin Hydrochloride Tablets

This product is the levorotatory form of ofloxacin, and its antibacterial activity is about twice that of ofloxacin. Its main mechanism of action is to inhibit the activity of bacterial DNA gyrase (bacterial topoisomerase II) and hinder bacterial DNA replication. This product has the characteristics of a broad antibacterial spectrum and strong antibacterial effect. It has strong antibacterial activity against most Enterobacteriaceae, such as Escherichia coli, Klebsiella, Serratia, Proteus, Shigella, Salmonella, Citrobacter, Acinetobacter, as well as Gram-negative bacteria such as Pseudomonas aeruginosa, Haemophilus influenzae, and Neisseria gonorrhoeae. It also has good antibacterial effects on some methicillin-sensitive Staphylococci, Streptococcus pneumoniae, Streptococcus pyogenes, hemolytic Streptococcus, and Legionella, Mycoplasma, and Chlamydia, but has poor effects on anaerobic bacteria and enterococci.

Levofloxacin Hydrochloride

This product is an off-white or light yellow tablet or film-coated tablet, which appears white or light yellow after removing the film coating.

Applicable to infections caused by sensitive bacteria: 1. Urinary and reproductive system infections, including simple and complicated urinary tract infections, bacterial prostatitis, and urethritis caused by Neisseria gonorrhoeae. 2. Respiratory tract infections, including acute bronchial infections and lung infections caused by sensitive Gram-negative bacilli. 3. Gastrointestinal infections, caused by Shigella, Salmonella, enterotoxigenic Escherichia coli, Aeromonas aquaticus, Vibrio parahaemolyticus, etc. 4. Typhoid fever 5. Bone and joint infections 6. Skin and soft tissue infections 7. Systemic infections such as sepsis.

Adults take 0.2-0.3g per day, divided into 2-3 times orally, 1 tablet each time. For patients with more serious conditions, the maximum daily dose can be increased to 0.6g, divided into 3 times orally. In addition, the dose can be increased or decreased appropriately according to the type of infection and symptoms.

During medication, symptoms such as nausea, vomiting, abdominal discomfort, diarrhea, loss of appetite, abdominal pain, abdominal distension, insomnia, dizziness, headache and other neurological symptoms, as well as rash, itching and other symptoms may occur. Transient liver function abnormalities may also occur, such as increased serum transaminase and increased serum total bilirubin. The incidence of the above adverse reactions is between 0.1% and 5%. Occasionally, blood urea nitrogen rises, fatigue, fever, palpitations, abnormal taste, etc., which are generally tolerated and disappear quickly after the end of the treatment.

It is contraindicated for patients who are allergic to quinolones, pregnant and lactating women, and patients under 18 years of age.

Precautions for children: Patients under 18 years old are prohibited from using this product. Precautions for pregnancy and lactation: Precautions for pregnant and lactating women are prohibited from using this product. Precautions for the elderly: Elderly patients often have impaired renal function. Since this product is partially excreted through the kidneys, it needs to be used in a reduced dose.

When this product is used simultaneously with antacids containing magnesium or aluminum, sucralfate, metal cations (such as iron), and zinc-containing multivitamin preparations, it will interfere with the absorption of this product by the gastrointestinal tract, causing the concentration of this drug in various systems to be significantly reduced. Therefore, the time of taking the above-mentioned drugs should be at least 2 hours before or after using this product. Avoid using it simultaneously with theophylline. If it is necessary to use it simultaneously, the blood concentration of theophylline should be monitored and the dosage should be adjusted accordingly. When used simultaneously with warfarin or its derivatives, the prothrombin time or other coagulation tests should be monitored. When used simultaneously with non-steroidal anti-inflammatory drugs, there is a possibility of inducing convulsions. When used simultaneously with oral hypoglycemic drugs, it may cause blood sugar disorders, including hyperglycemia and hypoglycemia. Therefore, blood sugar concentrations should be monitored during medication. Once hypoglycemia occurs, this product should be discontinued immediately and appropriate treatment should be given.

Sealed and light-proof.

0.1g (as levofloxacin)

24 months

Guangdong P.D.Pharmaceutical Co., Ltd.

• Founded in:

  1994-08-15

• Address:

  No. 66, Bidi Avenue, Yueshan Town, Kaiping City, Guangdong Province

• Tax NO.:

  91440700617754849P

• Registered Funds:

  $6 million

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