Metronidazole tablets

This product is a nitroimidazole derivative that can inhibit the redox reaction of amoeba and break the nitrogen chain of the protozoa. In vitro tests have shown that when the drug concentration is 1-2 mg/L, the histolytica amoeba can undergo morphological changes in 6-20 hours and all are killed within 24 hours. When the concentration is 0.2 mg/L, the histolytica amoeba can be killed within 72 hours. This product has a strong effect of killing trichomonas, and its mechanism is unknown. Metronidazole has a killing effect on anaerobic microorganisms, and the metabolites generated when it is reduced in the human body also have anti-anaerobic effects, inhibiting the synthesis of bacterial deoxyribonucleic acid, thereby interfering with the growth and reproduction of bacteria, and ultimately causing bacterial death. It has a carcinogenic effect on some animals.

The main ingredient of this product is: Metronidazole. Its chemical name is: 2-methyl-5-nitroimidazole-1-ethanol. Molecular formula: C6H9N3O3 Molecular weight: 171.16

This product is white or off-white tablets.

It is used to treat intestinal and extraintestinal amebiasis (such as amoebic liver abscess, pleural amebiasis, etc.). It can also be used to treat vaginal trichomoniasis, balantidiasis, cutaneous leishmaniasis, guinea worm infection, etc. It is also widely used to treat anaerobic infections.

1 Common dosage for adults (1) Intestinal amebiasis: 0.4-0.6g once, 3 times a day, for a course of 7 days; extraintestinal amebiasis: 0.6-0.8g once, 3 times a day, for a course of 20 days. (2) Giardiasis: 0.4g once, 3 times a day, for a course of 5-10 days. (3) Guinea worm disease: 0.2g once, for a course of 7 days. (4) Balantidiasis: 0.2g once, 2 times a day, for a course of 5 days. (5) Cutaneous leishmaniasis: 0.2g once, 4 times a day, for a course of 10 days. Repeat the course of treatment after an interval of 10 days. (6) Trichomoniasis: 0.2g once, 4 times a day, for a course of 7 days; suppositories can be used at the same time, 0.5g inserted into the vagina every night, for 7-10 days. (7) For anaerobic infection, take orally 0.6-1.2g per day, divided into 3 times, for a course of 7-10 days. 2 Common dosage for children (1) For amebiasis, take orally 35-50mg/kg per day, divided into 3 times, for a course of 10 days. (2) For giardiasis, take orally 15-25mg/kg per day, divided into 3 times, for 10 consecutive days; the dosage for treating dracunculiasis, bagworm disease, and trichomoniasis is the same as that for giardiasis. (3) For anaerobic infection, take orally 20-50mg/kg per day, for a course of 10 days.

Adverse reactions occur in 15% to 30% of cases, with digestive tract reactions being the most common, including nausea, vomiting, loss of appetite, and abdominal cramps, which generally do not affect treatment; neurological symptoms include headache, dizziness, occasional paresthesia, limb numbness, ataxia, multiple neuritis, etc., and high doses can cause convulsions. A small number of cases develop urticaria, flushing, itching, cystitis, dysuria, metallic taste in the mouth, and leukopenia, all of which are reversible and recover on their own after stopping the drug.

It is contraindicated for patients with active central nervous system diseases and blood diseases.

Precautions for children: Not yet clear. Precautions for pregnancy and lactation: Not for use by pregnant and lactating women. Precautions for the elderly: Not yet clear.

This product can enhance the effect of anticoagulants such as warfarin. When used in combination with oxytetracycline, it can interfere with the effect of metronidazole in clearing vaginal Trichomonas.

Keep away from light and store in a sealed container.

0.2g

24 months

Shanghai Yuxin Biopharmaceutical Co., Ltd.

• Founded in:

  2004-02-06

• Address:

  No. 500, Guangming Road, Zhuangxing, Fengxian District, Shanghai

• Tax NO.:

  913101207584294339

• Registered Funds:

  90 million yuan

• Email:

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