Compound Cyclophosphamide Tablets

This product has no anti-tumor activity in vitro. After entering the body, it is first converted into aldehyde phosphoramide by microsomal functional oxidase in the liver. However, aldehyde phosphoramide is unstable and decomposes into phosphoramide nitrogen mustard and acrolein in tumor cells. Phosphoramide nitrogen mustard has cytotoxic effects on tumor cells. Cyclophosphamide is a bifunctional alkylating agent and a non-specific drug for the cell cycle. It can interfere with the functions of DNA and RNA, especially the former. It cross-links with DNA, inhibits DNA synthesis, and has the most obvious effect on the S phase.

This product is a compound preparation, its components are 50 mg of cyclophosphamide (C7H15Cl2N2O2PH2O) and 50 mg of total saponins from ginseng stems and leaves.

This product is enteric-coated tablets, which appear yellow or yellowish brown after removing the coating.

Anti-tumor drug. Mainly used for malignant lymphoma, acute lymphoblastic leukemia, lung cancer, various sarcomas, solid tumors and ovarian cancer.

Oral administration. Common adult dosage: 1 tablet at a time, 3 to 4 times a day.

1. Bone marrow suppression is the most common toxicity. White blood cells are often the lowest 10 to 14 days after administration, and usually return to normal on the 21st day. Thrombocytopenia is less common than other alkylating agents. Common side effects include nausea and vomiting. The severity is related to the dose. 2. The metabolites of cyclophosphamide can produce severe hemorrhagic cystitis, which can be avoided by large amounts of fluid supplementation. This product can also cause bladder fibrosis. 3. When a large dose of cyclophosphamide (50 mg/kg by body weight) is given at the same time as a large amount of fluid, water intoxication may occur, which can be prevented by giving furosemide at the same time. 4. Cyclophosphamide can cause reproductive system toxicity, such as amenorrhea or sperm deficiency, and administration in early pregnancy can cause teratogenesis. 5. Long-term administration of cyclophosphamide can produce secondary tumors. 6. Compound cyclophosphamide can alleviate severe immunosuppression. 7. When used for the treatment of leukemia or lymphoma, hyperuricemia and uric acid nephropathy are prone to occur. 8. Rare side effects include fever, allergies, skin and nail pigmentation, mucosal ulcers, increased alanine aminotransferase, urticaria, oropharyngeal paresthesia or blurred vision.

It is forbidden to use in pregnant and lactating women.

Precautions for children: This product has not been tested and there is no reliable reference. Precautions for pregnancy and lactation: Pregnant and lactating women are prohibited. Precautions for the elderly: This product has not been tested and there is no reliable reference.

1. Cyclophosphamide can increase serum uric acid levels. When used with anti-gout drugs such as allopurinol, colchicine, and probenecid, the dose of anti-gout drugs should be adjusted to control hyperuricemia and gout. Allopurinol can increase the bone marrow toxicity of cyclophosphamide. If it is necessary to use it together, its toxic effects should be closely observed. 2. When used with large doses of barbiturates, corticosteroids, or chloramphenicol, it can increase acute toxicity. 3. When used with doxorubicin, it can increase cardiac toxicity. The total dose of doxorubicin is not more than 400 mg/m3 based on body surface area. 4. It can inhibit cholinesterase to delay the metabolism of cocaine, prolong the effect of cocaine and increase toxicity. 5. Cyclophosphamide can reduce the concentration of pseudocholinesterase in plasma, enhance the neuromuscular blocking effect of succinylcholine, and prolong apnea.

Keep in a dark place, tightly sealed and store below 30℃.

Cyclophosphamide 50mg, total saponins from ginseng stems and leaves 50mg

24 months

Jilin Jiatai Pharmaceutical Co., Ltd.

• Founded in:

  2014-03-11

• Address:

  No. 8, Yongkang Road, Chaoyang Town, Huinan County, Jilin Province

• Tax NO.:

  912205233078719518

• Registered Funds:

  50 million yuan

• Email:

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