Colchicine Tablets

Colchicine changes the cell membrane function by: 1. binding to the subunit of neutrophil microtubule protein, including inhibiting the chemotaxis, adhesion and phagocytosis of neutrophils; 2. inhibiting phospholipase A2, reducing the release of prostaglandins and leukotrienes by monocytes and neutrophils; 3. inhibiting the production of interleukin-6 by local cells, thereby controlling the pain, swelling and inflammatory response of the joint. Colchicine does not affect the formation, dissolution and excretion of urate, so it has no effect on lowering blood uric acid. Acute gouty arthritis takes effect 12 to 24 hours after oral administration, and 90% of patients disappear from pain within 24 to 48 hours of taking the medicine. Acute toxicity test results: the intravenous LD50 of rats is 1.6 mg/kg; the intravenous LD50 of mice is 4.13 mg/kg.

The main ingredient of this product is colchicine, which is an alkaloid.

This product is white tablets.

Treat acute attacks of gouty arthritis and prevent recurrent acute attacks of gouty arthritis.

Oral acute phase: The usual dosage for adults is 0.5-1 mg every 1-2 hours until joint symptoms are relieved, or diarrhea or vomiting occurs. The therapeutic dosage is generally 3-5 mg, and it should not exceed 6 mg within 24 hours. After stopping for 72 hours, the daily dosage is 0.5-1.5 mg, taken in divided doses, for a total of 7 days. Prevention: 0.5-1.0 mg per day, taken in divided doses, but the course of treatment is determined at discretion. If adverse reactions occur, the drug should be discontinued at any time.

It is significantly correlated with the dosage, and oral administration is safer than intravenous injection. 1 Gastrointestinal symptoms: abdominal pain, diarrhea, vomiting and loss of appetite are common early adverse reactions, with an incidence of up to 80%. In severe cases, dehydration and electrolyte imbalance may occur. Long-term users may develop severe hemorrhagic gastroenteritis or malabsorption syndrome. 2 Muscle and peripheral neuropathy: There is proximal muscle weakness and (or) increased serum creatine phosphokinase. At the same time as muscle cell damage, peripheral nerve axonal polyneuropathy may occur, manifested as numbness, tingling and weakness. Muscle neuropathy is not common, often occurring in long-term users for gout prevention and those with mild renal insufficiency. 3 Bone marrow suppression: thrombocytopenia, neutrophil decrease, and even aplastic anemia occur, which can sometimes be life-threatening. 4 Shock: manifested as oliguria, hematuria, convulsions and impaired consciousness. The mortality rate is high, and it is more common in the elderly. 5 Teratogenicity: The fathers of two Down syndrome infants reported in the literature were both those who had a history of long-term use of colchicine due to familial Mediterranean fever. 6Others: hair loss, rash, fever and liver damage, etc.

It is contraindicated for patients with hypoplastic bone marrow, renal or hepatic dysfunction.

Precautions for children: Not clear yet. Precautions for pregnancy and lactation: This product can cause teratogenesis and is contraindicated for pregnant and lactating women. Precautions for the elderly: The dose should be reduced for the elderly. Because the toxic dose of this product is often related to its accumulated dose in the body, it is easy to cause cumulative poisoning when the renal excretion function decreases. This product also needs to be detoxified through the enterohepatic circulation. When the liver function is poor, the detoxification ability decreases, which can also easily lead to increased toxicity.

1. This product can cause reversible vitamin B12 malabsorption. 2. This product can enhance the efficacy of central nervous system depressants and the responsiveness of sympathomimetic drugs.

Sealed storage

0.5 mg

24 months

Jilin Province Overseas Chinese Pharmaceutical Group Co., Ltd.

• Founded in:

  2004-03-23

• Address:

  No. 2499, Qingnian Street, Songyuan City, Jilin Province

• Tax NO.:

  9122070175363135X6

• Registered Funds:

  50 million yuan

• Email:

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