Sodium Chloride Injection

Sodium chloride is an electrolyte supplement. Sodium and chloride are important electrolytes in the body, mainly present in extracellular fluid, and play a very important role in maintaining normal blood and extracellular fluid volume and osmotic pressure. The normal serum sodium concentration is 135-145mmol/L, accounting for 92% of plasma cations and 90% of total osmotic pressure, so the plasma sodium content plays a decisive role in osmotic pressure. The normal serum chloride concentration is 98-106mmol/L. Sodium and chloride ions in the human body are mainly regulated by the hypothalamus, posterior pituitary and kidneys to maintain the stability of body fluid volume and osmotic pressure.

Sodium chloride

This product is a colorless, clear liquid with a salty taste.

Dehydration caused by various reasons, including hypotonic, isotonic and hypertonic dehydration; hyperosmotic non-ketotic diabetic coma, the use of isotonic or hypotonic sodium chloride can correct dehydration and hypertonic state; hypochloremic metabolic alkalosis; external use of normal saline to rinse eyes, wash wounds, etc.; also used for obstetric water bag induction of labor

In severe hypotonic water loss, the solutes in brain cells decrease to maintain cell volume. If the treatment causes the plasma and extracellular fluid sodium concentration and osmotic concentration to rise rapidly, brain cell damage may occur. It is generally believed that when blood sodium is lower than 120mmol/L, the treatment causes the blood sodium to rise at a rate of 0.5mmol/L per hour, and should not exceed 1.5mmol/L per hour. When blood sodium is lower than 120mmol/L or central nervous system symptoms occur, 3% to 5% sodium chloride injection can be given by slow drip. It is generally required to increase the blood sodium concentration to above 120mmol/L within 6 hours. Sodium supplementation (mmol) = [142-actual blood sodium concentration (mmol/L)] × body weight (kg) × 0.2. When blood sodium rises to above 120-125mmol/L, isotonic solution can be used instead, or hypertonic glucose injection or 10% sodium chloride injection can be added to the isotonic solution as appropriate.

1. Too much or too fast infusion can cause water and sodium retention, resulting in edema, increased blood pressure, increased heart rate, chest tightness, dyspnea, and even acute left heart failure. 2. Too much or too fast administration of hypotonic sodium chloride can cause hemolysis, cerebral edema, etc.

Contraindicated in pregnancy induced hypertension.

When used as a drug solvent or diluent, attention should be paid to incompatibilities between drugs.

Keep tightly closed.

250ml:2.25g

PKU HealthCare Corp., Ltd.

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  1993-05-18

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