Lomefloxacin Hydrochloride Capsules

This product is a quinolone antibacterial drug. It has high antibacterial activity against Enterobacteriaceae such as Escherichia coli, Shigella, Klebsiella, Proteus, Enterobacter, etc.; Haemophilus influenzae and Neisseria gonorrhoeae are also highly sensitive to this product; it also has certain antibacterial effects on Pseudomonas such as Acinetobacter, Pseudomonas aeruginosa, Staphylococcus and Pneumococcus, hemolytic Streptococcus, etc. This product acts on the A subunit of DNA helicase in bacterial cells, inhibiting the synthesis and replication of DNA and exerting a bactericidal effect.

The main ingredient of this product is lomefloxacin hydrochloride. Its chemical name is (plusmn;)-ethyl-6,8-difluoro-1,4-dihydro-7-(3-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic acid hydrochloride. Molecular formula: C17H19F2N3O3HCl Molecular weight: 387.81

Capsules.

This product is suitable for the following infections caused by sensitive bacteria: 1. Respiratory tract infections: acute exacerbation of chronic bronchitis, bronchiectasis with infection, acute bronchitis and pneumonia, etc.; 2. Urogenital system infections: acute cystitis, acute pyelonephritis, complicated urinary tract infection, acute exacerbation of chronic urinary tract infection, acute and chronic prostatitis, and Neisseria gonorrhoeae urethritis or cervicitis (including those caused by enzyme-producing strains), etc.; 3. Gastrointestinal bacterial infections: caused by Shigella, Salmonella, enterotoxigenic Escherichia coli, Aeromonas hydrophila, Vibrio parahaemolyticus, etc.; 4. Infections of the abdominal cavity, bile duct, typhoid, etc.; 5. Bone and joint infections;

1 Bacterial bronchitis infection: Oral, 0.4g (4 tablets) once a day, or 0.3g (3 tablets) twice a day, 7-14 days. 2 Acute simple urinary tract infection: Oral, 0.4g (4 tablets) once a day, 7-10 days; complicated urinary tract infection: 0.4g (4 tablets) once a day, 14 days. 3 Simple gonorrhea: Oral, 0.3g (3 tablets) once a day, 2 times a day. 4 Prevention of surgical infection: Oral, 0.4g (4 tablets) once a day, 2-6 hours before surgery.

1. Gastrointestinal reactions are relatively common and may manifest as abdominal discomfort or pain, diarrhea, nausea or vomiting. 2. Central nervous system reactions: dizziness, headache, drowsiness or insomnia may occur. 3. Allergic reactions: rash, skin itching, occasionally exudative erythema multiforme and angioneurotic edema. Among them, photosensitivity reactions are more common than other commonly used quinolones. 4. A small number of patients may have increased serum aminotransferase and BUN values and decreased peripheral blood white blood cells, which are mostly mild and transient. 5. Occasionally occur: 1. Epileptic seizures, mental abnormalities, irritability, confusion, hallucinations, tremors. 2. Manifestations of interstitial nephritis such as hematuria, fever, and rash. 3. Crystalluria, more common when used in high doses. 4. Joint pain.

1. It is contraindicated for those who are allergic to this product or other quinolone drugs; 2. It is contraindicated for pregnant women, infants and patients under 18 years old; 3. Breastfeeding women should stop breastfeeding when using this product.

Precautions for children: It is forbidden to use in infants and patients under 18 years old. Precautions for pregnancy and lactation: It is forbidden to use in pregnant women. Precautions for the elderly: The renal function of elderly patients is reduced, and the dosage should be reduced as appropriate.

1. This product has little effect on the liver metabolism and body clearance of theophylline drugs and caffeine. 2. Aluminum sulfate and antacids can slow down the absorption rate of this product by 25%, and reduce the area under the curve (AUC) by about 30%. If saccharofaluminum sulfate and antacids are taken 4 hours before or 6 hours after taking this product, the effect will be minimal. 3. Combination with fenbufen can cause central nervous system excitement and epileptic seizures. 4. Probenecid can delay the excretion of this product, increase the average area under the curve (AUC) by 63%, extend the average peak time (tmax) by 50%, and increase the average peak concentration (Cmax) by 4%; therefore, when used together, toxicity may occur due to the increased blood concentration of this product. 5. It can enhance the effects of oral anticoagulants such as warfarin, and the prothrombin time and other items should be monitored. 6. Urine alkalinizers can reduce the solubility of this product in urine, leading to crystalluria and nephrotoxicity. 7. Didanosine (DDI) preparations contain aluminum and magnesium that can chelate with quinolones and should not be used together. 8. When used together with cyclosporine, the blood concentration of cyclosporine can be increased. The blood concentration of cyclosporine must be monitored and the dosage adjusted. 9. Nutritional supplements and vitamins containing metal ions should not be taken within 2 hours before or after taking this product.

Keep away from light and store in sealed container.

0.1g (calculated as lomefloxacin)

36 months

PKU HealthCare Corp., Ltd.

• Founded in:

  1993-05-18

• Address:

  No. 21, Fangzheng Avenue, Shuitu Town, Beibei District, Chongqing

• Tax NO.:

  91500000450533779H

• Registered Funds:

  595.987425 yuan

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