Supply High Purity 99% Cyclosporin Powder CAS 59865-13-3
GMP ISO 5 Inquiries
59865-13-3
0%
Foil Bag, Drum
2022-12-31
Minoxidil,Paracetamol,Diclofenac sodium,fenbendazole,Ivermectin
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Product Description
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Seller Information
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Inquiry History
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Description
Product descriptionProduct Name: Cyclosporin
Synonyms Name: Cyclosporine A
CAS No.: 59865-13-3
Molecular Formula: C62H111N11O12
Cyclosporin or cyclosporine A, is an immunosuppressant drug. Cyclosporine widely used in post-allogeneic organ transplant to reduce the activity of the patient's immune system, and therefore the risk of organ rejection. Cyclosporine has been studied in transplants of skin, heart, kidney, liver, lung, pancreas, bone marrow, and small intestine. Cyclosporine initially isolated from the fungus Tolypocladium inflatum isolated from a soil, ciclosporine is a cyclicnonribosomal peptide of 11 amino acids and contains a single D-amino acid, which are rarely encountered in nature.
Cyclosporine is thought to bind to the cytosolic protein cyclophilin(immunophilin) of immunocompetent lymphocytes, especially T-lymphocytes. This complex of ciclosporin and cyclophilin inhibits calcineurin, which, under normal circumstances, is responsible for activating the transcription of interleukin 2. In T-cells, activation of the T-cell receptor normally increases intracellular calcium, which acts via calmodulin to activate calcineurin. Calcineurin then dephosphorylates the transcription factor NF-AT (nuclear factor of activated T-cells), which moves to the nucleus of the T-cell and increases the activity of genes coding for IL-2 and related cytokines. Ciclosporin prevents the dephosphorlyation of NF-AT by binding to cyclophilin.[7] It also inhibits lymphokine production andinterleukin release and, therefore, leads to a reduced function of effector T-cells. It does not affect cytostaticactivity.
It also has an effect on mitochondria. Ciclosporine prevents the mitochondrial permeability transition pore from opening, thus inhibiting cytochrome c release, a potent apoptotic stimulation factor. However, this is not the primary mechanism of action for clinical use, but rather an important effect for research on apoptosis.
Functions1) It is an immunosuppressant drug.
2) Cyclosporin A is widely used in post-allogeneic organ transplant to reduce the activity of the patient's immune system, and therefore the risk of organ rejection.
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Xi'an Tian guangyuan Biotech Co.,Ltd.
Tel: 86-29-86333380
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Company information
XIAN Tian Guangyuan Biotech Co.,Ltd.was founded in May 2003, is a professional animal and plant extracts modern and advanced enterprise object, chemical intermediates and active ingredients of natural active throughout the country, plant extracts industry, research and development, production, marketing and other areas have a strong strength. The company is headquartered in the outskirts of Xi'an, under research and development center as well as analysis and testing center, comprehensive strength in the national forefront of the industry. Companies rely on the wisdom and innovation of advanced technology, scientific management and all the staff and a good team spirit, will enable the company to develop a domestic industry with sik-class product quality and international competitiveness of enterprises.
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We deliver goods within 3 days for small order, 7-10 days for bulk order.
CertificatesBasic Info-
Product Name:
Cyclosporin A
Other Name:ol27-400;s7481f1;sandimmun;sandimmune;ANTIBIOTIC S 7481F1;ANTIBIOTIC S 7481FI;CICLOSPORIN;CICLOSPORIN A
CAS No.:59865-13-3
Molecular Formula:C62H111N11O12
InChIKeys:PMATZTZNYRCHOR-UHFFFAOYSA-N
Molecular Weight:1202.61
Exact Mass:1201.841309
EC Number:200-835-2
DSSTox ID:DTXSID0020365
Color/Form:Forms white prismatic crystals from acetone
HScode:2941909000
Categories:
Characteristics-
PSA:
279 Ų
XLogP3:2.92 (LogP)
Appearance:white solid
Density:1.0±0.1 g/cm3
Melting Point:148-151°C
Boiling Point:1293.8°C at 760 mmHg
Flash Point:87℃
Refractive Index:1.468
Water Solubility:soluble in dimethyl sulfoxide and ethanol. Insoluble in water.ethanol: 30 mg/mL
Storage Conditions:2-8°C
Toxicity:LD50 in mice, rats, rabbits (mg/kg): 107, 25, >10 i.v.; 2329, 1480, >1000 orally (Ryffel)
Specific rotation:D20 -244° (c = 0.6 in chloroform); D20 -189° (c = 0.5 in methanol)
Air and Water Reactions:Slightly water soluble (NTP, 1992).
Reactive Group:Amides and Imides
Reactivity Profile:CYCLOSPORIN A is an amide. Amides/imides react with azo and diazo compounds to generate toxic gases. Flammable gases are formed by the reaction of organic amides/imides with strong reducing agents. Amides are very weak bases (weaker than water). Imides are less basic yet and in fact react with strong bases to form salts. That is, they can react as acids. Mixing amides with dehydrating agents such as P2O5 or SOCl2 generates the corresponding nitrile. The combustion of these compounds generates mixed oxides of nitrogen (NOx).
Hazard IdentificationClassification of the substance or mixture
Acute toxicity - Category 4, Oral
Carcinogenicity, Category 1B
Reproductive toxicity, Category 1B
GHS label elements, including precautionary statements
Pictogram(s) 
Signal word Danger
Hazard statement(s) H302 Harmful if swallowed
H350 May cause cancer
H360 May damage fertility or the unborn child
Precautionary statement(s) Prevention P264 Wash ... thoroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P203 Obtain, read and follow all safety instructions before use.
P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/...
Response P301+P317 IF SWALLOWED: Get medical help.
P330 Rinse mouth.
P318 IF exposed or concerned, get medical advice.
Storage P405 Store locked up.
Disposal P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.
Other hazards which do not result in classification
no data available
Handling and StoragePrecautions for safe handling
Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.
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Seller Information
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Business Type:
Manufactory
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Main Products:
Minoxidil,Paracetamol,Diclofenac sodium,fenbendazole,Ivermectin
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Location:
I-City unit 3, South of Tangyan Road, Hi-Tech Industrial Zone, Xi'an City, Shaanxi Province, China
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Payment Terms:
TT against copy of documents,TT against B/L draft before shipment,100% TT in advance
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Average lead Time:
7
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Total Annual Revenue:
$1 million-$2.5 million
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Total Employees:
51-100
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Year of Establishment:
2015
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Certifications:
HACCP,Halal,GMP,ISO
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Inquiry History5 Inquiries
Country Product Purchase Quantity Date Posted 
United States
Cyclosporine A
100 G Aug 21, 2025 
Pakistan
CICLOSPORIN
1 KG Sep 30, 2024
Pakistan
CYCLOSPORINE
1 KG Dec 26, 2025
Pakistan
Cyclosporine
8 KG Sep 5, 2024 
India
Cyclosporine
1.00 KG Dec 22, 2023 Post an enquiry for this product
