Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase
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Product Description
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Seller Information
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Description
ProductName NSC319726 Cat No CEI-0917 Description NSC319726 is a p53(R175) mutant reactivator, exhibits growth inhibition in cells expressing mutant p53, with IC50 of 8 nM for p53(R175) mutant, shows no inhibition for p53 wild-type cells. CAS No 71555-25-4 Molecular Weight 234.32 Storage 2 years -20 centigrade Powder; 2 weeks 4 centigrade in DMSO; 6 months -80 centigrade in DMSO. Targets p53(R175) IC50 8 nM Molecular Formula C11H14N4S Chemical Name 1-Azetidinecarbothioic acid, 2-[1-(2-pyridinyl)ethylidene]hydrazide Solubility DMSO mg/mL; Water mg/mL; Ethanol mg/mL In vitro NSC319726 is a p53(R175) mutant reactivator, exhibits growth inhibition in cells expressing mutant p53, with IC50 of 8 nM for p53(R175) mutant, shows no inhibition for p53 wild-type cells, shows 10- to 100-fold selectivity over the other hotspot p53 mutants. NSC319276 induces p53(R175)-mutant-dependent apoptosis. NSC319726 treatment induces a WT-like conformational change in the p53(R175) mutant protein that restores sequence-specific p53 transcription. The activity of NSC319726 depends on the zinc ion chelating properties of the compound as well as redox changes. In vivo NSC319726 (5mg/kg, 7days) exhibits greater toxicity for p53(R172H/R172H) mice, with only 30% survival, as compared to 100% survival for p53+/+ and p53-/- mice. NSC319726 inhibits the growth of TOV112D-p53(R175H) xenografts, but not H460 (p53+/+) and MDAMB468-p53(R273W) xenografts. category Inhibitors(c1514) cas_num 71555-25-4 Basic Info-
Product Name:
1-Azetidinecarbothioic acid 2-[1-(2-pyridinyl)ethylidene]hydrazide
Other Name:1-Azetidinecarbothioic acid,2-[1-(2-pyridinyl)ethylidene]hydrazide;1-Azetidinecarbothioic acid,[1-(2-pyridinyl)ethylidene]hydrazide;1-Azetidinecarbothioic acid 2-[1-(2-pyridinyl)ethylidene]hydrazide;NSC 319726;ZMC 1
CAS No.:71555-25-4
Molecular Formula:C11H14N4S
InChIKeys:InChIKey=XDHBUMNIQRLHGO-UHFFFAOYSA-N
Molecular Weight:234.33
Exact Mass:234.32
Categories:
Characteristics-
Density:
1.3±0.1 g/cm3
Melting Point:175-176 °C @ Solvent: Acetonitrile
Boiling Point:367.7°C at 760 mmHg
Flash Point:176.2±25.7 °C
Refractive Index:1.659
Hazard IdentificationClassification of the substance or mixture
no data available
GHS label elements, including precautionary statements
Pictogram(s) no data available Signal word no data available
Hazard statement(s) no data available
Precautionary statement(s) Prevention no data available
Response no data available
Storage no data available
Disposal no data available
Other hazards which do not result in classification
no data available
Handling and StoragePrecautions for safe handling
Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.
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Seller Information
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Business Type:
Manufactory
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Main Products:
Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase
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Location:
Shirley, New York 11967, USA
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Payment Terms:
TT against copy of documents,D/P
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Average lead Time:
15
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Total Annual Revenue:
$1 million-$2.5 million
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Year of Establishment:
2004
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Country Product Purchase Quantity Date Posted Post an enquiry for this product