Voreloxin Hydrochloride
175519-16-1
0.98%
2026-07-12
Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase
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Product Description
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Seller Information
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Description
ProductName Voreloxin Hydrochloride Cat No CEI-1573 Product Overview Voreloxin is a small molecule and a naphthyridine analogue with antineoplastic activity. Vosaroxin intercalates into DNA in a site-specific manner and blocks the re-ligation process carried out by topoisomerase II during DNA replication. As a result, inhibition of DNA replication, RNA and protein synthesis occurs, followed by cell cycle arrest at G2 phase and induced p53-independent apoptosis. This agent shows a favorable toxicity profile in several aspects: it does not generate reactive oxygen species, as do anthracyclines, reducing the risk of cardiotoxicity; it is not a P-glycoprotein (P-gp) substrate, and thereby evades the common mechanism for multidrug resistance; and it has limited distribution to normal tissues and a more chemically stable molecular structure. CAS No 175519-16-1 Molecular Weight 437.9 Purity 0.98 Storage Store at -20°C Synonyms SNS-595 Hydrochloride; Vosaroxin Hydrochloride; AG 7352 Hydrochloride Targets Antineoplastic naphthyridine analogue Molecular Formula C18H20ClN5O4S Chemical Name 7-[(3S,4S)-3-methoxy-4-(methylamino)pyrrolidin-1-yl]-4-oxo-1-(1,3-thiazol-2-yl)-1,8-naphthyridine-3-carboxylic acid; hydrochloride Solubility Soluble in DMSO Shipping Conditions Evaluation sample solution: ship with blue ice. All other available size: ship with RT, or blue ice upon request category Specialty Chemicals(c26) cas_num 175519-16-1 Basic Info-
Product Name:
AG 7352 Hydrochloride
Other Name:AG 7352 Hydrochloride;SNS-595 Hydrochloride;Voreloxin (Hydrochloride);Vosaroxin Hydrochloride;(3S-trans)-1,4-Dihydro-7-[3-methoxy-4-(methylamino)-1-pyrrolidinyl]-4-oxo-1-(2-thiazolyl)-1,8-naphthyridine-3-carboxylic acid monohydrochloride;Voreloxin (SNS-595) HCl
CAS No.:175519-16-1
Molecular Formula:C18H20ClN5O4S
InChIKeys:JJZCCQHWCOXGCL-QNTKWALQSA-N
Molecular Weight:437.9005
Exact Mass:437.092
DSSTox ID:DTXSID70438412
Categories:
Characteristics-
PSA:
136
XLogP3:2.22130
Hazard IdentificationClassification of the substance or mixture
no data available
GHS label elements, including precautionary statements
Pictogram(s) no data available Signal word no data available
Hazard statement(s) no data available
Precautionary statement(s) Prevention no data available
Response no data available
Storage no data available
Disposal no data available
Other hazards which do not result in classification
no data available
Handling and StoragePrecautions for safe handling
Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.
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Seller Information
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Business Type:
Manufactory
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Main Products:
Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase
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Location:
Shirley, New York 11967, USA
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Payment Terms:
TT against copy of documents,D/P
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Average lead Time:
15
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Total Annual Revenue:
$1 million-$2.5 million
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Year of Establishment:
2004
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Country Product Purchase Quantity Date Posted Post an enquiry for this product