adenosylcobinamide-phosphate guanylyltransferase
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CAS No.:
169592-55-6
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2026-07-03
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United States
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Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase
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ProductName adenosylcobinamide-phosphate guanylyltransferase Cat No EXWM-3274 Description In Salmonella typhimurium LT2, under anaerobic conditions, CobU (EC 2.7.7.62 and EC 2.7.1.156), CobT (EC 2.4.2.21), CobC (EC 3.1.3.73) and CobS (EC 2.7.8.26) catalyse reactions in the nucleotide loop assembly pathway, which convert adenosylcobinamide (AdoCbi) into adenosylcobalamin (AdoCbl). CobT and CobC are involved in 5,6-dimethylbenzimidazole activation whereby 5,6-dimethylbenzimidazole is converted to its riboside, α-ribazole. The second branch of the nuclotide loop assembly pathway is the cobinamide (Cbi) activation branch where AdoCbi or adenosylcobinamide-phosphate is converted to the activated intermediate AdoCbi-GDP by the bifunctional enzyme Cob U. The final step in adenosylcobalamin biosynthesis is the condensation of AdoCbi-GDP with α-ribazole, which is catalysed by EC 2.7.8.26, cobalamin synthase (CobS), to yield adenosylcobalamin. CobU is a bifunctional enzyme that has both kinase (EC 2.7.1.156) and guanylyltransferase (EC 2.7.7.62) activities. However, both activities are not required at all times.The kinase activity has been proposed to function only when S. typhimurium is assimilating cobinamide whereas the guanylyltransferase activity is required for both assimilation of exogenous cobinamide and for de novo synthesis of adenosylcobalamin. The guanylyltransferase reaction is a two-stage reaction with formation of a CobU-GMP intermediate. Guanylylation takes place at histidine-46. Form Liquid or lyophilized powder Enzyme Commission Number EC 2.7.7.62 CAS No 169592-55-6 Storage Store it at +4 ºC for short term. For long term storage, store it at -20 ºC～-80 ºC. Synonyms CobU; adenosylcobinamide kinase/adenosylcobinamide-phosphate guanylyltransferase; AdoCbi kinase/AdoCbi-phosphate guanylyltransferase Reaction GTP + adenosylcobinamide phosphate = diphosphate + adenosylcobinamide-GDP Notes This item requires custom production and lead time is between 5-9 weeks. We can custom produce according to your specifications. cas_num 169592-55-6 category Specialty Chemicals(c26) Basic Info-
Product Name:
adenosylcobinamide-phosphate guanylyltransferase
CAS No.:169592-55-6
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Seller Information
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Business Type:
Manufactory
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Main Products:
Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase
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Location:
Shirley, New York 11967, USA
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Payment Terms:
TT against copy of documents,D/P
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Average lead Time:
15
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Total Annual Revenue:
$1 million-$2.5 million
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Year of Establishment:
2004
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