| Identified uses | Industrial and scientific research use. |
| Uses advised against | no data available |
SECTION 2: Hazard identification
2.1Classification of the substance or mixture
2.2GHS label elements, including precautionary statements
| Pictogram(s) | No symbol. |
| Signal word | No signal word |
| Hazard statement(s) | none |
| Precautionary statement(s) |
| Prevention | none |
| Response | none |
| Storage | none |
| Disposal | none |
2.3Other hazards which do not result in classification
SECTION 3: Composition/information on ingredients
3.1Substances
| Chemical name | Common names and synonyms | CAS number | EC number | Concentration |
| Aspartic acid | Aspartic acid | 56-84-8 | 200-291-6 | 100% |
SECTION 4: First-aid measures
4.1Description of necessary first-aid measures
If inhaled
Fresh air, rest. Refer for medical attention.
Following skin contact
Remove contaminated clothes. Rinse and then wash skin with water and soap.
Following eye contact
First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.
Following ingestion
Rinse mouth. Do NOT induce vomiting. Give one or two glasses of water to drink.
4.2Most important symptoms/effects, acute and delayed
4.3Indication of immediate medical attention and special treatment needed, if necessary
Basic treatment: Establish a patent airway (oropharyngeal or nasopharyngeal airway, if needed). Suction if necessary. Watch for signs of respiratory insufficiency and assist ventilations if needed. Administer oxygen by nonrebreather mask at 10 to 15 L/min. Monitor for pulmonary edema and treat if necessary . Monitor for shock and treat if necessary . Anticipate seizures and treat if necessary . For eye contamination, flush eyes immediately with water. Irrigate each eye continuously with 0.9% saline (NS) during transport . Do not use emetics. For ingestion, rinse mouth and administer 5 ml/kg up to 200 ml of water for dilution if the patient can swallow, has a strong gag reflex, and does not drool . Cover skin burns with dry sterile dressings after decontamination . Poisons A and B
SECTION 5: Fire-fighting measures
5.1Suitable extinguishing media
In case of fire in the surroundings, use appropriate extinguishing media.
5.2Specific hazards arising from the chemical
Combustible. Finely dispersed particles form explosive mixtures in air.
5.3Special protective actions for fire-fighters
In case of fire in the surroundings, use appropriate extinguishing media.
SECTION 6: Accidental release measures
6.1Personal precautions, protective equipment and emergency procedures
Sweep spilled substance into covered containers. If appropriate, moisten first to prevent dusting. Wash away remainder with plenty of water. Personal protection: particulate filter respirator adapted to the airborne concentration of the substance.
6.2Environmental precautions
Sweep spilled substance into covered containers. If appropriate, moisten first to prevent dusting. Wash away remainder with plenty of water. Personal protection: particulate filter respirator adapted to the airborne concentration of the substance.
6.3Methods and materials for containment and cleaning up
Collect and arrange disposal. Keep the chemical in suitable and closed containers for disposal. Remove all sources of ignition. Use spark-proof tools and explosion-proof equipment. Adhered or collected material should be promptly disposed of, in accordance with appropriate laws and regulations.
SECTION 7: Handling and storage
7.1Precautions for safe handling
NO open flames. Prevent build-up of electrostatic charges (e.g., by grounding). Closed system, dust explosion-proof electrical equipment and lighting. Prevent deposition of dust. Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
7.2Conditions for safe storage, including any incompatibilities
Separated from strong oxidants.
SECTION 8: Exposure controls/personal protection
8.1Control parameters
Occupational Exposure limit values
| Component | Aspartic acid |
| CAS No. | 56-84-8 |
| Limit value - Eight hours | Limit value - Short term |
| ppm | mg/m3 | ppm | mg/m3 |
| Latvia |
| 10 |
|
|
| Remarks |
Biological limit values
8.2Appropriate engineering controls
Ensure adequate ventilation. Handle in accordance with good industrial hygiene and safety practice. Set up emergency exits and the risk-elimination area.
8.3Individual protection measures, such as personal protective equipment (PPE)
Eye/face protection
Skin protection
Respiratory protection
Use local exhaust or breathing protection.
Thermal hazards
SECTION 9: Physical and chemical properties and safety characteristics
| Physical state | Solid. |
| Colour | White. |
| Odour | no data available |
| Melting point/freezing point | 230 °C. |
| Boiling point or initial boiling point and boiling range | > 324 °C. |
| Flammability | Combustible. |
| Lower and upper explosion limit/flammability limit | no data available |
| Flash point | 107°C(lit.) |
| Auto-ignition temperature | > 400 °C. |
| Decomposition temperature | 324°C |
| pH | 3.03. Remarks:Suspension at ambient temperature. |
| Kinematic viscosity | no data available |
| Solubility | In water: 2.09 g/kg. Temperature:0 °C. Remarks:Selected results from the solubility-temperature equation.;3.53 g/kg. Temperature:15 °C. Remarks:Selected results from the solubility-temperature equation.;4.2 g/kg. Temperature:20 °C. Remarks:Selected results from the solubility-temperature equation. |
| Partition coefficient n-octanol/water | log Pow = -3.89. Remarks:No further data are available. |
| Vapour pressure | 0 Pa. Temperature:25 °C. Remarks:The result was obtained by the Modified Grain method. |
| Density and/or relative density | 1.66. Temperature:13 °C.;1.661. Temperature:13 °C. |
| Relative vapour density | no data available |
| Particle characteristics | no data available |
SECTION 10: Stability and reactivity
10.1Reactivity
Decomposes on burning. This produces toxic gases including nitrogen oxides. Reacts violently with oxidants.
10.2Chemical stability
10.3Possibility of hazardous reactions
Dust explosion possible if in powder or granular form, mixed with air. If dry, it can be charged electrostatically by swirling, pneumatic transport, pouring, etc.
10.4Conditions to avoid
10.5Incompatible materials
10.6Hazardous decomposition products
SECTION 11: Toxicological information
Acute toxicity
- Oral: LD50 - rat (male/female) - 2 000 mg/kg bw.
- Inhalation: no data available
- Dermal: LD50 - rabbit - 5 000 mg/kg bw.
Skin corrosion/irritation
Serious eye damage/irritation
Respiratory or skin sensitization
Germ cell mutagenicity
Carcinogenicity
Reproductive toxicity
STOT-single exposure
The substance is irritating to the eyes and respiratory tract.
STOT-repeated exposure
Aspiration hazard
Evaporation at 20°C is negligible; a nuisance-causing concentration of airborne particles can, however, be reached quickly when dispersed, especially if powdered.
SECTION 12: Ecological information
12.1Toxicity
- Toxicity to fish: LC50 - Danio rerio (previous name: Brachydanio rerio) - > 100 mg/L - 96 h.
- Toxicity to daphnia and other aquatic invertebrates: EC50 - Daphnia magna - > 100 mg/L - 48 h.
- Toxicity to algae: EC50 - Pseudokirchneriella subcapitata (previous names: Raphidocelis subcapitata, Selenastrum capricornutum) - > 100 mg/L - 72 h.
- Toxicity to microorganisms: EC50 - activated sludge of a predominantly domestic sewage - > 300 mg/L - 3 h. Remarks:Respiration rate.
12.2Persistence and degradability
AEROBIC: The biodegradation of L-aspartic acid was measured in several BOD5 tests. After 5 days, 48.5%(1) 38.7(2) and 80.5%(3) of the theoretical BOD was reached using a sewage inoculum. L-Aspartic acid was degraded by 81% BODT after 30 days using a sewage inoculum(4). In a second Warburg test using an activated sludge inoculum, 8.9, 16.2, and 28.8% BODT was reached after 0.25, 0.5, and 1 day, respectively(5). DL-Aspartic acid was rapidly degraded by 98 to >99% in a laboratory-scale activated sludge unit at initial concentrations of 599, 1198, 2396, and 4792 mg/L and average detention times of 20.5, 29, 42, and 85 hours, respectively(6). Samples of marine water from the Scheldt estuary, the Belgian coastal zone of the North Sea, and the English Channel were incubated with 14C-labeled DL-aspartic acid and relative rates of total utilization (incorporation plus respiration) of 2.7, 1.5, and 0.10%/hr, respectively, were measured over a 4-hour period(7). Based on these data, L-aspartic acid is expected to biodegrade rapidly.
12.3Bioaccumulative potential
An estimated BCF of 0.7 was calculated in fish for L-aspartic acid(SRC), using a water solubility of 5,360 mg/L(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is low(SRC).
12.4Mobility in soil
The Koc of L-aspartic acid is estimated as 39(SRC), using a water solubility of 5,360 mg/L(1) and a regression-derived equation(2). According to a classification scheme(3), this estimated Koc value suggests that L-aspartic acid is expected to have very high mobility in soil. However, L-aspartic acid has pKa values of 1.92, 3.87, and 9.87(5), indicating that this compound will exist as a zwitterion in the environment. In H(Al) montmorillonite, aspartic acid showed an L-2 type adsorption isotherm with an initial preferential sorption when compared with the solvent or other solutes followed by a decrease in sorption as more solute was sorbed(4).
12.5Other adverse effects
SECTION 13: Disposal considerations
13.1Disposal methods
Product
The material can be disposed of by removal to a licensed chemical destruction plant or by controlled incineration with flue gas scrubbing. Do not contaminate water, foodstuffs, feed or seed by storage or disposal. Do not discharge to sewer systems.
Contaminated packaging
Containers can be triply rinsed (or equivalent) and offered for recycling or reconditioning. Alternatively, the packaging can be punctured to make it unusable for other purposes and then be disposed of in a sanitary landfill. Controlled incineration with flue gas scrubbing is possible for combustible packaging materials.
SECTION 14: Transport information
14.1UN Number
| ADR/RID: Not dangerous goods. (For reference only, please check.) | IMDG: Not dangerous goods. (For reference only, please check.) | IATA: Not dangerous goods. (For reference only, please check.) |
14.2UN Proper Shipping Name
| ADR/RID: Not dangerous goods. (For reference only, please check.) | IMDG: Not dangerous goods. (For reference only, please check.) | IATA: Not dangerous goods. (For reference only, please check.) |
14.3Transport hazard class(es)
| ADR/RID: Not dangerous goods. (For reference only, please check.) | IMDG: Not dangerous goods. (For reference only, please check.) | IATA: Not dangerous goods. (For reference only, please check.) |
14.4Packing group, if applicable
| ADR/RID: Not dangerous goods. (For reference only, please check.) | IMDG: Not dangerous goods. (For reference only, please check.) | IATA: Not dangerous goods. (For reference only, please check.) |
14.5Environmental hazards
| ADR/RID: No | IMDG: No | IATA: No |
14.6Special precautions for user
14.7Transport in bulk according to IMO instruments
SECTION 15: Regulatory information
15.1Safety, health and environmental regulations specific for the product in question
| Chemical name | Common names and synonyms | CAS number | EC number |
| Aspartic acid | Aspartic acid | 56-84-8 | 200-291-6 |
| European Inventory of Existing Commercial Chemical Substances (EINECS) | Listed. |
| EC Inventory | Listed. |
| United States Toxic Substances Control Act (TSCA) Inventory | Listed. |
| China Catalog of Hazardous chemicals 2015 | Not Listed. |
| New Zealand Inventory of Chemicals (NZIoC) | Listed. |
| Philippines Inventory of Chemicals and Chemical Substances (PICCS) | Listed. |
| Vietnam National Chemical Inventory | Listed. |
| Chinese Chemical Inventory of Existing Chemical Substances (China IECSC) | Listed. |
| Korea Existing Chemicals List (KECL) | Listed. |
SECTION 16: Other information
Information on revision
| Creation Date | July 15, 2019 |
| Revision Date | July 15, 2019 |
Abbreviations and acronyms
- CAS: Chemical Abstracts Service
- ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
- RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
- IMDG: International Maritime Dangerous Goods
- IATA: International Air Transportation Association
- TWA: Time Weighted Average
- STEL: Short term exposure limit
- LC50: Lethal Concentration 50%
- LD50: Lethal Dose 50%
- EC50: Effective Concentration 50%
United States
Greece
Russia
