Lurasidon intermediates, intermediates of 367514-87-2/367514-88-3.
lurasidon base is an atypical antipsychotic, and the exact mechanism for treating schizophrenia remains as unclear as other atypical antipsychotics and may be related to the antagonism of dopamine D2 and 5 serotonin 2A (5-HT 2 A) receptors. It is used for the treatment of schizophrenia, and some studies have reported that lur asidone can improve cognitive function. The hcl salt lurasidon is API also large stock.
Product introduce：Lur-asidone is suitable for the treatment of schizophrenia. Lurasdone is an antagonist of dopamine D2 and 5-HT7, with IC50 values of 1.68 and 0.495 nM, respectively and is also a partial agonist of 5-HT1A receptor with IC50 value of 6.75 nM.
Functio n ：Lurasidon is used to treat mental illness. Many clinical trials show that it can improve psychotic symptoms, emotional symptoms and cognitive symptoms of schizophrenia patients, and has the safety advantages of little influence on glucose and lipid metabolism indexes and prolactin.
Origin：Lurasidon is an atypical antipsychotic drug developed by Dainippon Sumitomo Pharmaceutical Company of Japan. On October 28th, 2010, the US Food and Drug Administration (FDA) approved its marketing under the trade name for the treatment of schizophrenia.
| Name | 3-Piperazinyl-1,2-benzisothiazole hydrochloride |
| MF | C11H14ClN3S |
| MW | 255.76 |
| CAS | 87691-88-1 |
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Founded in 2012, Jinan Million Pharmaceutical Co., Ltd (Jinan Milin Pharmaceutical Co., Ltd) is a modern pharmaceutical enterprise guided by innovation. Million pharm has excellent research and development capabilities and complete industrial bases with international quality management system. It is dedicated to the research, development, production and customization of pharmaceuticals and advanced pharmaceutical intermediates.
Jinan Million Pharmaceutical Co., Ltd has been focusing on the research of Cerebro-cardiovascular drugs, Central nervous system drugs, Anti-cancer drugs, Antibacterial drugs and others for 12 years; the products are: Apixab a n, Lurasidon e , Bexagliflozin, Vortioxetine, L OXO -292/Selpercatinib, Baricitinib and intermediates. Million has worked with reputable customers, like METROCHEM API PVT LTD; BDR LIFESCIENCES PVT.LTD; SRINI CHEM; EVA PHARMA; PHARMAFFILIATES ANALYTICS & SYNTHETICS (P) LTD; ....from India, Egypt, Canada...
Jinan Million Pharmaceutical Co., Ltd has a 1,500㎡ R&D center in the Zhongguancun E Valley (Qihe) Incubator, equipped with complete test equipment, such as high-performance liquid chromatography, nuclear magnetic resonance spectrometer, liquid chromatography mass spectrometer, automatic polarimeter, etc., which can meet the needs of various laboratory scale tests in different conditions. The pilot workshop is equipped with 50L and 100L glass reactors, high and low temperature equipment, etc., which can support organic chemical reactions at -100°C or 200°C. In addition, Million has a production site in Linyi city with many independent production lines, such as: production line of Apixabn intermediate 20 tons/year, production line of Lurasidon intermediate 10 tons/year, which can meet the commercial production of various products.
The technical team is composed of high-level talents in major of pharmacy, bio-pharmaceutical or chemical synthesis, of which 10% has doctor’s degree and 15% has master’s degree. The team members are young and energetic with innovative spirit and willing to overcome obstacles.
Jinan Million Pharmaceutical Co., Ltd adheres to the business philosophy of "dedication and innovation", insists on pioneering and innovating, constantly improves the quality system, and vigorously trains technical and management talents to build an elite team and serves customers better. Looking forward to cooperate with you for joint development and common progress.
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