High Quality Lincomycin CAS 154-21-2 Powder Fast Shipping Good Price

Lincomycin More Info

Mechanism of Action

Lincomycin inhibits bacterial protein synthesis by binding to the 23S ribosomal subunit, specifically within the peptidyl transferase loop region of the 23S rRNA. This action blocks the elongation of bacterial proteins, thereby exerting a bacteriostatic effect.

Medical Uses

Lincomycin is used to treat infections caused by Gram-positive bacteria, including:

Staphylococci (e.g., Staphylococcus aureus)

Streptococci (e.g., β-hemolytic streptococci)

Pneumococci (Streptococcus pneumoniae)

Clostridia.

It is particularly effective for:

Respiratory infections

Abdominal infections

Skin and soft tissue infections

Bone and joint infections (e.g., osteomyelitis).

Lincomycin is also used as an alternative for patients allergic to penicillin.

Pharmacokinetics

Administration: Available in oral, injectable, and intramuscular forms.

Absorption: Moderate oral absorption, with plasma protein binding around 75%.

Distribution: Widely distributed in tissues, including bone.

Excretion: Primarily excreted in urine and bile.

Storage Conditions

Lincomycin should be stored in a sealed container at 2-8°C.

Safety and Precautions

Side Effects: Common side effects include diarrhea, nausea, vomiting, and skin rash. Severe side effects may include pseudomembranous colitis, jaundice, and low blood cell counts.

Allergic Reactions: Immediate medical attention is required for signs of allergic reactions, such as hives, difficulty breathing, or swelling of the face or throat.

Antibiotic-Associated Diarrhea: Lincomycin can cause overgrowth of normally harmless bacteria in the intestines, leading to severe diarrhea. This condition can occur even months after treatment and requires prompt medical attention.

Conclusion

Lincomycin is a broad-spectrum antibiotic with significant activity against Gram-positive bacteria. While its use has decreased due to the availability of more potent derivatives like clindamycin, it remains an important option for treating severe infections, especially in penicillin-allergic patients.

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For non-ready stock, please contact HyperChem sales team to negotiate.

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