API 2-Aminopyrimidine

Name

2-Aminopyrimidine

CAS number

109-12-6

Description

Physical Properties

Melting Point: It has a melting point of around 127 - 129 °C. This property allows it to change from a solid to a liquid state under specific temperature conditions.

Solubility: It is sparingly soluble in water but soluble in organic solvents like ethanol, methanol, and chloroform. This solubility characteristic affects its application and separation in different chemical processes.

Chemical Properties

Basicity: The amino group in 2 - Aminopyrimidine gives it basic properties. It can react with acids to form salts, which is an important chemical reaction characteristic.

Reactivity: It can participate in various chemical reactions. The amino group can undergo reactions such as acetylation and alkylation. The pyrimidine ring, being an aromatic heterocycle, can also undergo electrophilic substitution reactions.

Synthesis

It can be synthesized through different methods. One common way is the reaction of guanidine with ethyl orthoformate or formamide. In this process, the pyrimidine ring is formed first, and then the amino group is introduced. Another method involves the condensation of 1, 3 - dicarbonyl compounds with urea or thiourea in the presence of a base.

Applications

Pharmaceutical Field: It serves as a crucial intermediate in the synthesis of numerous pharmaceuticals, including antifungal drugs, antiviral drugs, and some antihypertensive drugs.

Agrochemical Industry: It is used in the production of certain pesticides and herbicides. The pyrimidine structure and the amino group can endow the compounds with good biological activities.

Materials Science: It can be utilized in the preparation of some functional materials, such as being used as a ligand in coordination polymers or as a building block in the synthesis of organic semiconductors.

Molecular Formula

C₄H₅N₃

Molecular Weight

95.1

Appearance

Solid powder

Quality Standard

USP, EP, BP, CP

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 – 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years).

Shelf Life

>2 years if stored properly

Sample package

Aluminium foil bag

Commercial package

Aluminium Tin, Fiber drum

Origin

China