Manufacturer supplement Urolithin A 98% purity Powder

I. Overview

Urolithin A is a naturally occurring polyphenolic metabolite with the chemical name 3,8-Dihydroxy-6H-dibenzo[b,d]pyran-6-one. Its molecular formula is C₁₃H₈O₄, with a molecular weight of 228.20. Urolithin A is produced through the microbial metabolism of ellagitannins or ellagic acid in the gut. Ellagitannins are abundant in foods such as pomegranates, strawberries, walnuts, and berries; however, Urolithin A itself is not directly present in these foods but is generated by specific gut microbiota.

Urolithin A exhibits significant anti-inflammatory, antioxidant, antiproliferative, and anti-aging properties. It can cross the blood-brain barrier and demonstrates potential therapeutic effects in various disease models. Its biological activities are primarily mediated through the following mechanisms:

1. Induction of Mitophagy: Promotes the clearance of damaged mitochondria by cells, enhancing mitochondrial function and thereby delaying aging.
2. Antioxidant Effects: Directly scavenges free radicals and activates the Nrf2 antioxidant pathway, strengthening cellular antioxidant defenses.
3. Anti-inflammatory Actions: Inhibits the release of inflammatory mediators (e.g., IL-1β, IL-6, and TNFα) and reduces the activation of inflammatory signaling pathways.
4. Inhibition of Tumor Cell Growth: Suppresses the proliferation and spread of tumor cells by inducing cell cycle arrest and apoptosis.

II. Applications

1. Anti-Aging and Muscle Health
   • Improvement of Mitochondrial Function: Urolithin A enhances mitochondrial function by promoting mitophagy, thereby delaying age-related muscle decline.
   • Enhancement of Muscle Strength and Endurance: Clinical trials have demonstrated that Urolithin A supplementation significantly improves muscle strength and exercise performance in middle-aged and elderly individuals.
   • Prevention of Sarcopenia: Sarcopenia, the age-related loss of muscle mass and strength, may potentially be mitigated by Urolithin A.
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2. Neuroprotection
   • Alzheimer's Disease: Urolithin A reduces amyloid-beta (Aβ) deposition, inhibits neuronal apoptosis, enhances neurogenesis, and improves cognitive function.
   • Parkinson's Disease: Protects dopaminergic neurons by suppressing neuroinflammation and oxidative stress, thereby slowing disease progression.
   • Other Neurodegenerative Diseases: The antioxidant and anti-inflammatory properties of Urolithin A confer potential therapeutic value in various neurodegenerative disorders.
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3. Cardiovascular Protection
   • Regulation of Lipid Metabolism: Lowers levels of low-density lipoprotein cholesterol (LDL-C) and total cholesterol while increasing the ratio of high-density lipoprotein cholesterol (HDL-C), preventing atherosclerosis.
   • Reduction of Blood Pressure and Blood Glucose: Maintains normal blood pressure and glucose levels by promoting vascular relaxation, improving endothelial function, and enhancing insulin sensitivity.
   • Treatment of Diabetic Cardiomyopathy: Induces autophagy to clear damaged mitochondria and protein aggregates, reducing myocardial fibrosis and improving cardiac function.
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4. Skin Health
   • Anti-Wrinkle and Anti-Aging Effects: Topical application of Urolithin A-containing skincare products significantly reduces wrinkles, increases collagen types I and III in the skin, and decreases skin inflammation.
   • Sun Protection and Anti-Photoaging: Protects the skin from UVB-mediated photodamage, reducing skin yellowing, dullness, and sagging.
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5. Antitumor Activity
   • Inhibition of Tumor Cell Proliferation: Urolithin A suppresses the growth of various tumor cells, including prostate and colon cancer, by inducing cell cycle arrest and apoptosis.
   • Adjuvant Antitumor Therapy: Serves as an adjuvant treatment to enhance the efficacy of antitumor drugs.
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6. Bone and Joint Health
   • Improvement of Osteoarthritis: Urolithin A significantly enhances mitochondrial respiration and autophagy in knee chondrocytes of osteoarthritis patients, reduces cartilage degeneration and synovial inflammation, and alleviates joint pain.
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7. Metabolic Disorders
   • Anti-Obesity Effects: Induces the activation of brown adipose tissue and the browning of white adipose tissue, promoting fat catabolism and preventing diet-induced fat accumulation.
   • Improvement of Insulin Sensitivity: Enhances insulin sensitivity, aiding in the treatment of type 2 diabetes.
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8. Immunomodulation
   • Enhancement of Immunity: Promotes the proliferation and differentiation of immune cells, enhances their activity, and boosts overall immune function.
   • Anti-Inflammatory and Anti-Infective Effects: Prevents and treats infectious diseases by inhibiting the release of inflammatory mediators.