Dapoxetine RC00265

Manufacturer: Hangzhou Royalchem Co.,LTD.

Website:   www.cnroyalchem.com

【 Providing a complete set of intermediates and impurities for Dapoxetine 】

【 Providing a complete set of intermediates and impurities for Dapoxetine 】

【 Providing a complete set of intermediates and impurities for Dapoxetine 】

Dapoxetine (INN), also known as Priligy, is a selective serotonin reuptake inhibitor (SSRI) used for the treatment of premature ejaculation (PE) in men. It is the first oral medication approved by the European Medicines Agency (EMA) for this condition.

Chemical Structure: Dapoxetine is a short-acting SSRI with a chemical structure similar to other SSRIs, such as fluoxetine and paroxetine. It is a racemic mixture of two enantiomers, R-dapoxetine and S-dapoxetine.

Mechanism of Action: Dapoxetine works by selectively inhibiting the reuptake of serotonin (5-HT) into the presynaptic neuron. This leads to an increase in the concentration of serotonin in the synaptic cleft, which can prolong the time to ejaculation by modulating the sympathetic nervous system activity involved in the ejaculatory reflex.

Pharmacokinetics: Dapoxetine is rapidly absorbed after oral administration, with peak plasma concentrations reached within 1-2 hours. It has a short elimination half-life of approximately 1.5-3 hours, which allows for a rapid onset of action and quick clearance from the body. Dapoxetine is metabolized primarily by the enzyme CYP2D6, and its main metabolites include desmethyldapoxetine and naphthoxylamine.

Clinical Use: Dapoxetine is indicated for the treatment of premature ejaculation (PE) in adult men. It is typically taken as a single dose (30 mg or 60 mg) one to three hours before anticipated sexual activity. Dapoxetine should not be used in combination with other SSRIs due to the risk of serotonin syndrome.

Adverse Effects: Common side effects associated with dapoxetine use may include nausea, dizziness, headache, fatigue, and dry mouth. Less common but potentially serious side effects include priapism (prolonged erection), seizure, and hyponatremia (low sodium levels in the blood). Patients with certain medical conditions, such as liver or kidney disease, should consult their healthcare provider before using dapoxetine.

Precautions and Warnings: Dapoxetine should not be used by individuals under the age of 18. It is contraindicated in patients taking monoamine oxidase inhibitors (MAOIs), tricyclic antidepressants (TCAs), or other SSRIs. Pregnant and breastfeeding women should not use dapoxetine. Patients with a history of alcohol abuse, liver or kidney disease, or bleeding disorders should discuss the risks and benefits of dapoxetine therapy with their healthcare provider.

In conclusion, dapoxetine is an SSRI medication specifically designed for the treatment of premature ejaculation in men. It works by inhibiting the reuptake of serotonin, leading to increased levels of serotonin in the synaptic cleft and prolonging the time to ejaculation. As with any medication, it is essential to weigh the potential benefits against the risks and consult with a healthcare professional before starting treatment with dapoxetine.