Chemical Profile and Molecular Characteristics
Acipimox (CAS 51037-30-0) is a synthetic nicotinic acid derivative developed as a lipid-modifying agent with improved tolerability profile. Chemically identified as 5-methylpyrazine-2-carboxylic acid 4-oxide, the compound features a unique pyrazine ring system that distinguishes it structurally from traditional niacin derivatives. This molecular design preserves the beneficial effects on lipid metabolism while minimizing the prostaglandin-mediated side effects commonly associated with nicotinic acid therapy. The compound exists as a white to off-white crystalline powder with defined melting characteristics and good stability under recommended storage conditions.
Mechanism of Action and Pharmacological Effects
Acipimox functions as an agonist of the nicotinic acid receptor GPR109A (HM74A) in adipose tissue, leading to inhibition of hormone-sensitive lipase and subsequent reduction in free fatty acid mobilization from peripheral fat stores. This primary action results in decreased hepatic synthesis of very-low-density lipoproteins and ultimately reduces circulating levels of triglycerides and low-density lipoprotein cholesterol. Unlike nicotinic acid, Acipimox demonstrates minimal activation of the prostaglandin D2 pathway, which accounts for its significantly improved flushing profile and enhanced patient tolerability.
Therapeutic Applications and Clinical Uses
The primary therapeutic application of Acipimox is in the management of dyslipidemias, particularly hypertriglyceridemia and mixed dyslipidemia. It is indicated as adjunctive therapy to diet and other lipid-lowering agents in patients who require additional triglyceride reduction or who cannot tolerate conventional niacin formulations. Clinical studies demonstrate its efficacy in reducing triglyceride levels by 25-35% and increasing high-density lipoprotein cholesterol by 10-15%, while maintaining a favorable side effect profile that supports long-term therapeutic adherence.
Formulation Versatility and Pharmaceutical Development
We supply Acipimox active pharmaceutical ingredient suitable for development of immediate-release oral formulations, primarily hard gelatin capsules. The compound demonstrates excellent compatibility with standard pharmaceutical excipients and maintains chemical stability through various manufacturing processes. Our technical data supports formulation development with comprehensive information on dissolution characteristics, powder flow properties, and compaction behavior to facilitate robust product development.
Quality Specifications and Analytical Controls
Our Acipimox API complies with international pharmacopeial standards, with stringent controls for identity, purity, and potency. Critical quality attributes include HPLC purity (not less than 99.0%), controlled limits for related substances, residual solvents, and heavy metals. We employ validated chromatographic methods for comprehensive impurity profiling and provide detailed characterization data including spectroscopic identification (IR, NMR, MS) and crystallinity assessment to ensure consistent quality across production batches.
Safety Profile and Adverse Effect Management
Acipimox is generally well-tolerated, with the most common adverse effects being mild and transient vasodilation reactions that typically diminish with continued therapy. Compared to traditional niacin, the incidence and severity of flushing are significantly reduced. Other occasional side effects include gastrointestinal discomfort and pruritus, which rarely necessitate treatment discontinuation. The compound carries precautions for patients with pre-existing peptic ulcer disease and requires monitoring of hepatic function and glucose metabolism during prolonged therapy.
Stability Profile and Storage Recommendations
Acipimox demonstrates excellent long-term stability when stored in well-closed containers protected from light and moisture at controlled room temperature. Accelerated stability studies confirm maintenance of chemical potency and physical characteristics under ICH-recommended conditions. The compound is stable in both bulk form and finished dosage forms, with comprehensive stability data available to support regulatory submissions and shelf-life determinations.
Regulatory Status and Global Approvals
Our Acipimox API is supported by comprehensive regulatory documentation, including Drug Master Files and Certificates of Analysis meeting international requirements. The compound has received marketing authorization in multiple countries, primarily in European markets, for the management of dyslipidemia. Our manufacturing facilities maintain current Good Manufacturing Practice compliance and are prepared for regulatory inspections to support customer approvals.
Market Position and Therapeutic Niche
Acipimox occupies a specialized position in the lipid-lowering market as a well-tolerated alternative to conventional niacin therapy. While not a first-line agent, it serves an important role in patients who require additional triglyceride reduction or cannot tolerate other lipid-modifying therapies. The market for Acipimox is characterized by steady demand in specific therapeutic niches, particularly in managing mixed dyslipidemias where its unique tolerability profile offers distinct advantages.
Manufacturing Capabilities and Supply Assurance
We employ efficient synthetic routes incorporating modern chemical transformations and purification technologies to ensure consistent quality and supply reliability. Our manufacturing processes are optimized for environmental sustainability and cost-effectiveness, with multiple production sites providing supply chain security. We offer flexible batch sizes from kilogram quantities to commercial volumes, supported by comprehensive quality agreements and reliable logistics networks to meet global customer requirements.
Q1. Can I get a free sample?
We can send you a samll free sample, and you only need to pay for the shipping cost.
Q2. What is the HyperChem payment term?
T/T in advance
LC at sight
DP at sight
Bank transfer
PayPal
Bitcoin...
Q3. What is HyperChem shipment policy?
Our policy is to strive for the quickest shipment time possible.
For ready stock samples, they are usually shipped within 3 working days after payment received.
For non-ready stock, please contact HyperChem sales team to negotiate.
Q4. What is HyperChem shipment term?
By Express
FedEx UPS DHL EMS
Fast: 3-7 days around, high cost, door to door service
By Air
Suitable for more than 50kg
Fast: 3-7 days, hight cost, port to port, professional broker needed
By Sea
Suitable for more than 500kg
Fast: 7-45 days, low cost, port to port, professional broker needed
We will always attempt to utilize the quickest and most affordable way for customers to receive orders. And follow -up with customers via email for all shipment details as well as updated track information until it arrives without damage.
Q5. What HyperChem will provide after shipment?
For sample orders:
After shipment is done, an timely email including:
1. Track details (Fedex /TNT/DHL/EMS Track number)
2. Packaging photo
3. COA, MSDS, etc
4. Dispatch date & Estimated arriving time
5. Shipping invoice
For commercial orders
A full set of shipment documents as well as package photos can be provided in scan-copy and original, to help customers complete the customs clearance process.
Established in 2013, Hyper Chem has exclusive tie-ups with leading manufacturers, supplying raw materials produced in GMP and ISO 9002 certified facilities, and provides high-quality ingredients and raw materials to cater to the requirements of our diverse range of clients.
Among them, our key client industrial sectors around the global are:
Pharmaceuticals
Nutrition Ingredients/ Dietary supplements
Cosmetic Ingredients
Food Ingredients
Veterinary API
Agriculture fertilizer
Custom Synthesis lab supply
HyperChem provides to its wonderful and honorable clients comprehensive purchasing and distribution services which ensure that we are delivering the right generic, raw, or customized product, make sure that we are delivering it at the right time, ensure that it is delivered in the specified amount, and in the right kind of packaging to clients and customers of all types of industries irrespective of their size of operation.
