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Sulfanilic acid 121-57-3

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CAS No.:

121-57-3

Grade:

Industrial Grade

Content:

99%

Port:

shanghai

Brand:

Orient

Packaging:

25kg/bag,500kg/bag, customized

Price valid (until):

2025-12-26

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Qingdao Orient Chemical Co.,LTD

Company Type:

Trader

Location:

China

Qualification:

Main Products:

pharmaceutical intermediates,peptides,electronic chemicals

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Product Description
Seller Information
Inquiry History

Description

Sulfanilic acid Basic information

Synthesize

Product Name:	Sulfanilic acid
Synonyms:	4-aminobenzenesulfonate;SULFANILIC ACID, ANHYDROUS, REAGENT (ACS)SULFANILIC ACID, ANHYDROUS, REAGENT (ACS)SULFANILIC ACID, ANHYDROUS, REAGENT (ACS)SULFANILIC ACID, ANHYDROUS, REAGENT (ACS);Diazobenzenesulfonic acid test solution(ChP);SULFANILIC ACID ANHYD PWD;Sulfanilic acid puriss. p.a., >=99.0% (T);Sulfanilic acid Vetec(TM) reagent grade, 99%;BES SODIUM SALT HIGH PURITY GRADE;p-Anilinesulfonic acid anhydrous
CAS:	121-57-3
MF:	C6H7NO3S
MW:	173.19
EINECS:	204-482-5
Product Categories:	Organics;INORGANIC & ORGANIC CHEMICALS;Intermediates of Dyes and Pigments;Amines;Aromatics;Sulfur & Selenium Compounds;bc0001
Mol File:	121-57-3.mol

Sulfanilic acid Chemical Properties

Melting point	>300 °C(lit.)
Boiling point	288 ℃
bulk density	620kg/m3
density	1.485
vapor pressure	0Pa at 25℃
refractive index	1.5500 (estimate)
storage temp.	Store below +30°C.
solubility	10g/l
pka	3.24(at 25℃)
form	solid
color	White to Off-White
PH	2.5 (10g/l, H2O, 20℃)
Water Solubility	0.1 g/100 mL (20 ºC)
Merck	14,8926
BRN	908765
Stability:	Stable. Incompatible with strong oxidizing agents.
InChIKey	HVBSAKJJOYLTQU-UHFFFAOYSA-N
LogP	-2.3 at 25℃
CAS DataBase Reference	121-57-3(CAS DataBase Reference)
NIST Chemistry Reference	Benzenesulfonic acid, 4-amino-(121-57-3)
EPA Substance Registry System	Sulfanilic acid (121-57-3)

Safety Information

Hazard Codes	C,Xi
Risk Statements	36/38-43-34
Safety Statements	26-36/37/39-45-37-24-36/37
RIDADR	UN 2790 8/PG 3
WGK Germany	1
RTECS	WP3895500
Autoignition Temperature	>400 °C
TSCA	Yes
HS Code	29214210
Hazardous Substances Data	121-57-3(Hazardous Substances Data)
Toxicity	LD50 orally in Rabbit: 12300 mg/kg

Sulfanilic acid Usage And Synthesis

Synthesize	Sulfanilic acid can be used for the determination of nitrite. Biochemical Research. Organic Synthesis. Sulfanilic acid is an important intermediate of sulfonamide drugs. This product has strong antibacterial effect on hemolytic streptococcus, meningitis and coccus, but due to poor efficacy and high toxicity, it is rarely used for oral administration. It is also rarely used. It is used as an intermediate for the synthesis of other sulfonamides, and is also used as a raw material for the synthesis of agricultural "Huangcaoling" abroad. Sulfanilic acid can also be used as an analytical reagent, such as a reagent for the photometric determination of nitrite and sodium nitroferricyanide. For biochemical research, organic synthesis and pharmaceutical industry. Sulfanilic acid is the main raw material for synthesizing sulfonamides. In addition to preparing crystalline sulfonamides for external anti-inflammatory, it can also synthesize other sulfonamides such as sulfamidine, sulfamethoxazine, and sulfamethazine.
Description	Sulfanilic acid (4-amino benzene sulfonic acid ) is an off-white crystalline solid which finds application in quantitative analysis of nitrate and nitrite ions. The solid acid exists as a zwitterion, and has an unusually high melting point.
Chemical Properties	greyish-white crystals or powder
Uses	A toxic metabolite of Tartrazine (T007700). Used as Ehrlich’s reagent, for detecting of nitrites. Antibacterial.
Uses	Sulfanilic Acid (Sulfadimethoxine EP Impurity D) is a toxic metabolite of Tartrazine (T007700). Used as Ehrlich’s reagent, for detecting of nitrites. Antibacterial.
Uses	Sulfanilic acid may be used for the functionalization of single-walled carbon nanotubes (SWNTs) with aryl sulfonate groups.
Definition	ChEBI: An aminobenzenesulfonic acid that is aniline sulfonated at the para-position.
Application	As the compound readily form diazo compounds, it is used to make dyes and sulpha drugs . This property is also used for the quantitative analysis of nitrate and nitrite ions by diazonium coupling reaction with N-(1-Naphthyl) ethylene diamine , resulting in an azo dye, and the concentration of nitrate or nitrite ions were deduced from the color intensity of the resulting red solution by colorimetry. It is also used as a standard in combustion analysis.
General Description	White powder with faint purple tinge. Grayish-white flat crystals. Becomes anhydrous at around 212°F. Low toxicity (used medicinally).
Air & Water Reactions	Insoluble in water.
Reactivity Profile	Sulfanilic acid is an amino acid. Reacts weakly with both acids and bases.
Fire Hazard	Flash point data for Sulfanilic acid are not available, however Sulfanilic acid is probably combustible.
Synthesis	Sulfanilic acid can be produced by sulfonation of aniline.
Purification Methods	Crystallise the acid (as dihydrate) from boiling water. Dry it at 105o for 2-3hours, then over 90% H2SO4 in a vacuum desiccator. The S-benzylisothiuronium salt has m 187o (from aqueous EtOH). [Beilstein 14 IV 2655.]

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—— Q&A ——

Q1:Do you provide sample?

A: Yes, we can provide free sample, you only need pay the shipping cost.

Q2: What is the lead time?

A: For stock goods, it usually take about 5-7 days by air, 15-30 days by sea,For customized products, the delivery time needs to be confirmed based on the actual situation.

Q3: How can I buy? What is the payment method?

A: You can contract us through Email or you can browse our website:orientchem.cc, we have bank transfer,

A：We attach great importance to after-sales service of our products. If there are any quality issues, please contact us within 30 days of receiving the goods and we will handle returns and exchanges for you.

Certificates

Basic Info

Product Name:

Sulfanilic acid

Other Name:

Benzenesulfonic acid,4-amino-;Sulfanilic acid;4-Aminobenzenesulfonic acid;p-Aminobenzenesulfonic acid;Aniline-p-sulfonic acid;Aniline-4-sulfonic acid;Sulphanilic acid;1-Aminobenzene-4-sulfonic acid;p-Aminophenylsulfonic acid;p-Sulfoaniline;4-Aminophenylsulfonic acid;4-Sulfoaniline;NSC 7170;856062-06-1

CAS No.:

121-57-3

Molecular Formula:

C6H7NO3S

InChIKeys:

InChIKey=HVBSAKJJOYLTQU-UHFFFAOYSA-N

Molecular Weight:

173.19

Exact Mass:

173.19

BRN:

908765

EC Number:

204-482-5

UNII:

434Z8C2635

ICSC Number:

0569

NSC Number:

7170

UN Number:

2585

DSSTox ID:

DTXSID6024464

Color/Form:

Orthorhombic plates or monoclinic from water

HScode:

29214210

Categories:

Bulk Drug Intermediates

Characteristics

PSA:

88.8

XLogP3:

-0.9

Appearance:

4-aminobenzene sulfonic acid appears as white powder with faint purple tinge. Grayish-white flat crystals. Becomes anhydrous at around 212°F. Low toxicity (used medicinally).

Density:

1.485 g/cm³ @ Temp: 25 °C

Melting Point:

288 °C

Boiling Point:

500ºC

Refractive Index:

1.5500 (estimate)

Water Solubility:

H2O: 0.1 g/100 mL (20 ºC)

Storage Conditions:

Store in dark!

Vapor Pressure:

1X10-9 mm Hg at 25 deg (est)

Toxicity:

Oral-Rat LD50: 12300 mg/kg

Flammability characteristics:

Combustion produces toxic nitrogen oxide and sulfur oxide gas

Henrys Law Constant:

Henry's Law constant = 8.9X10-13 atm-cu m/mole at 25 °C (est)

Dissociation Constants:

pKa = 3.25 at 25 °C; pKa = 3.34 at 15 °C

Experimental Properties:

Orthorhombic plates from water; decomposes without melting at about 288 °C (Also reported as greater than 360 °C); almost insoluble in ethanol, ether, benzene; slightly soluble in hot methanol; K2 at 25 °C: 5.93x10-4 /Sulfanilic acid monohydrate/|Grayish white, flat crystals /Sulfanilic acid monohydrate/|Hydroxyl radical reaction rate constant = 2.3X10-11 cu cm/molecule-sec at 25 °C (est)

Air and Water Reactions:

Insoluble in water.

Reactive Group:

Amines, Phosphines, and Pyridines

Reactivity Profile:

4-AMINOBENZENE SULFONIC ACID is an amino acid. Reacts weakly with both acids and bases.

See More Sulfanilic acid Properties 

Hazard Identification

Classification of the substance or mixture

Skin irritation, Category 2

Eye irritation, Category 2

Skin sensitization, Category 1

GHS label elements, including precautionary statements

Precautionary statement(s)
Pictogram(s)
Signal word	Warning
Hazard statement(s)	H315 Causes skin irritation H319 Causes serious eye irritation H317 May cause an allergic skin reaction
Prevention	P264 Wash ... thoroughly after handling. P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/... P261 Avoid breathing dust/fume/gas/mist/vapours/spray. P272 Contaminated work clothing should not be allowed out of the workplace.
Response	P302+P352 IF ON SKIN: Wash with plenty of water/... P321 Specific treatment (see ... on this label). P332+P317 If skin irritation occurs: Get medical help. P362+P364 Take off contaminated clothing and wash it before reuse. P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P333+P317 If skin irritation or rash occurs: Get medical help.
Storage	none
Disposal	P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.

Other hazards which do not result in classification

no data available

Handling and Storage

Precautions for safe handling

NO open flames. Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Conditions for safe storage, including any incompatibilities

Separated from strong acids and strong bases.

See More Sulfanilic acid Safety Data Sheet 

Seller Information

Business Type:
Trader

Main Products:
pharmaceutical intermediates,peptides,electronic chemicals

Location:
Room 102, 1st Floor, East Office Building, No. 45 Pengwan Road, Qianwan Bonded Port Area, Qingdao Zone, China (Shandong) Pilot Free Trade Zone

Payment Terms:
100% TT in advance

Average lead Time:
10

Total Annual Revenue:
$10 million-$25 million

Total Employees:
51-100

Year of Establishment:
2024

A reliable supplier is like insurance.

We are mainly specilized in supply of pharmaceutical intermediates, electronic chemicals，food additives, and other fine chemical products.
Integrity is the foundation, quality is life. We would like to work together with you to build a greener and brighter future.

Website: orientchem.cc
Email: scarlett@orientchem.cc
WhatsApp: +86 17753254221

Inquiry History

11 Inquiries

Country	Product	Purchase Quantity	Date Posted
India	Sulfanilic acid	1.00 MT	Jul 13, 2023
India	Sulfanilic acid	1.00 MT	Jul 12, 2023
India	Sulfanilic acid	20.00 MT	Sep 15, 2023
India	Sulfanilic acid	20.00 MT	Oct 26, 2023
India	Sulfanilic acid	2.00 20' Fcl	Jul 12, 2023
Pakistan	Sulphanilic acid	1000 KG	Nov 18, 2025
India	Sulphanilic Acid	25 KG	Jul 1, 2026
India	Sulfo J Acid	1.00 MT	Jul 13, 2023
India	Sulfo J Acid	1.00 MT	Jul 12, 2023
India	Dimethyl acetylsuccinate	2.00 20' Fcl	Jul 12, 2023
India	acid/3-Amino-8-Naphthol-6-Sulfonic acid	1.00 20' Fcl	Jul 12, 2023

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