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BEST MAROPITANT maropitant buy - large image1
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BEST MAROPITANT maropitant

Unit Price: Get Latest Price
CAS No.:

147116-67-4

Content:

99%

Port:

Any Chinese seaport or airport

Brand:

JIU LONG

Packaging:

25kg/drum

Price valid (until):

2025-12-28

Company Type:
Manufactory
Location:
China
Qualification:
Main Products:

Tildipirosin,Tilmicosin Phosphate,Tilmicosin

  • Product Description

  • Seller Information

  • Description


      Product Detail  


    Product Name: Maropitant
    CAS number: 147116-67-4
    Molecular formula: C32H40N2O
    Molecular weight: 468.67
    Appearance: off white to yellow granules or powder
    Density: 1.11 ± 0.1 g/cm3
    Boiling point: 572.6 ± 50.0 ° C
    Acidity coefficient: 9.99 ± 0.70
    Solubility: DMSO: 33.33 mg/mL (71.12 mM; ultrasound required)
    H2O:<0.1 mg/mL (insoluble)
    Storage: Store in a dark, dry, sealed, and cool place


    Maropitant is a neurokinin (NK1) receptor antagonist that can block the binding of substance P to receptors in the central nervous system and has antiemetic effects. Substance P is a type of neurotransmitter associated with vomiting. Blocking the binding between substance P and its receptors can effectively inhibit central nervous system vomiting, peripheral nervous system vomiting, and vomiting caused by chemical factors.
    Indications: Used for the prevention and treatment of vomiting caused by chemotherapy drugs in dogs and cats, as well as vomiting other than motion sickness.
    Preparation specification: Calculated based on Malopitant.
    Maropitant citrate tablets: 16mg/tablet, 24mg/tablet, 60mg/tablet, 160mg/tablet.
    Malapitant Citrate Injection: 20ml: 0.2g.


    Pharmacokinetics: The bioavailability of Malopitant is not affected by feeding, with a single oral dose of 2mg/kg and a bioavailability of 23.7%. The binding rate to plasma proteins is higher than 99%. The peak plasma concentration (Cmax) is about 81ng/ml, the peak time (Tmax) is about 1.9 hours, and the half-life (t1/2) is 4.03 hours. There are significant differences in pharmacokinetics among individual animals, with the highest variable (CV) of the drug time curve (AUC) being 70%. In clinical trials, it has been shown that the medication begins to exert its effects one hour after taking and can last for 24 hours.
    Metabolism: Malopitant is mainly metabolized through the liver, and the hepatic enzymes that metabolize Malopitant in dogs are CYP2D15 and CYP3A12. The clearance rate of Maropitant and its metabolites through the kidneys is less than 1%.


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    Items Specifications
    Max single impurity≤0.2%
    0.05
    Total impurities ≤0.5%
    0.4
    Assay 98.5%

    Basic Info
    Product Name:

    Maropitant

    Other Name:

    1-Azabicyclo[2.2.2]octan-3-amine,N-[[5-(1,1-dimethylethyl)-2-methoxyphenyl]methyl]-2-(diphenylmethyl)-,(2S,3S)-;1-Azabicyclo[2.2.2]octan-3-amine,N-[[5-(1,1-dimethylethyl)-2-methoxyphenyl]methyl]-2-(diphenylmethyl)-,(2S-cis)-;(2S,3S)-N-[[5-(1,1-Dimethylethyl)-2-methoxyphenyl]methyl]-2-(diphenylmethyl)-1-azabicyclo[2.2.2]octan-3-amine;Maropitant;(2S,3S)-2-Benzhydryl-N-(5-tert-butyl-2-methoxybenzyl)quinuclidin-3-amine;Prevomax

    CAS No.:

    147116-67-4

    Molecular Formula:

    C32H40N2O

    InChIKeys:

    InChIKey=OMPCVMLFFSQFIX-CONSDPRKSA-N

    Molecular Weight:

    468.7

    Exact Mass:

    468.67

    EC Number:

    831-973-7

    UNII:

    4XE2T9H4DH

    ATC Code:

    QA04AD90

    Characteristics

    Hazard Identification

    Classification of the substance or mixture

    Skin sensitization, Category 1

    Specific target organ toxicity – repeated exposure, Category 2

    Hazardous to the aquatic environment, short-term (Acute) - Category Acute 1

    Hazardous to the aquatic environment, long-term (Chronic) - Category Chronic 1

    GHS label elements, including precautionary statements

    Pictogram(s)
    Signal word

    Warning

    Hazard statement(s)

    H317 May cause an allergic skin reaction

    H373 May cause damage to organs through prolonged or repeated exposure

    H410 Very toxic to aquatic life with long lasting effects

    Precautionary statement(s)
    Prevention

    P261 Avoid breathing dust/fume/gas/mist/vapours/spray.

    P272 Contaminated work clothing should not be allowed out of the workplace.

    P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/...

    P260 Do not breathe dust/fume/gas/mist/vapours/spray.

    P273 Avoid release to the environment.

    Response

    P302+P352 IF ON SKIN: Wash with plenty of water/...

    P333+P317 If skin irritation or rash occurs: Get medical help.

    P321 Specific treatment (see ... on this label).

    P362+P364 Take off contaminated clothing and wash it before reuse.

    P319 Get medical help if you feel unwell.

    P391 Collect spillage.

    Storage

    none

    Disposal

    P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.

    Other hazards which do not result in classification

    no data available

    Handling and Storage

    Precautions for safe handling

    Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

    Conditions for safe storage, including any incompatibilities

    Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.

  • Seller Information
    Business Type:

    Manufactory

    Main Products:

    Tildipirosin,Tilmicosin Phosphate,Tilmicosin

    Location:

    Yinfeng International Biopark, No.1177 Chunlan Road, High-tech district, Jinan City, Shandong Province

    Payment Terms:

    TT against copy of documents,D/P,L/C,D/A,O/A,TT against B/L draft before shipment,100% TT in advance

    Average lead Time:

    365

    Total Annual Revenue:

    $2.5 million-$5 million

    Total Employees:

    101-200

    Year of Establishment:

    2008

    Certifications:

    GMP

    Company Profile
  • Country Product Purchase Quantity Date Posted
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