Fmoc-Gly-OH CAS:29022-11-5

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Fmoc-Gly-OH Basic information

Product Name:	Fmoc-Gly-OH
Synonyms:	9-FLUORENYLMETHOXYCARBONYL-GLYCINE;FMOC-L-GLY-OH;FMOC-L-GLY;FMOC-L-GLYCINE;FMOC-GLYCINE;FMOC-GLY;FMOC-GLY-OH;F-FMOC-GLYCINE
CAS:	29022-11-5
MF:	C17H15NO4
MW:	297.31
EINECS:	249-373-3
Product Categories:	Glycine [Gly, G];Fmoc-Amino Acids and Derivatives;Amino Acids (N-Protected);Biochemistry;Fmoc-Amino Acids;Fmoc-Amino acid series;Protected Amino Acids;Fluorenes, Flurenones;AMINOACIDS DERIVATIVES;Amino Acid Derivatives;Amino Acids;Azepanes/Diazepanes
Mol File:	29022-11-5.mol

Fmoc-Gly-OH Chemical Properties

Melting point	174-175 °C(lit.)
Boiling point	438.82°C (rough estimate)
density	1.1671 (rough estimate)
refractive index	1.4500 (estimate)
storage temp.	2-8°C
solubility	almost transparency in Methanol
form	Powder
pka	3.89±0.10(Predicted)
color	White
BRN	2163967
InChI	InChI=1S/C17H15NO4/c19-16(20)9-18-17(21)22-10-15-13-7-3-1-5-11(13)12-6-2-4-8-14(12)15/h1-8,15H,9-10H2,(H,18,21)(H,19,20)
InChIKey	NDKDFTQNXLHCGO-UHFFFAOYSA-N
SMILES	C(O)(=O)CNC(OCC1C2=C(C=CC=C2)C2=C1C=CC=C2)=O
CAS DataBase Reference	29022-11-5(CAS DataBase Reference)

Safety Information

Hazard Codes	Xi
Risk Statements	36/37/38
Safety Statements	24/25-36-26
WGK Germany	3
HS Code	29242995

MSDS Information

Fmoc-Gly-OH Usage And Synthesis

Chemical Properties	white to light yellow crystal powde
Uses	Fmoc-Gly-OH is an N-Fmoc-protected form of Glycine (G615990). Glycine is a nonessential amino acid that acts as an inhibitory neyrotransmitter in the vertebrate central nervous system. Glycine also posesses cytoprotective against oxidant damage in the kidney.
Preparation	Glycine (Gly) (0.5 g, 6.66 mmol) was dissolved in 10% NaCO3 (14 ml) under stirring in a 50-ml flask. To the resulting solution, which had been put into an ice bath, 9-fluorenylmethoxycarbonyl chloride (Fmoc-Cl) (1.72 g, 6.66 mmol) in dioxane (12 ml) was gradually added. The reaction mixture was stirred at room temperature for 4 hours. Then added water (150 ml) to the mixture. The aqueous phase layer was separated from the reaction mixture and stripped with ether three times (75 ml×3). The stripped aqueous layer was acidified with 2N HCl aqueous solution to a pH=2, followed by extraction with ethyl acetate three times (75 ml×3). The organic phase layer was recovered and concentrated to obtain crude product of 1.70 g. The crude product was recrystallized in a mixed solvent of ethyl acetate hexane=1:2 (30 ml), and white solid denoted as Fmoc-Gly-OH was obtained after filtration at a reduced pressure.
General Description	Fmoc-Gly-OH is used for fmoc solid-phase peptide synthesis.
reaction suitability	reaction type: Fmoc solid-phase peptide synthesis

Fmoc-Gly-OH Preparation Products And Raw materials

Preparation Products

Piperidine, 1-(9H-fluoren-9-ylmethyl)--->FMOC-ALA-GLY-OH-->FMOC-GLY-OSU-->FMOC-GLY-OPFP-->MELITTIN-->5-Bromo-7-nitroindoline-->FMOC-SARCOSINE MONOHYDRATE-->N-Fmoc-(1-benzotriazolylcarbonyl)methylamine-->Copper Peptide-->Fmoc-Gly-DL-Ala-->H-HIS-GLY-GLY-OH-->methyl 2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)acetate-->Fmoc-Gly-ODhbt

First aid measures	General advice Consult a physician. Show this material safety data sheet to the doctor in attendance. If inhaled If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician. In case of skin contact Wash off with soap and plenty of water. Consult a physician. In case of eye contact Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician. If swallowed Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.
Firefighting measures	Suitable extinguishing media Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide. Special hazards arising from the substance or mixture Carbon oxides Nitrogen oxides (NOx) Advice for firefighters Wear self-contained breathing apparatus for firefighting if necessary.
Accidental release measures	Personal precautions, protective equipment and emergency procedures Use personal protective equipment. Avoid dust formation. Avoid breathing vapors, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8. Environmental precautions Do not let product enter drains. Methods and materials for containment and cleaning up Pick up and arrange disposal without creating dust. Sweep up and shovel. Keep in suitable, closed containers for disposal.



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