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ALPHA-LINOLENIC ACID CAS:463-40-1

Name: ALPHA-LINOLENIC ACID CAS:463-40-1
Brand: Orient
SKU: pr2512241090
Price: 4 USD
Availability: InStock

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CAS No.:

463-40-1

Grade:

Industrail Grade

Content:

99%

Port:

SHANGHAI

Brand:

Orient

Packaging:

25L, 200L, 1000L, customized

Price valid (until):

2026-01-24

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Qingdao Orient Chemical Co.,LTD

Company Type:

Trader

Location:

China

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Main Products:

pharmaceutical intermediates,peptides,electronic chemicals

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Product Description
Seller Information
Inquiry History

Description

Product Name:	Linolenic acid
Synonyms:	OCTADECA-9Z,12Z,15Z-TRIENOIC ACID;(Z,Z,Z)-9,12,15-Octadecatrienoic acid;9,12,15-OCTADECATRIENIC ACID;9,12,15-OCTADECATRIENOIC ACID;9Z,12Z,15Z-OCTADECATRIENOIC ACID;ALPHA-LINOLENIC ACID;ALPHA-LNN;ALL CIS-9,12,15-OCTADECATRIENOIC ACID
CAS:	463-40-1
MF:	C18H30O2
MW:	278.43
EINECS:	207-334-8
Product Categories:	Biochemistry;Higher Fatty Acids & Higher Alcohols;Fatty & Aliphatic Acids, Esters, Alcohols & Derivatives;Unsaturated Higher Fatty Acids;Fatty Acid Derivatives & Lipids;Glycerols;Biological and chemical;Elisa Kit-plant ELISA Kit;1
Mol File:	463-40-1.mol

Linolenic acid Chemical Properties

Melting point	-11 °C(lit.)
Boiling point	230-232 °C1 mm Hg(lit.)
density	0.914 g/mL at 25 °C(lit.)
FEMA	3380 \| 9,12-OCTADECADIENOIC ACID (48%) AND 9,12,15-OCTADECATRIENOIC ACID (52%)
refractive index	n20/D 1.480(lit.)
Fp	>230 °F
storage temp.	2-8°C
solubility	Chloroform, Ethyl Acetate (Slightly), Methanol (Slightly)
pka	4.78±0.10(Predicted)
form	Liquid
color	Clear colorless to light yellow
Specific Gravity	0.91
Odor	faint fatty
Water Solubility	INSOLUBLE
Merck	14,5506
BRN	1727693
Cosmetics Ingredients Functions	ANTISTATIC SURFACTANT - CLEANSING PERFUMING CLEANSING HAIR CONDITIONING SKIN CONDITIONING SKIN CONDITIONING - EMOLLIENT
InChIKey	DTOSIQBPPRVQHS-PDBXOOCHSA-N
LogP	6.52
CAS DataBase Reference	463-40-1(CAS DataBase Reference)
NIST Chemistry Reference	9,12,15-Octadecatrienoic acid, (Z,Z,Z)-(463-40-1)
EPA Substance Registry System	Linolenic acid (463-40-1)

Safety Information

Risk Statements	36/37/38
Safety Statements	26-36-37/39
RIDADR	UN1170 - class 3 - PG 2 - Ethanol
WGK Germany	1
F	8-10-23
HS Code	29161500

MSDS Information

Linolenic acid Usage And Synthesis

Overview

The alpha-linolenic acid (ALA 18:3w,463-40-1) an omega-3 (n-3) fatty acid, is an essential fatty acid (EFA) that cannot be synthesized by the body and therefore must be supplied by dietary sources. ALA is abundant in certain plant foods including walnuts, rapeseed (canola), several legumes, flaxseed, and green leafy vegetables.^[1] ALA is the precursor of three important longer-chain n-3 fatty acids, eicosapentaenoic acid (EPA 20:5w3), docosapentaenoic acid (DPAw3 22:5w3), and docosahexaenoic acid (DHA 22:6w3), which have vital roles in brain development and function, cardiovascular health, and inflammatory response.^[2-5] Omega-3 fatty acids are incorporated into the membrane lipid bilayer in virtually all body cells and affect membrane composition, eicosanoid biosynthesis, cell signaling cascades, and gene expression^[6].

Absorption and metabolism of ALA

As a rule, dietary fats are absorbed very efficiently from the digestive tract, and ALA is no exception. Burdge 16 recently reported that absorption levels of ALA are 96% or more. There are several possible metabolic fates for ALA that enters the bloodstream. The body can store the fatty acids in adipose tissue, use them for acetyl-CoA or energy production through b-oxidation, synthesize other non-essential saturated or monounsaturated fatty acids (MUFA), or convert them to longer-chain n-3 polyunsaturated fatty acids (PUFA) in the liver. The activity of the desaturation/elongation pathway is of unique importance as it is responsible for the synthesis of EPA and DHA. What is presently understood concerning conversion of ALA to EPA, DPAw3, and DHA is that the first step in the pathway, addition of a fourth double bond by D 6 desaturase, is considered to be the rate-limiting step. This is followed by elongation (addition of two carbon atoms) and an additional desaturation by the enzyme D 5 desaturase, with the product being 20:5n-3 or EPA. Several possibilities have been suggested for the precise pathway for production of DHA (22:6n-3) from EPA in humans. It was assumed that the conversion of DPAw3 to DHA would be carried out by a D4 desaturase but, thus far, little or no D4 desaturase has been found. Sprecher^[8] has provided evidence for elongation of 22:5w3 to 24:5w3,which is then desaturated by the rate limiting D 6 desaturase to yield a 24:6w3. Two carbons are then cleaved in the peroxisomes to yield DHA that is then exported to the reticuloendothelial system. Thus, the insertion of the last double bond in DHA production in human metabolism may be rather indirect and somewhat inefficient. There are some doubts as to the validity of the Sprecher shunt, but it provides a possible explanation for the small proportions of DHA produced and the build up of DPAw3, despite ample ALA available in foods and in body tissues.
Alpha-linolenic acid is partially converted to EPA in humans (8–20%), while conversion rates of ALA to DHA are estimated at 0.5–9%^{[9, 10]}. The sex difference in metabolism is well known. Studies in women of reproductive age showed a substantially greater (2.5-fold) rate of conversion of ALA to EPA than that measured in healthy men. Thus, the ability to produce long-chain metabolites is gender dependent. It appears that women have a lower partitioning of ALA to b-oxidation, leaving more of it available for conversion to EPA^{[7, 11]}. Other possible explanations include a direct effect of estrogen on conversion rates^{[7, 12]}. Gender differences have also been observed in the conversion rates of ALA to DHA. In males it is estimated that only 0.5–4% of ALA is converted to DHA while in females the rates are thought to be as high as 9%^{[11, 12]}. It is hypothesized that demands for DHA by the fetus during pregnancy may stimulate female physiology to more readily synthesize this fatty acid.

First aid measures

If inhaled

Move the victim into fresh air. If breathing is difficult, give oxygen. If not breathing, give artificial respiration and consult a doctor immediately. Do not use mouth to mouth resuscitation if the victim ingested or inhaled the chemical.

Following skin contact

Take off contaminated clothing immediately. Wash off with soap and plenty of water. Consult a doctor.

Following eye contact

Rinse with pure water for at least 15 minutes. Consult a doctor.

Following ingestion

Rinse mouth with water. Do not induce vomiting. Never give anything by mouth to an unconscious person. Call a doctor or Poison Control Center immediately.

Accidental release measures

Personal precautions, protective equipment and emergency procedures

Avoid dust formation. Avoid breathing mist, gas or vapours.Avoid contacting with skin and eye. Use personal protective equipment.Wear chemical impermeable gloves. Ensure adequate ventilation.Remove all sources of ignition. Evacuate personnel to safe areas.Keep people away from and upwind of spill/leak. Environmental precautions

Prevent further spillage or leakage if it is safe to do so. Do not let the chemical enter drains. Discharge into the environment must be avoided. Methods and materials for containment and cleaning up

Collect and arrange disposal. Keep the chemical in suitable and closed containers for disposal. Remove all sources of ignition. Use spark-proof tools and explosion-proof equipment. Adhered or collected material should be promptly disposed of, in accordance with appropriate laws and regulations.

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—— Q&A ——

Q1:Do you provide sample?

A: Yes, we can provide free sample, you only need pay the shipping cost.

Q2: What is the lead time?

A: For stock goods, it usually take about 5-7 days by air, 15-30 days by sea,For customized products, the delivery time needs to be confirmed based on the actual situation.

Q3: How can I buy? What is the payment method?

A: You can contract us through Email or you can browse our website:orientchem.cc, we have bank transfer,

Q4:What if there are quality issues？

A：We attach great importance to after-sales service of our products. If there are any quality issues, please contact us within 30 days of receiving the goods and we will handle returns and exchanges for you.

Certificates

Basic Info

Product Name:

Linolenic acid

Other Name:

9,12,15-Octadecatrienoic acid,(9Z,12Z,15Z)-;Linolenic acid;9,12,15-Octadecatrienoic acid,(Z,Z,Z)-;(9Z,12Z,15Z)-9,12,15-Octadecatrienoic acid;all-cis-9,12,15-Octadecatrienoic acid;α-Linolenic acid;cis,cis,cis-9,12,15-Octadecatrienoic acid;cis-9,cis-12,cis-15-Octadecatrienoic acid;cis-Δ9,12,15-Octadecatrienoic acid;9,12,15-all-cis-Octadecatrienoic acid;9-cis,12-cis,15-cis-Octadecatrienoic acid;(Z,Z,Z)-Octadeca-9,12,15-trienoic acid;(all-Z)-9,12,15-Octadecatrienoic acid;9Z,12Z,15Z-Octadecatrienoic acid;alpha-Linolenic acid;18:3n-3;BRD-K33396764

CAS No.:

463-40-1

Molecular Formula:

C18H30O2

InChIKeys:

InChIKey=DTOSIQBPPRVQHS-PDBXOOCHSA-N

Molecular Weight:

278.43

Exact Mass:

278.43

EC Number:

207-334-8

UNII:

0RBV727H71

NSC Number:

2042

DSSTox ID:

DTXSID7025506|DTXSID9029435|DTXSID7075058

NCI Thesaurus Code:

C997

HScode:

2916190090

Categories:

Bulk Drug Intermediates

Characteristics

PSA:

37.3

XLogP3:

5.9

Appearance:

Clear colorless to light yellow Liquid

Density:

0.9157 g/cm³ @ Temp: 20 °C

Melting Point:

-16.5 °C

Boiling Point:

231 °C

Flash Point:

>230 °F

Refractive Index:

1.491

Water Solubility:

H2O: INsoluble

Storage Conditions:

2-8°C

Vapor Pressure:

0.05 mm Hg at 257° F (NTP, 1992)

Collision Cross Section:

170.7 Å² [M+H]+ [CCS Type: DT, Method: single field calibrated with Agilent tune mix (Agilent)]|173.07 Å² [M-H]- [CCS Type: DT, Method: single field calibrated with Agilent tune mix (Agilent)]|174.88 Å² [M-H]- [CCS Type: DT, Method: stepped-field]|173.9 Å² [M-H]-

Air and Water Reactions:

Oxidizes in air to form peroxides, which spontaneously ignite. Insoluble in water. Sensitive to heat and moisture.

Reactive Group:

Acids, Carboxylic

Reactivity Alerts:

Peroxidizable Compound

Reactivity Profile:

LINOLENIC ACID is incompatible with bases, oxidizing agents and reducing agents. Also incompatible with peroxides, oxygen and water. (NTP, 1992)

See More Linolenic acid Properties 

Hazard Identification

Classification of the substance or mixture

Not classified.

GHS label elements, including precautionary statements

Precautionary statement(s)
Pictogram(s)	No symbol.
Signal word	No signal word
Hazard statement(s)	none
Prevention	none
Response	none
Storage	none
Disposal	none

Other hazards which do not result in classification

no data available

Handling and Storage

Precautions for safe handling

Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Conditions for safe storage, including any incompatibilities

Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.

See More Linolenic acid Safety Data Sheet 

Seller Information

Business Type:
Trader

Main Products:
pharmaceutical intermediates,peptides,electronic chemicals

Location:
Room 102, 1st Floor, East Office Building, No. 45 Pengwan Road, Qianwan Bonded Port Area, Qingdao Zone, China (Shandong) Pilot Free Trade Zone

Payment Terms:
100% TT in advance

Average lead Time:
10

Total Annual Revenue:
$10 million-$25 million

Total Employees:
51-100

Year of Establishment:
2024

A reliable supplier is like insurance.

We are mainly specilized in supply of pharmaceutical intermediates, electronic chemicals，food additives, and other fine chemical products.
Integrity is the foundation, quality is life. We would like to work together with you to build a greener and brighter future.

Website: orientchem.cc
Email: scarlett@orientchem.cc
WhatsApp: +86 17753254221

Inquiry History

3 Inquiries

Country	Product	Purchase Quantity	Date Posted
India	Linolenic Acid	50 G	Oct 24, 2025
Romania	oliar fertilizer liquid nanotechnology fertilizers	20000 MT	Aug 31, 2023
United Arab Emirates	Apha Linoleic Acid	25 MT	Dec 23, 2025

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