Hot Sales Beauty Peptide ACTH 1-39 Peptide 98% ready stock ship safe

ACTH (1-39) is a synthetic 39-amino acid peptide representing the full-length endogenous adrenocorticotropic hormone. It binds melanocortin receptors (MCRs) to regulate adrenal steroidogenesis and modulate stress responses. This research-grade compound enables studies on hypothalamic-pituitary-adrenal (HPA) axis dynamics, immune modulation, and metabolic pathways.                         

Mechanism of Action

Binds melanocortin 2 receptor (MC2R) on adrenal cortex cells, activating adenylate cyclase → ↑cAMP → ↑steroidogenic acute regulatory (StAR) protein → cortisol synthesis. Cross-reactivity with MC1R/MC3R contributes to extra-adrenal effects.

Experimental Notes

• Reconstitution: Dissolve in 0.1M acetic acid to prevent aggregation; aliquot to avoid freeze-thaw cycles.

• Bioactivity Validation:

  • In vitro: Stimulates ≥2-fold corticosterone increase in Y1 mouse adrenal cells (EC₅₀: 0.1-1 nM).

  • In vivo: 10 μg/kg IV in rats elevates plasma corticosterone within 15 min.

  • Safety & Compliance

    • Research Use Only: Not for diagnostic, therapeutic, human, or veterinary applications.

    • Handling: Use PPE (gloves, lab coat); avoid inhalation. Refer to SDS for protocols.

Key Research Applications

1. HPA Axis Studies:

   • Stimulates cortisol/corticosterone release in adrenal cell models for investigating stress physiology and glucocorticoid feedback mechanisms.

2. Metabolic Regulation:

   • Modulates glucose metabolism and lipolysis via cAMP/PKA signaling in adipose tissue.

3. Immunomodulation:

   • Suppresses pro-inflammatory cytokines (e.g., TNF-α, IL-6) through MC2R activation in macrophages.

4. Behavioral Research:

   • Evaluates stress-induced behavioral changes (e.g., anxiety, cognition) in rodent models.

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1. Ultra-High Purity
Each batch is synthesized and purified to >99% purity (HPLC), ensuring reliable and reproducible results in sensitive experiments.

2.Accurate Dosing & Consistency
Our peptides are precisely weighed and vacuum-sealed under sterile conditions. Batch-to-batch consistency is rigorously maintained.

3.Endotoxin-Free & Sterile Processing
Manufactured in a cleanroom environment, our peptides are free from endotoxins, microbial contamination, and other impurities that could interfere with cell-based or in vivo studies.